2018 Fiscal Year Final Research Report
Comprehensive search for biomarkers predicting dementia using urine metabolomics analysis
| Project/Area Number |
17K19799
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Society medicine, Nursing, and related fields
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡邊 裕美 新潟大学, 医歯学系, 講師 (50325479)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEUCHI Takeshi 新潟大学, 医歯学系, 教授
YAMAMOTO Tadashi 新潟大学, 医歯学系, 特任教授
KABASAWA Keiko 新潟大学, 医歯学系, 特任助教
KITAMURA Kaori 新潟大学, 医歯学系, 助教
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| Project Period (FY) |
2017-06-30 – 2019-03-31
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| Keywords | アルツハイマー病 / メタボロミクス / 尿 / バイオマーカー / 予防 |
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| Outline of Final Research Achievements |
This study aimed to determine specific urine biomarkers of Alzheimer disease (AD) by using metabolomics. Urine samples of 9 AD patients and 9 controls were analyzed with predictive model and validation model. Two and 7 metabolites were increased and decreased, respectively in predictive model, and 3 and 6 metabolites, respectively, were in validation model. Especially, glycerol-3-phosphate was significantly decreased in the both model. It is suggested that urine glycerol-3-phosphate is a new biomarker.
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| Free Research Field |
予防医学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で見出された尿中glycerol-3-phosphateは、アルツハイマー病の新たなバイオマーカーの可能性があり、尿でアルツハイマー病が予測できることが期待される。また同時に、glycerol-3-phosphateが減少したことはアルツハイマー病におけるリン脂質代謝の異常を反映している可能性がある。今後は尿中の脂溶性代謝産物の変化についての解析を行うことが重要と考える。
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