The effects of genetic factors on skeletal muscle and joint functions before and after eccentric contractions

2021 Fiscal Year Annual Research Report

• Project/Area Number: 17KK0073
• Research Institution: Hosei University
• Principal Investigator: 越智 英輔 法政大学, 生命科学部, 准教授 (90468778)
• Project Period (FY): 2018 – 2021
• Keywords: 筋損傷 / 筋再生 / 遺伝子改変 / サテライト細胞

Outline of Annual Research Achievements

本研究では、基課題で得られた知見から、特定の遺伝子を欠損した実験動物あるいはヒト生体を対象として、遺伝的要因が軟部組織(筋、神経、血管)及び筋損傷 導入前後の骨格筋・関節機能におよぼす影響を検討することを目的としている。本年度は、抗加齢マウスモデルの骨格筋および結合組織の伸張性収縮を含む運動応答を検討した。渡航先が保有するKlothoトランスジェニックマウス64匹およびwt 54匹を対象とし、運動負荷による筋損傷を誘発した。運動8週後に解剖し、筋サンプルを採取した。その結果、筋湿重量には差が認められなかったものの、Wntシグナルの活性化が変化すること、Pax7陽性細胞の増加、などが観察された。

Research Products

• [Int'l Joint Research] カリフォルニア大学ロサンゼルス校(米国) (2019)
  • Year and Date: 2019-03-24 – 2021-03-19
  • Country Name: U.S.A.
  • Counterpart Institution: カリフォルニア大学ロサンゼルス校
  • Co-investigator Overseas: James G. Tidball
  • Department: 統合生理生物学部
  • Job Title: 教授
• [Journal Article] Accuracy of exercise-based tests for estimating cardiorespiratory fitness and muscle strength in early-stage breast cancer survivors in Japan (2022)
  • Author(s): Tsuji Katsunori、Matsuoka Yutaka J.、Kuchiba Aya、Suto Akihiko、Ochi Eisuke
  • Journal Title: Supportive Care in Cancer Volume: 30 Pages: 3105~3118
  • DOI: 10.1007/s00520-022-06811-2
  • Peer Reviewed
• [Journal Article] Eccentric exercise causes delayed sensory nerve conduction velocity but no repeated bout effect in the flexor pollicis brevis muscles (2021)
  • Author(s): Ochi Eisuke、Ueda Hisashi、Tsuchiya Yosuke、Nakazato Koichi
  • Journal Title: European Journal of Applied Physiology Volume: 121 Pages: 3069～3081
  • DOI: 10.1007/s00421-021-04773-7
  • Peer Reviewed
• [Journal Article] Cardiorespiratory fitness in breast cancer survivors: a randomised controlled trial of home-based smartphone supported high intensity interval training (2021)
  • Author(s): Ochi Eisuke、Tsuji Katsunori、Narisawa Tomomi、Shimizu Yoichi、Kuchiba Aya、Suto Akihiko、Jimbo Kenjiro、Takayama Shin、Ueno Taro、Sakurai Naomi、Matsuoka Yutaka
  • Journal Title: BMJ Supportive & Palliative Care Volume: 12 Pages: 33～37
  • DOI: 10.1136/bmjspcare-2021-003141
  • Peer Reviewed / Open Access
• [Journal Article] Impact of a single bout of resistance exercise on serum Klotho in healthy young men (2021)
  • Author(s): Morishima Takuma、Ochi Eisuke
  • Journal Title: Physiological Reports Volume: 9 Pages: e15087
  • DOI: 10.14814/phy2.15087
  • Peer Reviewed / Open Access
• [Journal Article] Comorbid insomnia among breast cancer survivors and its prediction using machine learning: a nationwide study in Japan (2021)
  • Author(s): Ueno Taro、Ichikawa Daisuke、Shimizu Yoichi、Narisawa Tomomi、Tsuji Katsunori、Ochi Eisuke、Sakurai Naomi、Iwata Hiroji、Matsuoka Yutaka J
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 52 Pages: 39～46
  • DOI: 10.1093/jjco/hyab169
  • Peer Reviewed
• [Journal Article] Polyunsaturated Fatty Acids, Exercise, and Cancer-Related Fatigue in Breast Cancer Survivors (2021)
  • Author(s): Matsuoka Yutaka、Tsuji Katsunori、Ochi Eisuke
  • Journal Title: Frontiers in Physiology Volume: 12 Pages: 759280
  • DOI: 10.3389/fphys.2021.759280
  • Peer Reviewed / Open Access
• [Journal Article] Oncology care providers’ awareness and practice related to physical activity promotion for breast cancer survivors and barriers and facilitators to such promotion: a nationwide cross-sectional web-based survey (2021)
  • Author(s): Shimizu Yoichi、Tsuji Katsunori、Ochi Eisuke、Okubo Ryo、Kuchiba Aya、Shimazu Taichi、Tatematsu Noriatsu、Sakurai Naomi、Iwata Hiroji、Matsuoka Yutaka J.
  • Journal Title: Supportive Care in Cancer Volume: 30 Pages: 3857～3863
  • DOI: 10.1007/s00520-021-06706-8
  • Peer Reviewed
• [Presentation] Expectations of home-based exercise research for enhancing cancer survivorship care. (2022)
  • Author(s): Matsuoka YJ, Tsuji K, Ochi E.
  • Organizer: 第19回日本臨床腫瘍学会
  • Invited
• [Presentation] Effect of home-based high-intensity interval training and behavioral modification using information and communication technology on cardiorespiratory fitness and exercise habits among sedentary breast cancer survivors: the habit-B randomized controlled trial in progress. (2021)
  • Author(s): Tsuji K, Ochi E, Shimizu Y, Kuchiba A, Narisawa T, Okubo R, Ueno T, Shimazu T, Kinoshita T, Suto A, Sakurai N, Matsuoka Y
  • Organizer: 22nd World Congress of Psycho-Oncology & Psychosocial Academy
  • Int'l Joint Research
• [Presentation] Association between physical activity and fear of cancer recurrence in breast cancer survivors: a nationwide cross-sectional study. (2021)
  • Author(s): Narisawa T, Shimizu Y, Tsuji K, Ochi E, Okubo R, Kuchiba A, Sakurai N, Ueno T, Iwata H, Matsuoka Y.
  • Organizer: 22nd World Congress of Psycho-Oncology & Psychosocial Academy
  • Int'l Joint Research
• [Presentation] 簡易評価法による日本人乳がんサバイバーにおける最高酸素摂取量の予測可能性 (2021)
  • Author(s): 街勝憲, 松岡豊, 口羽文, 首藤昭彦, 越智英輔
  • Organizer: 第76回日本体力医学会
• [Presentation] Effect of home-based smartphone- supported high-intensity interval training on cardiorespiratory fitness in breast cancer survivors: A randomized controlled trial of the habit-B program. (2021)
  • Author(s): Ochi E, Tsuji K, Narisawa T, Shimizu Y, Kuchiba A, Suto A, Jimbo K, Takayama S, Ueno T, Sakurai N, Matsuoka Y.
  • Organizer: 44nd Annual San Antonio Breast Cancer Symposium (SABCS)
  • Int'l Joint Research
• [Presentation] High-intensity interval training in breast cancer survivors: A systematic review. (2021)
  • Author(s): Tsuji K, Matsuoka YJ, Ochi E.
  • Organizer: 44nd Annual San Antonio Breast Cancer Symposium (SABCS)
  • Int'l Joint Research