2010 Fiscal Year Final Research Report
Explorations into development of bionic baroreflex system to overcome arterial pressure dysregulation in patients with cervical cord injury
| Project/Area Number |
18100006
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (S)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
SUNAGAWA Kenji Kyushu University, 医学研究院, 教授 (50163043)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIROOKA Yoshitaka 九州大学, 大学病院, 講師 (90284497)
TODAKA Koji 九州大学, 大学病院, 特任准教授 (40398061)
CHISYAKI Akiko 九州大学, 医学研究院, 教授 (60216497)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KAWADA Toru 国立循環器病研究センター, 研究所, 室長 (30243752)
|
|---|
| Project Period (FY) |
2006 – 2010
|
| Keywords | バイオニック医学 / 血圧制御 / 脊髄損傷 / 自動治療 / 生体医工学 |
|---|
| Research Abstract |
Central baroreflex failure in spinal cord injuries results in serious orthostatic hypotension. Even the latest medical science fails to provide a fundamental remedy for those patients. Since somatic inputs affect sympathetic activities, we examined if transcutaneous electrical stimulation can feedback control arterial pressure (bionic baroreflex system) in spinalized patients. We identified skin regions capable of increasing arterial pressure in response to electrical stimulation. We then determined the transfer function from the stimulation to arterial pressure responses and developed the bionic baroreflex system. The bionic baroreflex system fully prevented orthostatic hypotension in patients with spinal cord injuries.
|
Research Products
(43 results)
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity.2006
Author(s)
Michikami D, Kamiya A, Kawada T, Inagaki M, Shishido T, Yamamoto K, Ariumi H, Iwase S, Sugenoya J, Sunagawa K, Sugimachi M.
-
Journal Title
Am J Physiol Heart Circ Physiol. 291
Pages: H318-H326
-
-
-
-
-
-
-
-
-
[Presentation]2010
Author(s)
Hosokawa K, Kawada T, Ando M, Tanaka A, Sakamoto T, Onitsuka K, Murayama Y, Ide T, Sunagawa K.
Organizer
Experimental Biology 2010.
Place of Presentation
Anaheim, U.S.A.
Year and Date
2010-04-28
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Transcutaneous bionic baroreflex system is widely applicable for preventing severe orthostatic hypotension in patients with cervical cord injury.2008
Author(s)
Yoshida M, Chishaki A, Murayama Y, Kimura S, Ando M, Saito T, Shiba K, Shiino T, Todaka K, Sunagawa K.
Organizer
Scientific Sessions 2008 of the American Heart Association.
Place of Presentation
New Orleans, U.S.A.
Year and Date
2008-11-12
-
-
-
-
-
-
-
-
-
-
-
