2019 Fiscal Year Final Research Report
| Project/Area Number |
17K19871
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Society medicine, Nursing, and related fields
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| Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
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Principal Investigator |
ryo ohtani (大谷良) 独立行政法人国立病院機構(京都医療センター臨床研究センター), 糖尿病研究部, 研究員 (80574657)
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| Project Period (FY) |
2017-06-30 – 2020-03-31
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| Keywords | Alzheimer’s disease / HDL subfraction / high-density lipoprotein / inflammation / cognitive impairment |
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| Outline of Final Research Achievements |
High-density lipoprotein (HDL) containing apolipoprotein A-I is associated with the pathogenesis of Alzheimer's disease (AD).The aim of this study was to investigate the HDL lipoprotein subclasses in mild cognitive impairment (MCI) and AD. This cross-sectional study included 20 AD patients, 17 MCI patients, and 17 age-matched controls without cognitive impairment, selected from the database of the Study of Outcome and aPolipoproteins in Dementia (STOP-Dementia) registry. Small-sized HDL particle levels in the MCI group were significantly higher than in the control group, although there was no difference in serum HDL-cholesterol levels between MCI and control groups. NLR in the MCI group was higher than in the control group, but this difference was non-significant. There was no difference in HDL subclasses or NLR between the AD and control groups. These findings suggest that HDL subclasses might be associated with the development of MCI.
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| Free Research Field |
神経内科学
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| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー病の早期発見や抗認知症薬に関する研究は進んでいるが、アミロイドβの産生機構に関する基礎的研究も進んでいる。本研究から、軽度認知症の発症にHDLのサブクラスが関与していることが明らかとなった。また、本研究の成果として「ストップ認知症プロジェクト」のデータベースを完成することができた。このデータベースを利用することで、GWASやEWAS、さらにはリピドミクスを駆使することで、アミロイドβの排泄機構の解明されることが期待される。
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