Exploration of extracellular vesicles with long blood retention time and evaluateion of its physiological function

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K19390
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Biology of Cells to Organisms, and related fields
• Research Institution: Kyoto University
• Principal Investigator: Takahashi Yuki 京都大学, 薬学研究科, 准教授 (00547870)
• Project Period (FY): 2017-06-30 – 2019-03-31
• Keywords: 細胞由来小胞 / エキソソーム / ルシフェラーゼ

Outline of Final Research Achievements

Recently, it was found that cells release various types of cell-derived particles such as vesicles known as exosomes. In this study, cell-derived particles with long retention time in blood was explored by evaluating blood circulation half-life of cell-derived particle samples prepared by separation using various methods. As a result, cell-derived particles with long retention time in blood was found.

Free Research Field

生物薬剤学

Academic Significance and Societal Importance of the Research Achievements

本研究では、新規の血中滞留性の高い細胞由来微粒子の発見に成功した。このような微粒子は、生体内で未知の機能を有している可能性が存在することから、新規の細胞機能の発見につながる可能性がある。また、このような血中滞留性の高い細胞由来微粒子の性質を明らかとすることができれば、優れたデリバリーキャリアの創出も可能になり、優れた治療法の開発にもつながると期待できる。