Development of new DDS applied freeze-dried platelet-rich plasma to MRONJ

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K17270
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Nagasaki University
• Principal Investigator: KOGA Takamitsu 長崎大学, 病院(歯学系), 助教 (50779428)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 多血小板血漿

Outline of Final Research Achievements

FD-PRP controlled release gelatine hydrogel sheet was created and performed to transplant to rat back skin wound model. Promotion of the epithelization was observed in a part of FD-PRP transplant group, however there was no statistical significant difference in comparison with control group. Also we tried to create the rat MRONJ onset model. However the onset of MRONJ was not able to confirm in all individuals, it was not achieved that FD-PRP controlled release gelatine hydrogel sheet applied to MRONJ onset model.
We obtained some findings about efficacy of FD-PRP controlled release gelatine hydrogel sheet for wound healing, the density of FD-PRP was examined in detail.

Free Research Field

口腔外科

Academic Significance and Societal Importance of the Research Achievements

本研究ではFD-PRP徐放性ゼラチンハイドロゲルシートをMRONJ治療薬として応用することを試みたが、現段階では疾患モデルへの移植を行うに至っておらず、有効性が確認できていない。ただし、FD-PRP 徐放性ゼラチンハイドロゲルシートの作製技術の確立と、一部軟組織再生への有効性が示されたことから、難治性口腔粘膜疾患への応用が可能ではないかと考えられる。