2010 Fiscal Year Final Research Report
Development of Techniques for Improvement of Silk Structure, Establishment of Mass Production, and Application to New Silk-based Materials for Bone and Teeth Regeneration
| Project/Area Number |
18105007
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
ASAKURA Tetsuo 東京農工大学, 大学院・工学研究院, 教授 (30139208)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAURA Chisato 東京農工大学, 大学院・工学研究院, 教授 (20138382)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 天然・生体高分子材料 / トランスジェニック絹 / 歯・骨再生 |
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| Research Abstract |
15 silk-like materials for tooth and bone regeneration were designed and produced by transgenic silkworm. Then the porous silk samples with different biodegradable characters were developed. Through in vitro evaluation by the cell cultivation and in vivo evaluation with animal implantation, the excellent materials for tooth and bone regeneration were developed on the basis of silk.
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[Journal Article] A novel carborane analog, BE360, with a carbon-containing polyhedral boron cluster is a new selective estrogen receptor modulator for bone2009
Author(s)
Hirata, M, Inada, M, Matsumoto, C. Takita, M, Ogawa, T., Endo, Y., Miyaura, C
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 380
Pages: 218-222
Peer Reviewed
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[Journal Article] Novel vitamin D-3 analogs, 1 alpha, 25(OH)(2) D-3-26, 23-lactam(DLAMs), antagonize bone resorption via suppressing RANKL expression in osteoblasts2008
Author(s)
Inada, M.; Tsukamoto, K.; Hirata, M.; Takita, M.; Nagasawa, K.; Miyaura, C.
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Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume: 372(3)
Pages: 434-439
Peer Reviewed
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[Journal Article] Solid-state NMR Analysis of(GA) 3S(AG) 3D(GA) 3S(GA) 3 D(GA) 3S(GA) 3, A Peptide with a Lamellar Structure and a Ca Binding Site, and Production of TS[(AG) 3D(GA) 3S] 16 in E. coli2007
Author(s)
Asakura, T.; Sato, H.; Moro, F.; Yang, M ; Nakazawa, Y., Collins, A. M.; Knight, D.
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Journal Title
Macromolecules
Volume: 40(25)
Pages: 8983-8990
Peer Reviewed
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[Remarks] TBS夢の扉+、「いのちを紡ぐ絹の糸」、平成23年1月29日報道関連情報
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[Remarks] HighlightingJAPAN, Highlighting JAPANVol.5, No2「The New Silk Road」平成23年6月1日報道関連情報
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[Remarks] BSジャパン、「世の中進歩堂」♯069、「シルク製再生医療材料研究」、平成22年1月24日報道関連情報
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