Investigation of the mechanism underlying the association between DSB repair and Transcription

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K19615
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology and related fields
• Research Institution: Tokyo University of Technology
• Principal Investigator: UI Ayako 東京工科大学, 応用生物学部, 准教授 (00469967)
• Project Period (FY): 2017-06-30 – 2019-03-31
• Keywords: ＤＮＡ修復

Outline of Final Research Achievements

DSB (DNA double strand break) is one of harmful DNA damage that induces cancer. Recently, DSB-induces transcriptional repression prevents genome instability and cancer. In this study, we investigated the relationship between DSB-induced transcriptional repression, DSB repair and transcription. We found that factors of histone ubiquitination which have been reported to be involved in transcription and DSB repair are required for DSB-induced transcriptional repression. In addition, we identify the histone modifications that are required for DSB-induced transcriptional repression. These findings may be an important information to reveal the mechanism of genome instability and cancer.

Free Research Field

ＤＮＡ修復

Academic Significance and Societal Importance of the Research Achievements

近年、ＤＳＢ依存的に起こる転写抑制は、ゲノム安定性維持と細胞がん化の抑制に重要な役割を果たすことが明らかになってきている。そこで本研究の成果は、ゲノム安定性維持のメカニズムの解明による細胞がん化機構の解明につながると考えられる。