Study of novel CAF led-type cancer invasion triggered by cancer death vesicles

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K17612
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology; Cell biology
• Research Institution: Akita University
• Principal Investigator: Itoh Go 秋田大学, 医学系研究科, 助教 (60607563)
• Research Collaborator: Tanaka Masamitsu ; Goto Akiteru ; Yashiro Masakazu
• Project Period (FY): 2017-04-01 – 2019-03-31
• Keywords: 癌関連線維芽細胞 / 癌微小環境 / 癌浸潤モード / 癌ジオメトリー

Outline of Final Research Achievements

There are different modes of invasion in the process of cancer spread. One is expansive invasion, in which a group of cancer cells gradually expands along with cancer cell proliferation. The other is a more extensive invasion promoted by interactions with stromal cells, including cancer associated fibroblasts (CAF). In the present study, it was shown that CAF induces a certain number of apoptosis in gastric cancer cells, which prevents the cancer-expansive invasion, and instead promotes CAF-led widespread invasion.

Free Research Field

腫瘍生物学

Academic Significance and Societal Importance of the Research Achievements

圧排性増殖型の浸潤癌は癌患部の切除によって根治可能である。一方、播種型浸潤の癌における予後は良くない。これらの浸潤型の選択メカニズムは不明であった。本研究では、世界に先駆けてこのメカニズムに注目し、その成果を論文報告した。今後、播種性浸潤の抑制に繋がる研究を進め、癌治療へ繋げることを目指している。