Behavioral state-dependent change in the information processing modes in the central olfactory system

2010 Fiscal Year Final Research Report

• Project/Area Number: 18100004
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: The University of Tokyo
• Principal Investigator: MORI Kensaku The University of Tokyo, 大学院・医学系研究科, 教授 (60008563)
• Co-Investigator(Kenkyū-buntansha): NAGAO Hiroshi 東京大学, 大学院・医学系研究科, 助教 (50281647) ; KASHIWADANI Hideki 東京大学, 大学院・医学系研究科, 助教 (70328376)
• Project Period (FY): 2006 – 2010
• Keywords: 分子・細胞神経科学 / 嗅覚神経系

Research Abstract

We found'Behavioral state-dependent change in the synaptic transmission in the olfactory bulb','Neuronal circuits for the sense of odor direction','Functional compartmentalization of the odor map in the olfactory bulb','During slow wave sleep, olfactory cortex generates sharp waves that travel to the olfactory bulb'and'Enhanced elimination of newly-generated granule cells during postprandial period.'

Research Products

• [Journal Article] Olfactory cortex generates synchronized top-down inputs to the olfactory bulb during slow-wave sleep. (2011)
  • Author(s): Manabe, H., Kusumoto-Yoshida, I., Ota, M., Mori, K.
  • Journal Title: J.Neurosci. 掲載確定(印刷中)
  • Peer Reviewed
• [Journal Article] Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb. (2011)
  • Author(s): Murata, M., Imai, M., Nakanishi S., Watanabe, D., Pastan I., Kobayashi, K., Nihira T., Mochizuki, H., Yamada, S., Mori, K., Yamaguchi, M.
  • Journal Title: J.Neurosci. 掲載確定(印刷中)
  • Peer Reviewed
• [Journal Article] Continuous neurogenesis in the adult forebrain is required for innate olfactory responses (2011)
  • Author(s): Sakamoto, M., Imayoshi, I., Ohtsuka,T., Yamaguchi, M, Mori, K., Kageyama, R.
  • Journal Title: Proc.Natl.Acad.Sci.USA 掲載確定(印刷中)
  • Peer Reviewed
• [Journal Article] How is the olfactory map formed and interpreted in the mammalian brain? (2011)
  • Author(s): Mori, K., Sakano, H.
  • Journal Title: Annu.Rev.Neurosci. 34掲載確定(印刷中)
  • Peer Reviewed
• [Journal Article] Genetic visualization of the secondary olfactory pathway in Tbx21 transgenic mice. (2011)
  • Author(s): Mitsui, S., Igarashi, K.M., Mori, K., Yoshihara, Y.
  • Journal Title: Neural Systems and Circuits 1 Pages: 5
  • Peer Reviewed
• [Journal Article] Two highly homologous mouse odorant receptors encoded by tandemly-linked MOR29A and MOR29B genes differently respond to phenyl ethers. (2011)
  • Author(s): Tsuboi, A., Imai, T., Kato, H.K., Matsumoto, H., Igarashi, K.M., Suzuki, M., Mori, K., Sakano, H.
  • Journal Title: European Journal of Neuroscience 33(2) Pages: 205-213
  • Peer Reviewed
• [Journal Article] Neurons in the anterior olfactory nucleus pars externa detect right and left localization of odor sources (2010)
  • Author(s): Kikuta S., Sato, K., Kashiwadani H., Tsunoda, K., Yamasoba, T, Mori K.
  • Journal Title: Proc.Natl.Acad.Sci.USA 107 Pages: 12363-12368
  • Peer Reviewed
• [Journal Article] Differential axonal projection of mitral and tufted cells in the mouse main olfactory system Frontiers (2010)
  • Author(s): Nagayama, S., Enerva A., Fletcher M.L., Masurkar A.V., Igarashi, K., Mori, K., Chen W.R.
  • Journal Title: Neural Circuits 4 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Spatial arrangement of glomerular molecular-feature clusters in the odorant-receptor-class domains of the mouse olfactory bulb (2010)
