2010 Fiscal Year Final Research Report
Exploration and Identification of Biomarkers of Multiple Sclerosis which is relevant for Management and Research of MS
| Project/Area Number |
18109009
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
YAMAMURA Takashi National Center of Neurology and Psychiatry, 神経研究所免疫研究部, 部長 (90231670)
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| Co-Investigator(Kenkyū-buntansha) |
ARANAMI Toshimasa 独)国立精神・神経医療研究センター, 神経研究所免疫研究部, 室長 (60435724)
MIYAKE Sachiko 独)国立精神・神経医療研究センター, 研究所免疫研究部, 室長 (50266045)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 神経科学 / 脳神経疾患 / マイクロアレイ / 免疫学 / 薬剤反応性 |
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| Research Abstract |
By analyzing blood and cerebrospinal fluid (CSF) samples with DNA microarray and flow cytometry, we have attempted to identify biomarkers useful for diagnosis and treatment of multiple sclerosis (MS) and neuromyelitis optica (NMO). We successfully identified a T cell subset expanded in the CSF of MS and a B cell subset expanded in the blood of NMO. These results offer a novel method to make correct diagnosis and lead to development of new therapies targeting these expanded populations.
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Research Products
(16 results)
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[Journal Article] Suppression of experimental autoimmune encephalomyelitis by Ghrelin.2009
Author(s)
Theil M.M., S.Miyake, M.Mizuno, C.Tomi, J.L.Croxford, H.Hosoda, J.Theil, S.von Hoersten, H.Yokote, A.Chiba, Y.Lin, S.Oki, T.Akamizu, K.Kangawa, T.Yamamura
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Journal Title
J.Immunol. 183
Pages: 2859-2866
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