大規模コホート研究による稀少がんと生活習慣との関連の検討

2007 Fiscal Year Annual Research Report

• Project/Area Number: 18014011
• Research Institution: Aichi Medical University
• Principal Investigator: 玉腰 暁子 Aichi Medical University, 医学部, 准教授 (90236737)
• Co-Investigator(Kenkyū-buntansha): 坂田 清美 岩手医科大学, 医学部, 教授 (50225794) ; 坂内 文男 札幌医科大学, 医学部, 准教授 (60325868) ; 小笹 晃太郎 京都府立医科大学, 医学研究科, 准教授 (20204191)
• Keywords: コホート研究 / がん / 稀少がん / 死亡 / 危険因子 / 生活習慣

Research Abstract

多施設共同の大規模なコホート研究Japan Collaborative Cohort Study(JACC Study)【1988年から90年に40-79歳の男女約11万人を対象に開始】の追跡を行い、ベースラインデータ、中間調査データなど基礎となる情報に死亡・転出・がん罹患(追跡調査)データをマージし、解析用データセットを作成した。2003年までの死亡追跡により、食道がんは203例、卵巣がんは89例、腎がん(腎盂も含む)93例、骨髄性白血病87例などとなっている。また、2001年までの罹患数は食道がん99例、子宮体がん69例、卵巣がん48例、腎がん(腎盂も含む)79例、甲状腺がん118例、多発性骨髄腫31例などである(罹患把握地域が限定されているため、死亡数に比べ数が少ない)。今年度の成果として、口腔・咽頭がんのリスクは喫煙により男性で2.6倍、女性で8.2倍増加すること、飲酒は1日当たり2合以上の場合に男性で3.2倍のリスク上昇と関連することが明らかとなった。一方で、緑茶飲用は口腔がんのリスク低下と関連し、特に女性で1日5杯以上飲む群は1日1杯未満群とくらベリスクが0.31倍に低下していた。緑茶を飲む習慣のある日本でこのような成果の出た意義は大きい。卵巣がん死亡といくつかの生活習慣との関連を検討したところ、肥満、妊娠・出産経験のないことが危険要因として、運動習慣、豆腐摂取が予防要因としてはたらいている可能性が示唆された。また、腎がんの検討では、糖尿病が腎がんのリスクを上げる可能性が認められた。さらに続けて詳細な検討が必要と考えている。
今年度は死亡追加のため総務省に人口動態統計資料の目的外利用申請を行い、平成20年に入って承認を得た。現在、申請書に従い各地区で死亡・転出を調査中である。なお、各施設と事務局との情報のやり取りには個人識別情報は外してIDを用いている。

