2020 Fiscal Year Final Research Report
Effect of combination of endurance training and anti-inflammatory/antioxidant administration on mitochondrial biogenesis in skeletal muscle
| Project/Area Number |
17K19936
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Health science and related fields
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Project Period (FY) |
2017-06-30 – 2021-03-31
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| Keywords | 高脂肪食 / 炎症性サイトカイン / メラトニン / 持久的トレーニング / 筋組織 / 体重 |
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| Outline of Final Research Achievements |
This study examined the effects of a combination of exercise training and anti-inflammatory/antioxidant administration on physical characteristics and mitochondrial biogenesis in a high fat diet-induced obese animal model. In the model, the combination of exercise training and melatonin administration resulted in the most significant weight loss as compared to the control group or either individual factor. However, the weight of muscle tissue, adipose tissue, and mitochondria volume did not follow these changes, suggesting that the mechanism of the combination of exercise training and melatonin administration needs to be investigated in further detail.
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| Free Research Field |
スポーツ生化学
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| Academic Significance and Societal Importance of the Research Achievements |
肥満や糖尿病などによる体内環境の変化がトレーニング効果獲得の阻害因子を増加させるのであれば、それを抑制しながら運動トレーニングが実施できれば、トレーニング効果が改善、助長される可能性が考えられ、運動療法の価値が高まることも考えられる。また、これまでに運動トレーニングによるミトコンドリア生合成の促進を阻害する因子の抑制によってミトコンドリア生合成の反応を改善、亢進できれば、新たな観点からの運動処方、トレーニング方法の開発にも寄与できるかもしれない。
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