The effect of new reducing agent on discoloration by silver diamine fluoride

2021 Fiscal Year Final Research Report

• Project/Area Number: 17K17124
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Conservative dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Matsui Naoko 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (10754963)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Keywords: フッ化ジアンミン銀

Outline of Final Research Achievements

In order to deal with root caries in a super-aging society, we pursued the possibility of clinical application of a new reducing agent in combination with silver diamine fluoride (SDF) to tooth surface. A new reducing agent (glutathione) or potassium iodide was mixed with SDF, and the discoloration suppressing effect, antibacterial property, demineralization suppressing effect and biofilm adhesion were verified.
For the results, the discoloration due to SDF changes depending on the concentration, and the method of using a reducing agent in combination with SDF application to suppress discoloration has the effect of suppressing discoloration, but the effect of suppressing decalcification and the effect of suppressing biofilm adhesion. Was suggested to be inferior to conventional SDF application alone.

Free Research Field

歯科保存修復

Academic Significance and Societal Importance of the Research Achievements

近年の超高齢社会を迎えた我が国は中・高年者の保有歯数の増加に伴い、露出根面に発生する“根面う蝕”の急増が問題となっている。高齢者・要介護者の根面う蝕の１次予防処置としてフッ化ジアンミン銀（以下SDFと記載）の歯根面への塗布の有効性が高く評価されている。本研究はSDF塗布による黒変という欠点を改善し、SDFのより幅広い応用と高齢者・要介護者のQOL向上に大いに貢献するものと考えられる。