Development of presymptomatic diagnosis for anti-resorptive agents-related osteonecrosis of the jaw (ARONJ)

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K17181
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Hiroshima University (2018-2019); Kyushu University (2017)
• Principal Investigator: Mine Yuichi 広島大学, 医系科学研究科(歯), 講師 (60605989)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: ARONJ / 発症前診断 / 新規マウスモデル

Outline of Final Research Achievements

Anti-resorptive agents-related osteonecrosis of the jaw (ARONJ) is a rare but potentially severe adverse effect in patients medicating anti-resorptive drugs. In 2017, the Japanese Allied Committee on Osteonecrosis of the Jaw proposed several risk factors related to local, antiresorptive agents, systemic, congenital, lifestyle and co-administered agents. Whereas this position paper mentioned that these risk factors are including hypothesis without robust medical evidence. In fact, the mechanism of occurrence responsible for ARONJ is still not fully understood. Here, we establish the novel experimental ARONJ model mice, and investigate the potential of biomarkers as presymptomatic diagnosis.

Free Research Field

骨生物学

Academic Significance and Societal Importance of the Research Achievements

骨吸収薬関連顎骨壊死（ARONJ）は、補綴歯科治療に深く関係するインプラント埋入、不適合義歯や過大な咬合力等もリスク因子として考えられている。一方、骨吸収抑制薬は臨床的に有効性の高い薬剤であり、ARONJ発生のリスクと骨折予防のベネフィット等を正確に理解し、歯科治療を実施する必要がある。本研究では、より安全な骨吸収抑制薬の使用と補綴歯科治療に貢献する基礎的な知見を得ることができたと考える。