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2008 Fiscal Year Self-evaluation Report

Taste Signaling Mechanisms for the Regulation of Food Intake : Approaches to Establishment for Taste Health Science

Research Project

  • PDF
Project/Area Number 18109013
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionKyushu University

Principal Investigator

NINOMIYA Yuzo  Kyushu University, 大学院・歯学研究院, 教授 (50076048)

Project Period (FY) 2006 – 2010
Keywords味覚 / 甘味受容体 / 遺伝子多型 / 肥満 / ホルモン
Research Abstract

味覚は消化管の入り口で、食物情報をいち早く中枢に伝え、消化吸収を円滑にし、エネルギーやミネラルバランスの維持に働く健康維持に不可欠な感覚であると考えられている。甘味・塩味物質の過剰摂取は生活習慣病の起因となりえる。そこで本研究は、食嗜好に関与する甘味・うま味・塩味に焦点をあて、(1) 味細胞における受容と神経情報伝達、(2) 修飾物質による感受性調節、(3) 肥満・非肥満者の味覚受容・栄養吸収のホルモンによる修飾、(4) 関連遺伝子の多型性と感受性変異の連関、について解析し味覚の食を通じた健康への寄与を探求する。

  • Research Products

    (8 results)

All 2009 2008 2007 2006 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion2009

    • Author(s)
      Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, Lohse MJ, Shigemura N, Ninomiya Y, Kojima I.
    • Journal Title

      PLoS ONE 4 : e5106

    • Peer Reviewed
  • [Journal Article] Diurnal variation of human sweet taste recpgnition thresholds is correlated with plasma leptin levels2008

    • Author(s)
      Nakamura Y, Sanematsu K, Ohta R, Shirosaki S, Koyano K, Nonaka K, Shigemura N, Ninomiya Y.
    • Journal Title

      Diabetes 57

      Pages: 2661-2665

    • Peer Reviewed
  • [Journal Article] T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.2007

    • Author(s)
      Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP.
    • Journal Title

      Proc Natl Acad Sci USA. 104

      Pages: 15075-15080

    • Peer Reviewed
  • [Journal Article] Recovery of two independent sweet taste systems during regeneration of the mouse chorda tympani nerve after nerve crush2007

    • Author(s)
      Yasumatsu K, Kusuhara Y, Shigemura N, Ninomiya Y.
    • Journal Title

      Eur J Neurosci 26

      Pages: 1521-1529

    • Peer Reviewed
  • [Journal Article] Taste responsiveness of fungiform taste cells with action potentials2006

    • Author(s)
      Yoshida R, Shigemura N, Sanematsu K, Yasumatsu K, Ishizuka S, Ninomiya Y.
    • Journal Title

      J Neurophysiol 96

      Pages: 3088-3095

    • Peer Reviewed
  • [Presentation] 口腔・消化管の甘味センサーと食調節2009

    • Author(s)
      二ノ宮,裕三
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20090316-18
  • [Presentation] Modulation and transmission of sweet taste information for energy homeostasis2008

    • Author(s)
      Ninomiya Y.
    • Organizer
      The 15^<th> ISOT
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      20080721-26
  • [Remarks]

    • URL

      http://www.dent.kyushu-u.ac.jp/sosiki/a06/index.html

URL: 

Published: 2010-06-11   Modified: 2016-04-21  

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