  • Author(s): Matsumoto, H., Kobayakawa, K., Kobayakawa, R., Tashiro T., Mori, K., Sakano, H., Mori, K.
  • Journal Title: J.Neurophysiol. 103 Pages: 3490-3500
  • Peer Reviewed
• [Journal Article] Essential roles of Notch signaling in maintenance of neural stem cells in the developing and adult brains (2010)
  • Author(s): Imayoshi, I., Sakamoto M., Yamaguchi, M., Mori, K., Kageyama, R.
  • Journal Title: J.Neurosci. 30(9) Pages: 3489-3498
  • Peer Reviewed
• [Journal Article] Development of the somatosensory cortex, the cerebellum, and the main olfactory system in Semaphorin 3F knockout mice. (2010)
  • Author(s): Matsuda, I., Fukaya, M., Nakao, H., Nakao, K., Matsumoto, H., Mori, K., Watanabe, M., Aiba, A.
  • Journal Title: Neurosci Res. 66(3) Pages: 321-329
  • Peer Reviewed
• [Journal Article] Behavioral state-dependent changes in the information processing mode in the olfactory system (2009)
  • Author(s): Tsuno Y., Mori K.
  • Journal Title: Communicative and Integrative Biology 2 Pages: 362-364
  • Peer Reviewed
• [Journal Article] Perisomatic-targeting granule cells in the mouse olfactory bulb (2009)
  • Author(s): Naritsuka H, Sakai K, Hashikawa T, Mori K., Yamaguchi, M.
  • Journal Title: J Comp Neurol. 515 Pages: 409-426
  • Peer Reviewed
• [Journal Article] Olfactory Bulb Mapping (2009)
  • Author(s): Mori K.
  • Journal Title: Encyclopedia of Neuroscience(Squire LR (ed.))(Oxford : Academic Press) volume 7 Pages: 71-75
  • Peer Reviewed
• [Journal Article] Odor-Induced Persistent Discharge of Mitral Cells in the Mouse Olfactory Bulb (2009)
  • Author(s): Matsumoto H, Kashiwadani H, Nagao H, Aiba A, Mori K.
  • Journal Title: J Neurophysiol. 101 Pages: 1890-1900
  • Peer Reviewed
• [Journal Article] Dendrodendritic synapses and functional compartmentalization in the olfactory bulb. (2009)
  • Author(s): Mori, K., Matsumoto, H., Tsuno, Y., Igarashi, K.M.
  • Journal Title: Annals of the New York Academy of Sciences 1170 Pages: 255-258
  • Peer Reviewed
• [Journal Article] Compensatory Rapid Switching of Binasal Inputs in the Olfactory Cortex (2008)
  • Author(s): Kikuta S, Kashiwadani H, Mori K
  • Journal Title: J Neurosci. 28 Pages: 11989-11997
  • Peer Reviewed
• [Journal Article] Behavioral state regulation of dendrodendritic synaptic inhibition in the olfactory bulb. (2008)
  • Author(s): Tsuno, Y., Kashiwadani, H., Mori, K.
  • Journal Title: J.Neurosci. 28 Pages: 9227-9238
  • Peer Reviewed
• [Journal Article] Long-term labeling and ablation reveal requirement of continuous neurogenesis for the structural and functional integrity of the adult forebrain. (2008)
  • Author(s): Imayoshi, I., Sakamoto, M., Ohtsuka T., Takao, K., Miyakawa, T., Yamaguchi, Y., Mori, K., Ikeda, T., Itohara, S., Kageyama, R.
  • Journal Title: Nature Neuroscienceq 11 Pages: 1153-1161
  • Peer Reviewed
• [Journal Article] A metric for odorant comparison. (2008)
  • Author(s): Haddad, R., Khan, R., Takahashi, Y.K., Mori, K., Harel, D., Sobel, N.
  • Journal Title: Nature Methods 5 Pages: 425-429
  • Peer Reviewed
• [Journal Article] Innate versus learned odor processing in the mouse olfactory bulb. (2007)
  • Author(s): Kobayakawa, K., Kobayakawa, R., Matsumoto, H., Oka, Y., Imai, T., Ikawa, M., Okabe, M., Ikeda, T., Itohara, S., Kikusui, T., Mori, K., Sakano, H.
  • Journal Title: Nature 450 Pages: 503-508
