2009 Fiscal Year Final Research Report
Control and alteration of mitochondrial protein traffic
| Project/Area Number |
18107003
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
TOSHIYA Endo Nagoya University, 大学院・理学研究科, 教授 (70152014)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIHISA Tohru 名古屋大学, 物質理学国際研究センター, 准教授 (60212312)
NISHIKAWA ShuhーIchi 名古屋大学, 大学院・理学研究科, 准教授 (10252222)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 細胞小器官 / タンパク質輸送 |
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| Research Abstract |
To understand the mechanisms of the functions of mitochondrial protein translocators, which control the traffic of mitochondrial proteins, we have discovered a new maintenance factor Tam41, revealed the cooperation of receptors Tom20 and Tom22 in recognition of mitochondrial targeting signals, revealed the cooperation of translocators, the TOM40 complex and TIM23 complex, in transfer of mitochondrial precursor proteins, determined the high-resolution structure of the import motor assistant protein Tim15, analyzed the competition between the sorting signals for the outer membrane and matrix/inner membrane, achieved the interaction mapping of the outer membrane translocator subunit Tom22, and altered the signal recognition functions of the receptor Tom20.
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[Journal Article] Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria.2011
Author(s)
H.Yamamoto, N.Itch, S.Kawano, Y.Yatsukawa, T.Momose, T.Makio, M.Matsunaga, M.Yokota, M.Esaki, T.Shodai, D.Kohda, A.E.A.Hobbs, R.E.Jensen, T.Endo
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Journal Title
Proc.Natl.Acad.Sci.USA 108
Pages: 91-96
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