Research Products

• [Journal Article] Cigarette smoking, alcohol drinking, and oral and pharyngeal cancer mortality in Japan (2008)
  • Author(s): IIde R, Mizoue T, Fujino Y, Hoshiyama Y, Sakata K, TamakoshiA, Yoshimura T, for the JACC Study Group
  • Journal Title: Oral Diseases 14 Pages: 314-9
  • Peer Reviewed
• [Journal Article] Obesity, physical activity and the risk of pancreatic cancer in a large Japanese cohort (2008)
  • Author(s): LinY, Kikuchi S, Tamakoshi A, Yagyu K, Obata Y, Inaba Y, Kurosawa M, Kawamura T, Motohashi Y, Ishibashi T, for the JACC StudyGroup
  • Journal Title: Int J Cancer 120 Pages: 2665-2671
  • Peer Reviewed
• [Journal Article] Active smoking, passive smoking and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (2008)
  • Author(s): Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Mori M, Tamakoshi A, for the Japan Collaborative Cohort Study Group
  • Journal Title: J Epidemiol (in press)
  • Peer Reviewed
• [Journal Article] Occupational Factors and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer(JACC) (2007)
  • Author(s): Fujino Y.
  • Journal Title: Asian Pac J Cancer Prev 8 Pages: 97-104
  • Peer Reviewed
• [Journal Article] A prospective study of green tea consumption and oral cancer incidence in Japan (2007)
  • Author(s): IdeR, Fujino Y, Hoshiyama Y, MizoueT, Kubo T, Pham T-M, Shirane K, Tokui N, SakataK, Tamakoshi A, Yoshimura T, for the JACC Study Group
  • Journal Title: Ann Epidemiol 17 Pages: 821-826
  • Peer Reviewed
• [Journal Article] Family History and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer(JACC) (2007)
  • Author(s): Kikuchi S
  • Journal Title: Asian Pac J Cancer Prev 8 Pages: 21-24
  • Peer Reviewed
• [Journal Article] Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study(JACC Study) (2007)
  • Author(s): Kondo T, Hori Y, Yatsuya H, Tamakoshi K, Toyoshima H, Nishino Y, Seki N, ItoY, Suzuki K, OzasaK, Watanabe Y, Ando M, Wakai K, Tamakoshi A, for the JACC Study Group
  • Journal Title: Cancer Causes Control 18 Pages: 229-234
  • Peer Reviewed
• [Journal Article] Green tea consumption and the risk of pancreatic cancer in Japanese adults (2007)
  • Author(s): Lin Y, Kikuchi S, Tamakoshi A, Yagyu K, Obata Y, Kurosawa M, Inaba Y, Kawamura T, Motohashi Y, Ishibashi T, for the JACC Study Group
  • Journal Title: Pancreas (in press)
  • Peer Reviewed
• [Journal Article] Consumption of soy foods and the risk of breast cancer: findings from the Japanese Collaborative Cohort(JACC) Study (2007)
  • Author(s): Nishio K, Niwa Y, Toyoshima H, Tamakoshi K, Kondo T, Yatsuya H, Yamamoto A, Suzuki S, Tokudome S, Lin Y, Wakai K, Hamajima N, Tamakoshi A
  • Journal Title: Cancer Causes Control 18 Pages: 801-808
  • Peer Reviewed
• [Journal Article] Smoking and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer(JACC) (2007)
  • Author(s): Ozasa K.
  • Journal Title: Asian Pac J Cancer Prev 8 Pages: 89-96
  • Peer Reviewed
• [Journal Article] A nested case-control study of stomach cancer incidence and serum superoxide dismutase activity in the Japan Collaborative Cohort study in Japan (2007)
  • Author(s): Pham T-M, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Kubo T, Matsuda S, Yoshimura T, for the JACC Study Group
  • Journal Title: Cancer Detect Prev 31 Pages: 431-435
  • Peer Reviewed
• [Journal Article] A nested case-control study of stomach cancer and serum insulin-like growth factor(IGF)-l, IGF-2 and IGF-binding protein(IGFBP)-3 (2007)
  • Author(s): Pham T-M, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Matsuda S, Yoshimura T, The JACC Study Group
  • Journal Title: Eur J Cancer 43 Pages: 1611-1616
  • Peer Reviewed
• [Journal Article] Dietary Habits and Risk of Ovarian Cancer Death in a Large-Scale Cohort Study(JACC Study)in Japan (2007)
  • Author(s): Sakauchi F, Khan M, Mori M, Kubo T, Fujino Y, Suzuki S, Tokudome S, Tamakoshi A, for the JACC Study Group
  • Journal Title: Nutr Cancer 57 Pages: 138-145
  • Peer Reviewed
• [Journal Article] Marital Status and Having Children and Mortality in the Japan Collaborative Cohort Study for Evaluation of Cancer(JACC) (2007)
  • Author(s): Sakauchi F
  • Journal Title: Asian Pac J Cancer Prev 8 Pages: 123-128
  • Peer Reviewed
• [Journal Article] Dietary fiber and risk of colorectal cancer in the Japan Collaborative Cohort (JACC) Study (2007)
