Exploration and Identification of Biomarkers of Multiple SclerosisWhich is Relevant for Management and Research of MS

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18109009
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: YAMAMURA Takashi National Center of Neurology and Psychiatry, 神経センター神経研究所・疾病研究第六部, 部長 (90231670)
• Project Period (FY): 2006 – 2010
• Keywords: 多発性硬化症 / NK細胞 / バイオマーカー / CD11c

Research Abstract

多発性硬化症(MS)患者の疾患活動性を評価する指標として、NK 細胞のCD11c 分子発現レベルに着目し、その臨床的意義を明らかにする。また、MS 病態と関連するバイオマーカーをNK 細胞発現分子の中から同定し、臨床で利用できるようにすることを目標としている。

Research Products

• [Journal Article] Human Th17 cells are identified asbearing CCR2+CCR5- phenotype (2007)
  • Author(s): Sato, W., T. Aranami and T. Yamamura
  • Journal Title: J.Immunol 178 Pages: 7525-7529
  • Peer Reviewed
• [Journal Article] T cellgene expression profiling identifies distinctsubgroups of Japanese multiple sclerosispatients (2006)
  • Author(s): Satoh, J., M. Nakanishi, F. Koike, H. Onoue, T. Aranami, T. Yamamoto, M. Kawai, S.Kikuchi, K. Nomura, K. Yokoyama, K. Ota, T. Saito, M. Ohta, S. Miyake, T. Kanda, T.Fukazawa and T. Yamamura
  • Journal Title: J. Neuroimmunol 174 Pages: 108-118
  • Peer Reviewed
• [Journal Article] Differential expression of CD11c byperipheral blood NK cells reflects temporalactivity of multiple sclerosis (2006)
  • Author(s): Aranami, T., S. Miyake and T. Yamamura
  • Journal Title: J. Immunol 177 Pages: 5659-5667
  • Peer Reviewed
• [Presentation] Orphan nuclear receptorNR4A2 and inflammatory cascade ofMS/EAE (2008)
  • Author(s): Yamamura, T
  • Organizer: IXthInternational Congress ofNeuroimmunology
  • Place of Presentation: Fort Worth, Texas, USA
  • Year and Date: 2008-10-29
• [Presentation] 多発性硬化症の病態解析から治療標的の同定へ (2008)
  • Author(s): 山村隆
  • Organizer: 日本臨床免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-18
• [Presentation] 多発性硬化症の分子病態と治療標的 (2008)
  • Author(s): 山村隆
  • Organizer: 日本臨床分子医学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-07-24
• [Presentation] 免疫疾患としての多発性硬化症 (2008)
  • Author(s): 山村隆
  • Organizer: 日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] 特別講演 V. 免疫制御システムと神経免疫疾患 (2008)
  • Author(s): 山村隆
  • Organizer: 第20回日本神経免疫学会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] Regulatory networks inthe immune system (2007)
  • Author(s): Yamamura, T
  • Organizer: International Symposium on MultipleSclerosis-advances in basic researchand immunotherapy- Im Horsaalzentrumdes Katholischen Klinikums Bochum
  • Place of Presentation: Bochum, Germany
  • Year and Date: 2007-12-08
• [Presentation] The role of IL-5producing NK and NKT cells in the humanimmune homeostasis (2007)
  • Author(s): Yamamura, T
  • Organizer: Symposium 8. Human immunity and immuneintervention. The 35^<th> Annual Meetingof the Japanese Society of Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-11-21
• [Presentation] Microarray analysisidentifies distinct subgroups ofJapanese multiple sclerosis patients.Panel Session 5 Advancing MicroarrayTechnology in GeriatricPsychoneuropharmacology (2007)
  • Author(s): Yamamura, T
  • Organizer: 7^<th> Internatonal College of GeriatricPsychoneuropharmacology(ICGP)
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-01
• [Presentation] 多発性硬化症の臨床免疫学 (2007)
  • Author(s): 山村隆
  • Organizer: Plenary lecture 3.第35回日本臨床免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-20
• [Presentation] Regulation ofAutoimmune Diseases by Invariant Tcells(NKT cells and MAIT cells) (2007)
  • Author(s): Yamamura, T
  • Organizer: The 20th NAITO Conferenceon InnateImmunity in Medicine andBiology[III]
  • Place of Presentation: Shonan Village Center
  • Year and Date: 2007-10-12
• [Presentation] Regulatory roles ofinvariant T cells in autoimmuneinflammation (2007)
  • Author(s): Yamamura, T
  • Organizer: MainSymposium. Mechanisms of inflammatorydiseases. 13^<th> International Congressof Immunology
  • Place of Presentation: Rio, Brazil
  • Year and Date: 2007-08-22
• [Presentation] NK cells and multiplesclerosis : Do the innate cells mirror temporal disease activity? (2007)
  • Author(s): Yamamura, T
  • Organizer: Pecs -Tubingen NeuroimmunologyDays 2007
  • Place of Presentation: Pecs
  • Year and Date: 2007-04-13
• [Book] Results Probl Cell Differ (2009)
  • Author(s): Sakuishi K, Miyake S, Yamamura T
  • Publisher: Role of NK Cells and Invariant NKTCells in Multiple Sclerosis
• [Book] unraveling the complexity (2007)
  • Author(s): Miyake S, Yamamura T
  • Total Pages: 314(251-67)
  • Publisher: NKT cells and autoimmune diseases