2023 Fiscal Year Final Research Report
Study of long noncoding RNA in innate immune response
| Project/Area Number |
17KK0163
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2018 – 2023
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| Keywords | RNA / 自然免疫 |
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| Outline of Final Research Achievements |
To elucidate the function of long non-coding RNAs that regulate innate immune responses and their nuclear metabolic control in mammalian cells, we conducted international collaborative research with Dr. Torben in Denmark, an expert in nuclear RNA degradation mechanisms, and Dr. Atasoy in the United States, an expert in immune responses. As a result, we discovered that the nuclear degradation of NEAT1, a long non-coding RNA that regulates innate immune responses, is controlled by hnRNPH, a nucler RNA binding protein. We have published our findings in a scientific journal. Furthermore, we also discovered a new mechanism related to the nuclear degradation of messenger RNA and are currently continuing our collaborative research.
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| Free Research Field |
薬学、分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
免疫応答の仕組みを解明することは、基礎生物学の発展のみならず、医学・薬学の発展に不可欠である。そのため、免疫応答の仕組みを分子レベルで解明する本研究は、基礎から応用まで幅広いインパクトがある。また、このように重要な研究領域で日本が国際的リーダーシップを発揮してゆくためには、多国間国際共同研究を実施し、最新の科学的知見を共有し、そのうえで、新しい知見を発見することが重要である。このような観点から、免疫応答の専門家やRNA代謝制御の専門家と国際共同研究チームを構築できたことは本邦にとって大きな意義がある。
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