  • Author(s): Wakai K, Date C, Fukui M, Tamakoshi K, Watanabe Y, Hayakawa N, Kojima M, Kawado M, Suzuki K, Hashimoto S, Tokudome S, Ozasa K Suzuki S, Toyoshima H, Ito Y, Tamakoshi A, for the JACC Study Group
  • Journal Title: Cancer Epidemiol Biomarkers Prev 16 Pages: 668-675
  • Peer Reviewed
• [Journal Article] Psychological attitudes and risk of breast cancer in Japan: a prospective study (2007)
  • Author(s): Wakai K, Kojima M, Nishio K, Suzuki S, Niwa Y, Lin Y, Kondo T, Yatsuya H, Tamakoshi K, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A, for the JACC Study Group
  • Journal Title: Cancer Causes Control 18 Pages: 259-267
  • Peer Reviewed
• [Journal Article] Liver cancer risk, coffee, and hepatitis C virus infection: a nested case-control study in Japan (2007)
  • Author(s): Wakai K, Kurozawa Y, Shibata A, Fujita Y, Kotani K, Ogimoto I, Naito M, Nishio K, Suzuki H, Yoshimura T, Tamakoshi A, for the JACC Study Group
  • Journal Title: Br J Cancer 97 Pages: 426-428
  • Peer Reviewed
• [Journal Article] Diabetes mellitus and kidney cancer risk: The results of Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) (2007)
  • Author(s): Washio M, Mori M, Khan M, Sakauchi F, Watanabe Y, Ozasa K, Hayashi K, Miki T, Nakao M, Mikami K, Ito Y, Kubo T, Wakai K, Tamakoshi A, for the JACC Study Group
  • Journal Title: Int J Urol 14 Pages: 393-397
  • Peer Reviewed
• [Journal Article] Hypertension and Other Risk Factors for the Development of Kidney Cancer (Renal Cell Carcinoma) in a Japanese Population: Findings from the JACC Study (2007)
  • Author(s): Washio M, all e
  • Journal Title: International Medical Jounal (in press)
  • Peer Reviewed
• [Journal Article] Cigarette smoking, alcohol drinking and the risk of gallbladder cancerdeath: A prospective cohort study in Japan (2007)
  • Author(s): Yagyu K, Kikuchi S, Obata Y, Lin Y, Ishibashi T, Kurosawa M, Inaba Y, Tamakoshi A, for the JACC Study Group
  • Journal Title: Int J Cancer 122 Pages: 924-929
  • Peer Reviewed
• [Presentation] Green tea consumption and the risk of pancreatic cancer in Japanese adults (2007)
  • Author(s): Lin Y, Kikuchi S, Tamakoshi A, Yagyu K, Obata Y, Inaba Y, Kurosawa M, Kawamura T, Motohashi Y, Ishibashi T, for the JACC Study Group
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-05
• [Presentation] Association of participation in screening for uterine or breast cancer with risk of death. Results from the JACC Study (2007)
  • Author(s): Mori M, Suzuki S, Tokudome S, Wakai K, Lin Y, Tamakoshi A
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-05
• [Presentation] Frequency of vegetable consumption and the risk of breast cancer: findings from the Japan Collaborative Cohort Study (2007)
  • Author(s): Nishio K, Lin Y, Suzuki S, Wakai K, Kubo T, Tokudome S, Mori M, Tamakoshi A
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-05
• [Presentation] Cancer incidence and consumption of vegetables and fruit: findings from the Japan Collaborative Cohort (JACC) Study (2007)
  • Author(s): Wakai K, Naito M, Nishio K, Tamakoshi A
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-05
• [Presentation] Green tea consumption and the risk of gallbladder cancer death in Japanese adults (2007)
  • Author(s): Yagyu K, Kikuchi S, Lin Y, Obata Y, Kurosawa M, Inaba Y, Tamakoshi A, for the JACC Study Group
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20071003-05
• [Presentation] Cigarette smoking, alcohol drinking and the risk of gallbladder cancer death: a prospective cohort study in Japan (2007)
  • Author(s): Yagyu K, Kikuchi S, Obata Y, Ishibashi T, Kurosawa M, Inaba Y, Tamakoshi A, the JACC Study Group
  • Organizer: The 14th European Cancer Conference Abstract, Barcelona, Spain
  • Place of Presentation: スペイン
  • Year and Date: 20070923-27
• [Presentation] Serum insulin and fructosamine level and pancreatic cancer risk: a nested case-control study in Japan (2007)
  • Author(s): Lin Y, Kikuchi S, Tamakoshi A, Obata Y, Yagyu K, Inaba Y, Kurosawa M, Kawamura T, Motohashi Y, Ishibashi T, for the JACC Study Group
  • Organizer: AACR Annual Meeting, Los Angeles, USA
  • Place of Presentation: アメリカ
  • Year and Date: 20070414-18
• [Remarks]
  • URL: http://www.aichi-med-u.ac.jp/jacc/index.html