Molecular basis for emotion and its role in higher brain functions and psychiatric and neurological disorders

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18100003
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: MANABE Toshiya The University of Tokyo, 医科学研究所, 教授 (70251212)
• Project Period (FY): 2006 – 2010
• Keywords: 脳・神経 / 脳神経疾患 / 行動学 / 遺伝子 / 生理学

Research Abstract

本研究計画では、恐怖などの情動の発現機構と情動異常が起こる原因を明らかにするために、各種の遺伝子改変マウスを作製し、その機能解析を進める。具体的には、電気生理学的なシナプス機能解析、生化学的解析、個体レベルでの神経行動学的解析を駆使して、情動が発現する分子・細胞機構や恐怖などの情動が記憶される機構、さらには、それらと情動異常を呈する精神神経疾患との関連性などの解明を目指す

Research Products

• [Journal Article] Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and LTP induction in the adult mouse CNS (2008)
  • Author(s): Miwa, H., Fukaya, M., Watabe, A. M., Watanabe, M.and Manabe, T.
  • Journal Title: J. Physiol.(Lond.) 586(peer reviewed) Pages: 2539-2550
• [Journal Article] Use-dependent amplification of presynaptic Ca^(2+) signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse (2008)
  • Author(s): Shimizu H., Fukaya, M., Yamasaki, M., Watanabe, M., Manabe, T.and Kamiya, H.
  • Journal Title: Proc. Natl. Acad.Sci. USA 105(peer reviewed) Pages: 11998-12003
• [Journal Article] GABAergic interneurons facilitate mossy fiber excitability in the developing hippocampus (2007)
  • Author(s): Nakamura, M., Sekino, Y.and Manabe, T.
  • Journal Title: J. Neurosci 27(peer reviewed) Pages: 1365-1373
• [Journal Article] The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation (2007)
  • Author(s): Bongsebandhu-phubhakdi, S.and Manabe,T.
  • Journal Title: J.Neurosci 27(peer reviewed) Pages: 4850-4858
• [Journal Article] NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity (2006)
  • Author(s): Nakazawa, T., Komai, S., Watabe, A. M.,Kiyama, Y., Fukaya, M.,Arima-Yoshida,F., Horai, R., Sudo, K., Ebine, K., Delawary, M., Goto, J., Umemori, H., Tezuka, T., Iwakura, Y., Watanabe, M., Yamamoto, T.and Manabe, T.
  • Journal Title: EMBO J. 25(peer reviewed) Pages: 2867-2877
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/NeuronalNetwork/Neuronal_Network/Index_japanese.htm
• [Remarks] Sakisaka et.al. Dual inhibition of SNARE complex formation by tomosyn ensures complex formation by tomosyn ensures controlled neurotransmitter release. J. Cell Biol. 183 : 323-337, 2008(F1000 Factor 6.0; October 28, 2008)
  • URL: http://www.f1000biology.com/guardpages/evaluation/1124834//article/article.asp%253Fid%253D1124834%2526view%253D%2526style%253D
• [Remarks] Nakazawa et.al. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.EMBO J. 25 : 2867-2877, 2006.(F1000 Factor 6.0 ; June 1, 2006)
  • URL: http://www.f1000biology.com/guardpages/evaluation/1032493//article/article.asp%253Fid%253D1032493%2526view%253D%2526style%253D