2022 Fiscal Year Final Research Report
RNA-chromatin interaction prediction and application
| Project/Area Number |
17K20032
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied informatics and related fields
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩切 淳一 東京大学, 大学院新領域創成科学研究科, 助教 (40770160)
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| Project Period (FY) |
2017-06-30 – 2023-03-31
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| Keywords | ノンコーディングRNA / lncRNA / R-loop / 分子間相互作用 / リピート要素 |
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| Outline of Final Research Achievements |
We found different repetitive elements associated with R-loop formation in different species. Satellites, LINEs, and DNA transposons were found to be specifically enriched in R-loops in human, Drosophila, and Arabidopsis, respectively. R-loops tended to occur in regions of low complexity or simple repeats across species, and the repeat elements associated with R-loop formation were found to vary by developmental stage. For example, LINE and long terminal repeat retrotransposons (LTRs) were found to be more likely to contain R-loops in embryos and low complexity or simple repeats in postdevelopmental S2 cells.
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| Free Research Field |
バイオインフォマティクス
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| Academic Significance and Societal Importance of the Research Achievements |
RNAとクロマチンの相互作用のひとつであるRループ構造と従来はジャンクだと考えられていたリピート要素との関連性を，バイオインフォマティクス的なアプローチにより包括的に解析を行った．Rループは疾患などのさまざまな生命現象に深く寄与していることが考えられるため，われわれの研究結果は今までわかっていなかった生命分子メカニズムの解明に寄与することが期待される．
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