2019 Fiscal Year Annual Research Report
Pre-emptive Delivery of Pain Specific Local Anaesthetic (QX-CAP) to Prevent Endodontic Postoperative Pain
| Project/Area Number |
17K18209
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | QX314 / Capsaicin / Endodontic pain / Trigeminal nerve / c-Fos / TRPV1 |
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| Outline of Annual Research Achievements |
We investigated the possibility of using the combination of a derivative of lidocaine (QX314) & a TRPV1 activator (capsaicin), (QX-CAP) in reducing postoperative pain after endodontic treatment. We made an animal model to mimic endodontic treatment procedure. The dental pulp of the rat`s lower central incisor was exposed using dental drill and stimulated with an endodontic file to mimic the endodontic treatment procedure. A neuronal marker, c-Fos, expression increased in the trigeminal subnucleus caudalis (Vc) following the endodontic procedure compared to sham and naive rats, indicating increase of neuronal activity in the Vc due to the endodontic procedure. QX-CAP injection near the mandibular and mental nerve areas reduced the number of c-Fos expressing neurons in the Vc in rats with endodontic procedure, indicating reduction of endodontic procedure-induced neuronal activation by QX-CAP injection.
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Research Products
(10 results)
