2010 Fiscal Year Final Research Report
Molecular Mechanism of Anchorage-Dependent and-Independent Proliferation
Project/Area Number |
18109003
|
Research Category |
Grant-in-Aid for Scientific Research (S)
|
Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
|
Research Institution | The University of Tokyo |
Principal Investigator |
OKAYAMA Hiroto The University of Tokyo, 大学院・医学系研究科, 教授 (40111950)
|
Project Period (FY) |
2006 – 2010
|
Keywords | 癌 / 細胞周期 / シグナル伝達 / タンパク分解 / チェックポイント / mTORC1 |
Research Abstract |
Virtually all the cells composing solid organs of adult animals require an anchorage to the extracellular matrix and without this, arrest in G1 phase and die of apoptosis. Upon malignant transformation, these cells acquire the ability to proliferate without anchorage. This ability is generally believed to underlie their tumorigenicity. In this research project, we sought to understand the molecular mechanism controlling anchorage-dependent and-independent proliferation, which remains totally unknown, and now, the entire mechanism is largely understood. Consequently, a new, seemingly most effective target for anticancer therapy emerged.
|
-
-
[Journal Article] Mammalian Target of Rapamycin Complex 1 Signaling Opposes the Effects of Anchorage Loss, Leading to Activation of Cdk4 and Cdc6 Stabilization.2010
Author(s)
Arakawa-Takeuchi, S., Kobayashi, K., Park, J.-H., Uranbileg, B., Yamamoto, H., Jinno, S., Okayama, H.
-
Journal Title
FEBS Lett. 584
Pages: 2779-2785
Peer Reviewed
-
-
-
-
[Journal Article] Wilms' tumor 1-associating protein regulates G2_M transition through stabilization of cyclin A2 mRNA.2006
Author(s)
Horiuchi, K., Umetani, M., Minami, T., Okayama, H., Takada, S., Yamamoto, M., Aburatani, H., Reid, P.C., Housman, D.E., Hamakubo, T., Kodama, T.
-
Journal Title
Proc.Natl.Acad.Sci.USA 103
Pages: 17278-17283
Peer Reviewed
-
[Journal Article] Gene delivery by aminofullerenes : Structure requirement for efficient transfection.2006
Author(s)
Isobe, H., Nakanishi, W., Tomita, N., Jinno, S., Okayama, H., Nakamura, E.
-
Journal Title
Chemistry an Asian Journal 1
Pages: 168-175
Peer Reviewed
-
[Journal Article] Nonviral gene delivery by aminofullerene.2006
Author(s)
Isobe, H., Nakanishi, W., Tomita, N., Jinno S., Okayama, H., Nakamura, E.
-
Journal Title
Mol Pharm 3 3
Pages: 124-134
Peer Reviewed
-
-
-
-