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2010 Fiscal Year Final Research Report

Exploration and Identification of Biomarkers of Multiple Sclerosis which is relevant for Management and Research of MS

Research Project

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Project/Area Number 18109009
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

YAMAMURA Takashi  National Center of Neurology and Psychiatry, 神経研究所免疫研究部, 部長 (90231670)

Co-Investigator(Kenkyū-buntansha) ARANAMI Toshimasa  独)国立精神・神経医療研究センター, 神経研究所免疫研究部, 室長 (60435724)
MIYAKE Sachiko  独)国立精神・神経医療研究センター, 研究所免疫研究部, 室長 (50266045)
Project Period (FY) 2006 – 2010
Keywords神経科学 / 脳神経疾患 / マイクロアレイ / 免疫学 / 薬剤反応性
Research Abstract

By analyzing blood and cerebrospinal fluid (CSF) samples with DNA microarray and flow cytometry, we have attempted to identify biomarkers useful for diagnosis and treatment of multiple sclerosis (MS) and neuromyelitis optica (NMO). We successfully identified a T cell subset expanded in the CSF of MS and a B cell subset expanded in the blood of NMO. These results offer a novel method to make correct diagnosis and lead to development of new therapies targeting these expanded populations.

  • Research Products

    (16 results)

All 2011 2009 2008 2007 2006 Other

All Journal Article (11 results) Presentation (1 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica.2011

    • Author(s)
      Chihara N., T.Aranami, W.Sato Y.Miyazaki S.Miyake, T.Okamoto, M.Ogawa T.Toda, T.Yamamura
    • Journal Title

      PNAS 108

      Pages: 3701-3706

  • [Journal Article] Influenza A infection in suckling mice expands a population of NKT cells that protects mice as adults from airway hyperreactivity.2011

    • Author(s)
      Chang Y-J., H.Y.Kim, L.A.Albacker, et al.
    • Journal Title

      J.Clin.Invest. 121

      Pages: 57-69

  • [Journal Article] Suppression of experimental autoimmune encephalomyelitis by Ghrelin.2009

    • Author(s)
      Theil M.M., S.Miyake, M.Mizuno, C.Tomi, J.L.Croxford, H.Hosoda, J.Theil, S.von Hoersten, H.Yokote, A.Chiba, Y.Lin, S.Oki, T.Akamizu, K.Kangawa, T.Yamamura
    • Journal Title

      J.Immunol. 183

      Pages: 2859-2866

  • [Journal Article] Molecular network of the comprehensive multiple sclerosis brain lesion proteome.2009

    • Author(s)
      Satoh J.I., H.Tabunoki, T.Yamamura
    • Journal Title

      Mult.Scler. 15

      Pages: 531-541

  • [Journal Article] Molecular network analysis of T-cell transcriptome suggests aberrant regulation of gene expression by NF-κB as a biomarker for relapse of multiple sclerosis.2008

    • Author(s)
      Satoh J-i., T.Misawa, H.Tabunoki, T.Yamamura
    • Journal Title

      Dis Markers 25

      Pages: 27-35

  • [Journal Article] Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines.2008

    • Author(s)
      Doi Y., S.Oki, T.Ozawa, H.Hohjoh, S.Miyake, T.Yamamura
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 8381-8386

  • [Journal Article] Th17 cells and autoimmune encephalomyelitis (EAE/MS).2008

    • Author(s)
      Aranami T., T.Yamamura
    • Journal Title

      Allergol.Int. 57

      Pages: 115-120

  • [Journal Article] Cutting Edge.Human Th17 cells are identified as bearing CCR2+CCR5-phenotype.2007

    • Author(s)
      Sato W., T.Aranami, T.Yamamura
    • Journal Title

      J.Immunol. 178

      Pages: 7525-7529

  • [Journal Article] Understanding the behavior of invariant NKT cells in autoimmune diseases.2007

    • Author(s)
      Yamamura T., K.Sakuishi, Zs.Illes, S.Miyake
    • Journal Title

      J.Neuroimmunol. 191

      Pages: 8-15

  • [Journal Article] Differential expression of CD11c by peripheral blood NK cells reflects temporal activity of multiple sclerosis.2006

    • Author(s)
      Aranami T., S.Miyake, T.Yamamura
    • Journal Title

      J.Immunol. 177

      Pages: 5659-5667

  • [Journal Article] Increase of Ki-67+natural killer cells in multiple sclerosis patients treated with interferon-b combined with low-dose oral steroids.

    • Author(s)
      Sanvito L., A.Tomita, N.Chihara, T.Okamoto, M.Ogawa, B.Gran, T.Aranami, T.Yamamura
    • Journal Title

      J.Neuroimmunol. (in press)

  • [Presentation] Orphan nuclear receptor NR4A2 and inflammatory cascade of MS/EAE. Plenary Session. Effector Mechanisms2008

    • Author(s)
      Yamamura T
    • Organizer
      IXth International Congress of Neuroimmunology, Sheraton Fort Worth Hotel and Spa, Fort Worth
    • Place of Presentation
      Texas, USA
    • Year and Date
      2008-10-29
  • [Book] The Immune System Series "Results and Problems in Cell Differentiation"(Role of NK cells and NKT cells in multiple sclerosis. Molecular Basis of Multiple Sclerosis)(Roland Martin, and Andreas Lutterotti, ed 51 査読あり)2009

    • Author(s)
      Sakuishi K., S.Miyake, Yamamura T.
    • Total Pages
      127-147
    • Publisher
      Springer-Verlag, Heidelberg
  • [Book] Immune Regulation and Immunotherapy in Autoimmune Disease.(Editor Jingwu Zhang)(Invariant NKT cells and immune regulation in multiple sclerosis 査読なし)2007

    • Author(s)
      Yamamura T
    • Total Pages
      139-151
    • Publisher
      Springer
  • [Remarks] ホームページ等

    • URL

      http://www.ncnp.go.jp/nin/guide/r_men/yamamura.html

  • [Remarks]

    • URL

      http://www.ncnp.go.jp/nin/guide/r_men/yamamura-e.html

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Published: 2012-01-26   Modified: 2016-04-21  

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