2010 Fiscal Year Final Research Report
The mechanisms of development and differentiation in Valpha14 NKT cells
| Project/Area Number |
18109006
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TANIGUCHI Masaru The Institute of Physical and Chemical Research, 免疫制御研究グループ, グループディレクター (80110310)
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| Co-Investigator(Kenkyū-buntansha) |
WATARAI Hiroshi 独立行政法人理化学研究所, 免疫制御研究グループ, 上級研究員 (70415339)
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| Project Period (FY) |
2006 – 2010
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| Keywords | NKT細胞 / クローンマウス / 初期分化 / 前駆細胞 / NKT細胞-GFPマウス / ES細胞 / iPS細胞 |
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| Research Abstract |
CD1d-restricted invariant natural killer T (NKT) cells bridge innate and acquired immunity and play an important role in both protective and regulatory responses. However, the developmental progression of NKT cells remains unclear. In the present study, we have demonstrated that NKT cell precursors that express invariant Vα14-Jα18 transcripts, but are devoid of surface expression of the invariant Vα14 receptor, have the potential to generate mature NKT cells both in vitro and in vivo. Our findings have provided new insights into the early development of NKT cells prior to surface expression of the invariant Vα14 antigen receptor and suggest a possible alternative developmental pathway of NKT cells.
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Research Products
(25 results)
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[Journal Article] Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells.2010
Author(s)
Watarai H, Fujii SI, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Shozaki Y, Sharif J, Matsuda M, Mochiduki S, Hasegawa T, Kitahara G, Endo T, Toyoda T, Ohara O, Harigaya KI, Koseki H, Taniguchi M
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Journal Title
J Clin Invest 120
Pages: 2610-2618
Peer Reviewed
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[Journal Article] Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRα gene.2010
Author(s)
Watarai H, Rybouchkin A, Nagata Y, Hongo N, Sakata S, Sekine E, Dashtsoodol N, Tashiro T, Fujii S, Shimizu K, Mori K, Kawamoto H, Koseki H, Taniguchi M
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Journal Title
Peer Reviewed
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[Journal Article] IL-21induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses.2006
Author(s)
Harada M, Magara-Koyanagi K, Watarai H, Nagata Y, Ishii Y, Kojo S, Horiguchi S, Okamoto Y, Nakayama T, Suzuki N, Yeh WC, Akira S, Kitamura H, Ohara O, Seino K, Taniguchi M
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Journal Title
J Exp Med 203
Pages: 2929-2937
Peer Reviewed
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