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2020 Fiscal Year Annual Research Report

Clinical relevance of dietary flavonoid-drug interactions.

Research Project

Project/Area Number 17K17983
Research InstitutionFukushima Medical University

Principal Investigator

三坂 眞元  福島県立医科大学, 医学部, 講師 (10583635)

Project Period (FY) 2017-04-01 – 2021-03-31
Keywords薬食相互作用 / 食事性フラボノイド / 薬物トランスポーター / 薬物動態 / 臨床試験
Outline of Annual Research Achievements

本研究はエピガロカテキンガレート(EGCG)に代表される茶カテキンなど食事性フラボノイドと水溶性の薬物を併用した際に、フラボノイド類が小腸上皮における薬物の細胞膜透過を修飾することによって相互作用が生じうるとの仮説を臨床薬理学的に検証することを目的とした。
本年度はこれまでに実施した緑茶カテキンとナドロール、リシノプリル、フェキソフェナジンおよびプソイドエフェドリンとの相互作用試験についての研究成果を原著論文として発表した。

  • Research Products

    (4 results)

All 2021 2020

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results)

  • [Journal Article] Urinary Excretion of Nadolol as a Possible In Vivo Probe for Drug Interactions Involving P‐Glycoprotein2021

    • Author(s)
      Shimazaki Sho、Kuroda Junko、Shimomura Kenju、Misaka Shingen
    • Journal Title

      The Journal of Clinical Pharmacology

      Volume: 61 Pages: 799~805

    • DOI

      10.1002/jcph.1812

    • Peer Reviewed
  • [Journal Article] Impact of Green Tea Catechin Ingestion on the Pharmacokinetics of Lisinopril in Healthy Volunteers2020

    • Author(s)
      Misaka Shingen、Ono Yuko、Uchida Atsushi、Ono Tomoyuki、Abe Osamu、Ogata Hiroshi、Sato Hideyuki、Suzuki Masahiko、Onoue Satomi、Shikama Yayoi、Shimomura Kenju
    • Journal Title

      Clinical and Translational Science

      Volume: 14 Pages: 476~480

    • DOI

      10.1111/cts.12905

    • Peer Reviewed / Open Access
  • [Journal Article] Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers2020

    • Author(s)
      Misaka Shingen、Abe Osamu、Ono Tomoyuki、Ono Yuko、Ogata Hiroshi、Miura Itaru、Shikama Yayoi、Fromm Martin F.、Yabe Hirooki、Shimomura Kenju
    • Journal Title

      British Journal of Clinical Pharmacology

      Volume: 86 Pages: 2314~2318

    • DOI

      10.1111/bcp.14315

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Atorvastatin?Green Tea Interaction: Possible Mechanisms are Complicated, But Clinical Relevance is Not?2020

    • Author(s)
      Misaka Shingen、Shimomura Kenju
    • Journal Title

      European Journal of Drug Metabolism and Pharmacokinetics

      Volume: 45 Pages: 423~425

    • DOI

      10.1007/s13318-020-00620-w

URL: 

Published: 2021-12-27  

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