Development of new prevention and treatment methods for Medication-Related Osteo Necrosis of the Jaw

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K17182
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Kyushu University
• Principal Investigator: YASUNAMI NORIYUKI 九州大学, 歯学研究院, 助教 (00758021)
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: MRONJ

Outline of Final Research Achievements

Medication-Related Osteo Necrosis of the Jaw (MRONJ) marked by necrosis of bone is a big problem in dental field. However, the causes have not solved yet and there is no treatment for it. The aim of the present study was to search for new treatment and prevention methods of MRONJ. The Zoledronic acid and Dexamethasone was injected into the percutaneous administration of rat. After the maxillary right first molar of rat was extracted, we confirmed bone exposure and sequestration at the extraction socket. We are going to research about new treatment and prevention methods for MRONJ with it.

Free Research Field

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Academic Significance and Societal Importance of the Research Achievements

近年、骨吸収抑制薬や抗RANKL抗体による副作用として顎骨壊死や骨髄炎に似た骨露出が報告されるようになってきた。この薬剤関連顎骨壊死(MRONJ)において確立した予防・治療法がないのが現状である。本実験において、MRONJ様ラットを作製できることを確認した。すなわち、このモデルを用いることによって難治性であるMRONJに対する新規予防・治療法を模索することが可能である。今後はこのMRONJ様ラットを用いてMRONJに対する新規予防・治療法を模索していく予定である。