2010 Fiscal Year Final Research Report
Dissemination mechanism of poliovirus
| Project/Area Number |
18109004
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NOMOTO Akio The University of Tokyo, 微生物化学研究所, 所長 (70112670)
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| Co-Investigator(Renkei-kenkyūsha) |
OHKA Seii 独立行政法人国立がん研究センター研究所, がん幹細胞研究分野, 研究員 (80313097)
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| Project Period (FY) |
2006 – 2010
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| Keywords | ウイルス / 感染症 / 生体分子 / 脳神経疾患 / 病理学 |
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| Research Abstract |
Poliovirus (PV) dissemination routes were investigated by using transgenic mice susceptible to PV and rodent cells. Main interests were i) low efficiency of oral infection, ii) PV permeation mechanism through blood brain barrier, iii) PV transportation mechanism of retrograde axonal pathway, and iv) PV resistance character of neural cells. Our data indicate that PV utilizes transferrin receptor to invade the central nervous system (CNS), and that PV is retrogradely transported both by PV receptor dependent- and independent-pathways through the axon.
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Research Products
(16 results)
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[Presentation] Mechanisms for neural dissemination of poliovirus.2006
Author(s)
Seii Ohka, Mai Sakai, Norie Matsuda, Koujiro Tohyama, Hiroko Igarashi, Stephanie Bohnert, Giampietro Schiavo, Akio Nomoto
Organizer
20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
Place of Presentation
Kyoto International Conference Center
Year and Date
2006-06-19
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