Magnetic resonance spectroscopy with optical frequency combs and its application to bio imaging

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K19099
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Physical chemistry, Functional solid state chemistry, and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Hiramatsu Kotaro 東京大学, 大学院理学系研究科(理学部), 助教 (60783561)
• Project Period (FY): 2017-06-30 – 2020-03-31
• Keywords: デュアルコム分光法 / 振動分光 / 磁気共鳴 / バイオイメージング / 高速分光法

Outline of Final Research Achievements

Bioimaging, which visualizes biomolecules in living cells and tissues, is an indispensable technology in modern life sciences. In particular, magnetic resonance imaging and vibrational spectroscopic imaging, which can measure cells and tissues without staining, are becoming increasingly important in applications such as regenerative medicine. In this study, we have developed magnetic resonance and vibrational spectroscopic imaging using a state-of-the-art laser technology, optical frequency combs. As for the magnetic resonance measurement, we developed a new device and tried to measure it, but unfortunately we could not detect the signal. For the dual-comb vibration spectroscopy measurement, the efficiency was improved by about 100 times compared to the conventional method.

Free Research Field

分子分光学

Academic Significance and Societal Importance of the Research Achievements

デュアルコム振動分光法は高速かつ無標識に生体分子を可視化できる手法として注目を集めている。その高効率化は今後のデュアルコム振動分光計測に基づく様々な生命科学・物質科学的発見を加速することが期待される。また、計測の効率をほぼ100%まで高めたことは、本手法における感度・速度の限界を達成したことを意味しており、分子分光学のマイルストーン的意義も大きい。