2018 Fiscal Year Final Research Report
Development of bone-organod and its application for the research in bone diseases
| Project/Area Number |
17K19725
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgery related to the biological and sensory functions and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
TOGUCHIDA JUNYA 京都大学, ウイルス・再生医科学研究所, 教授 (40273502)
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| Co-Investigator(Kenkyū-buntansha) |
吉富 啓之 京都大学, ウイルス・再生医科学研究所, 准教授 (50402920)
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| Research Collaborator |
ADACHI Taiji
ALEV Cantas
KAWAI Shunsuke
NIWA Akira
MATSUDA Shuichi
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Keywords | オルガノイド / IPS細胞 / 骨改変 / 骨疾患 |
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| Outline of Final Research Achievements |
We established a method to make bone-like nodules from human iPS cells within 10 days using retinoic acid signal, and observed this process by the time-lapse imaging. We also succeeded to visualize the differentiation process from osteoblasts to osteocytes using collagen gel culture system, and demonstrated that the induction method and experimental system are useful for disease-modeling and drug screening using patient-specific iPS cells of osteogenesis imperfecta.
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| Free Research Field |
幹細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
学術的意義としては、骨代謝研究分野における新しいin vitroでの解析システムとして極めて有用なものである。社会的意義としては、難治性の骨疾患に対する病態解明から創薬へのプロセスに有用なものであり、有効な治療薬の無い疾患における患者の臨床病態の改善に貢献できる可能性がある。
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