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2008 Fiscal Year Self-evaluation Report

Sequence Complementarity-Independent Functional RNAs

Research Project

  • PDF
Project/Area Number 18107005
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Biophysics
Research InstitutionThe University of Tokyo

Principal Investigator

NAKAMURA Yoshikazu  The University of Tokyo, 医科学研究所, 教授 (40114590)

Project Period (FY) 2006 – 2010
Keywords核酸の構造 / ノンコーディングRNA / アプタマー / 分子擬態
Research Abstract

本研究では、1) 試験管内進化法を用いた人工アプタマーの創成によるRNA機能の多角的研究開発と、2) ncRNAに内蔵された天然アプタマーの探索研究を実施して、相補性非依存型ncRNA研究の分子基盤を確立する。これらの研究成果を統合して、RNAの「造形力」という新概念を創成する。

  • Research Products

    (11 results)

All 2009 2008 2006 Other

All Journal Article (6 results) Presentation (1 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Aptamer-based biosensor for mammalian initiation factor eIF4A.2009

    • Author(s)
      Oguro, A., Ohtsu, T., Nakamura, Y.
    • Journal Title

      Anal. Biochem, 388

      Pages: 102-107

  • [Journal Article] Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population2008

    • Author(s)
      Wang, J., Takeuchi, H., Jin S., Sonobe Y., Shijie, J., Mizuno, T., Miyakawa, S., Fujiwara, M., Nakamura, Y., Kato, T., Muramatsu, H., Muramatsu, T., Suzumura, A.
    • Journal Title

      Proc. Natl. Acad. Sci. USA, 105

      Pages: 3915-3920

  • [Journal Article] Selection of a novel class of RNA-RNA interaction motifs based on the ligase ribozyme with defined modular architecture2008

    • Author(s)
      Ohuchi, S.P., Ikawa, Y., Nakamura, Y.
    • Journal Title

      Nucl. Acids Res 36

      Pages: 3600-3607

  • [Journal Article] Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin2008

    • Author(s)
      Miyakawa, S., Nomura, Y., Sakamoto, T., Yamaguchi, Y., Kato, K., Yamazaki, S., Nakamura, Y.
    • Journal Title

      G. RNA 14

      Pages: 1154-1163

  • [Journal Article] RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes2006

    • Author(s)
      Miyakawa, S., Oguro, A., Ohtsu, T., Imataka, H., Sonenberg, N., Nakamura, Y.
    • Journal Title

      RNA 12

      Pages: 1825-1834

  • [Journal Article] Structural insights into eRF3 and stop codon recognition by eRF1

    • Author(s)
      Cheng, Z., Saito, K., Pisarev, A.V., Wada, M., Pisareva, V.P., Pestova, T.V.. Gajda, M., Round, A., Kong, C., Lim, M., Nakamura, Y., Svergun, D.I., Ito, K., Song, H.
    • Journal Title

      Genes Dev. (In press)

  • [Presentation] RNA aptamer : fundamentals to therapeutics2008

    • Author(s)
      Nakamura, Y
    • Organizer
      Avison Biomedical Symposium 2008
    • Place of Presentation
      Yonsei University College of Medicine, Seoul他
    • Year and Date
      2008-01-17
  • [Book] RNA ルネッサンスー遺伝子新革命2006

    • Author(s)
      田原総一朗, 中村義一
    • Publisher
      医薬経済社
  • [Remarks] TV 出演:平成20年3月30日、中村義一テレビ番組「話題の医学」放映、「アプタマー医薬品」

  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/molbiol/H0.html

  • [Patent(Industrial Property Rights)] 免疫グロブリンG に結合する核酸とその利用法2006

    • Inventor(s)
      宮川伸, 中村義一
    • Filing Date
      2006-07-05

URL: 

Published: 2010-06-11   Modified: 2016-04-21  

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