  • Peer Reviewed
• [Journal Article] Odorant category profile selectivity of olfactory cortex neurons. (2007)
  • Author(s): Yoshida, I., Mori, K.
  • Journal Title: J.Neuroscience 27(34) Pages: 9105-9114
  • Peer Reviewed
• [Journal Article] Maps of odorant molecular features in the mammalian olfactory bulb. (2006)
  • Author(s): Mori, K., Takahashi, Y.K., Igarashi, K.M., Yamaguchi, Y.
  • Journal Title: Physiological Reviews. 86(2) Pages: 409-433
  • Peer Reviewed
• [Journal Article] A leucine-rich repeat membrane protein 5T4 is expressed by a subtype of granule cells with dendritic arbor in specific strata of the mouse olfactory bulb. (2006)
  • Author(s): Imamura, F., Nagao, H., Naritsuka, H., Murata, Y., Taniguchi, H., Mori K.
  • Journal Title: J.Comp.Neurol. 495 Pages: 754-768
  • Peer Reviewed
• [Presentation] Olfactory cortex generates sharp waves that drive synchronized input to granule cells in the olfactory bulb during slow-wave sleep (2010)
  • Author(s): Manabe H., et al.
  • Organizer: Soc.for Neurosci.
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2010-11-16
• [Presentation] Olfactory bulb locally regulates incorporation of adult-born granule cell subsets (2010)
  • Author(s): Murata, K., et al.
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2010-11-13
• [Presentation] Olfactory cortex sharp waves during slow-wave sleep (2010)
  • Author(s): Manabe H., et al.
  • Organizer: 第8回国際シンポジウム「味覚嗅覚の分子機構」
  • Place of Presentation: 九州大学(福岡)
  • Year and Date: 2010-11-07
• [Presentation] Anterior olfactory nucleus pars externa detects the difference in the concentration of odorants between ipsi-nostril and contra-nostril inputs. (2010)
  • Author(s): Kikuta S., et al.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター(神戸)
  • Year and Date: 2010-09-03
• [Presentation] Parallel Mitral- and Tufted-Cell Streams in the Central Olfactory System (2010)
  • Author(s): Mori, K.
  • Organizer: The 56^<th> NIBB Conference
  • Place of Presentation: 岡崎基生研(岡崎)
  • Year and Date: 2010-03-12
• [Presentation] Mitral and tufted cell pathways from the olfactory bulb to the olfactory cortex (2009)
  • Author(s): Mori K.
  • Organizer: Beijing International Meeting on Research in Taste and Smell
  • Place of Presentation: Beijing (China)
  • Year and Date: 2009-11-16
• [Presentation] Segregation of olfactory information into mitral- and tufted-cell streams in olfactory cortex (2009)
  • Author(s): Igarashi, K., et al.
  • Organizer: Society for Neuroscience 2009
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2009-10-17
• [Presentation] Urine odor signals in the dorsal zone class II domain of the mouse main olfactory bulb (2009)
  • Author(s): Matsumoto, H., et al.
  • Organizer: Society for Neuroscience 2009
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2009-10-17
• [Presentation] Eating-related time window for apoptotic eleimination of adult-born neurons in the mouse olfactory bulb (2008)
  • Author(s): Yokoyama T., et al.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC (USA)
  • Year and Date: 2008-11-17
• [Presentation] Granule-to-mitral inhibition was stronger during sleep states in the rat olfactory bulb. (2008)
  • Author(s): Tsuno Y., et al.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC (USA)
  • Year and Date: 2008-11-17
• [Remarks] ホームページ
  • URL: http://morilab.m.u-tokyo.ac.jp/