2010 Fiscal Year Final Research Report
Functional Control by Modulating the Nucleic Acid Structure Based on Mismatch Base Pair Stabilization
| Project/Area Number |
18105006
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Osaka University |
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Principal Investigator |
NAKATANI Kazuhiko Osaka University, 産業科学研究所, 教授 (70237303)
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| Co-Investigator(Kenkyū-buntansha) |
DOHNO Chikara 大阪大学, 産業科学研究所, 准教授 (60420395)
HAGIHARA Masaki 大阪大学, 産業科学研究所, 助教 (40403000)
TAKEI Fumie 大阪大学, 産業科学研究所, 助教 (30252711)
ZHOU Daーyang 大阪大学, 産業科学研究所, 助教 (00324848)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 核酸 / 光制御 / ミスマッチ / 分子認識 / DNAナノ構造 / ナノテクノロジー |
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| Research Abstract |
We have established novel concept that small synthetic ligand, which selectively binds to DNA mismatch, could control higher order structures of DNA. DNA hybridization could be reversibly controlled by newly developed photoresponsive mismatch binding ligand, which allowed us to modulate various DNA-based functions depending on the ligand-specified DNA structures.
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