Disturbance of hepatic function and overnutrition-related diseases

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18109008
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Kanazawa University
• Principal Investigator: KANEKO Shuichi Kanazawa University, 医学系, 教授 (60185923)
• Project Period (FY): 2006 – 2010
• Keywords: ゲノム / 発現制御 / 肝臓 / 栄養 / 生活習慣病

Research Abstract

肝臓は、糖・タンパク・脂質の代謝や薬物および異物の解毒を専門とする巨大な臓器である。大量の物質を血液から取り込んで代謝し、全身の臓器に代謝物を供給する。
21 世紀の最大の課題である動脈硬化、糖尿病、癌、炎症といった栄養状態が関与する症候群に、肝臓の機能破綻が大きく関与している可能性がある。
本研究は、過栄養状態における肝臓の変化を明らかにすることによって新たな肝臓病の疾病概念を確立するとともに、肝臓機能の破綻によって生じる肝代謝異常の診断および治療法開発の基盤となるべき研究を行う。

Research Products

• [Journal Article] Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients (2008)
  • Author(s): T Takamura, H Misu, N Matsuzawa-Nagata, M Sakurai, T Ota, A Shimizu, S Kurita, Y Takeshita, H Ando, M Honda, S Kaneko
  • Journal Title: Obesity 16(12) Pages: 2061-2609
  • Peer Reviewed
• [Journal Article] Comparative analysis of proteome and transcriptome in human hepatocellular carcinoma using 2D-DIGE and SAGE (2008)
  • Author(s): H Minagawa, T Yamashita, M Honda, Y Tabuse, K Kamijo, A Tsugita and S Kaneko.
  • Journal Title: Protein J 27(7-8) Pages: 409-419
  • Peer Reviewed
• [Journal Article] Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet (2007)
  • Author(s): N Matsuzawa, T Takamura, S Kurita, H Misu, T Ota, H Ando, M Yokoyama, M Honda, Y Zen, Y Nakanuma, K Miyamoto and S Kaneko
  • Journal Title: Hepatology 46(5) Pages: 1392-1403
  • Peer Reviewed
• [Journal Article] Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes (2007)
  • Author(s): H Misu, T Takamura, N Matsuzawa, A Shimizu, T Ota, M Sakurai, H Ando, K Arai, T Yamashita, M Honda, T Yamashita and S Kaneko.
  • Journal Title: Diabetologia 50(2) Pages: 268-277
  • Peer Reviewed
• [Journal Article] Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis (2007)
  • Author(s): T Ota, T Takamura, S Kurita, N Matsuzawa, Y Kita, M Uno, H Akahori, H Misu, M Sakurai, Y Zen, Y Nakanuma and S Kaneko
  • Journal Title: Gastroenterology 132(1) Pages: 282-293
  • Peer Reviewed
• [Remarks]
  • URL: http://www.m-kanazawa.jp