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2020 Fiscal Year Final Research Report

Development of new therapy for joint contractures using percutaneous carbon dioxide application.

Research Project

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Project/Area Number 17K19908
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Research Field Health science and related fields
Research InstitutionKobe University

Principal Investigator

Akisue Toshihiro  神戸大学, 保健学研究科, 教授 (90379363)

Co-Investigator(Kenkyū-buntansha) 森山 英樹  神戸大学, 保健学研究科, 教授 (10438111)
河本 旭哉  神戸大学, 医学研究科, 特命講師 (30420558)
原 仁美  神戸大学, 医学部附属病院, 助教 (40437489)
新倉 隆宏  神戸大学, 医学研究科, 准教授 (40448171)
酒井 良忠  神戸大学, 医学研究科, 特命教授 (90397802)
Project Period (FY) 2017-06-30 – 2021-03-31
Keywords炭酸ガス / 関節拘縮 / 中枢性麻痺 / 関節固定
Outline of Final Research Achievements

Joint contractures are a major complication following injuries in central nervous system or joint immobilization. However, no effective treatment has been developed so far. In the present study, we aimed to develop a novel therapeutic approach for joint contractures using transcutaneous carbon dioxide absorption. Our findings indicate that transcutaneous carbon dioxide may improve knee range of motion after injuries central nervous system or joint immobilization. We also revealed that transcutaneous carbon dioxide decreases muscular and articular fibrosis, thereby improving knee joint contracture.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

本研究により得られた知見から、炭酸ガス経皮吸収が、関節拘縮に対する新たな非侵襲的治療戦略になる可能性をもつことが示された。従来、関節拘縮の治療に用いられてきた物理療法やストレッチ等と、この治療法を併用することで、より優れた治療法となる可能性を秘めている。

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Published: 2022-01-27  

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