2010 Fiscal Year Final Research Report
Taste Signaling Mechanisms for the Regulation of Food Intake: Approaches to Establishment for Taste Health Science
| Project/Area Number |
18109013
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
NINOMIYA Yuzo Kyushu University, 大学院・歯学研究院, 教授 (50076048)
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| Co-Investigator(Kenkyū-buntansha) |
SHIGEMURA Noriatsu 九州大学, 大学院・歯学研究院, 准教授 (40336079)
YOSHIDA Ryusuke 九州大学, 大学院・歯学研究院, 助教 (60380705)
SANEMATSU KEISUKE 九州大学, 大学院・歯学研究院, 助教 (70567502)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 味覚 / 甘味受容体 / 遺伝子多型 / 肥満 / ホルモン |
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| Research Abstract |
Reception and modulation of taste signals and their roles in the regulation of food intake are investigated by examining taste cell, nerve and behavioral responses to various taste compounds. The results showed that sweet taste signal is initiated from a particular group of taste cells expressing T1r2/T1r3 sweet receptors and is transmitted to its corresponding group of nerve fibers through ATP release. Sweet taste sensitivity is inhibited by leptin, a satiety hormone, of which plasma level has a diurnal variation. Sweet taste thresholds also show diurnal variation that is parallel with that of plasma leptin levels. This synchronization, however, is not evident in obese subjects. Analyses on single nucleotide polymorphisms of umami receptor genes indicate existence of multiple receptors in umami perception in humans. These results provide new findings in the taste receptor and transduction mechanisms and new insights for potential roles of peripheral taste signal in the control for food intake, of which abnormality may possibly lead to the obesity.
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[Journal Article] Endocannabinoids selectively enhance sweet taste.2010
Author(s)
Yoshida R., Ohkuri T., Jyotaki M., Yasuo T., Horio N., Yasumatsu K., Sanematsu K., Shigemura N., Yamamoto T., Margolskee RF., Ninomiya Y.
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Journal Title
Proc. Natl. Acad. Sci. USA 107:(2)
Pages: 935-939
Peer Reviewed
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[Journal Article] Discrimi-nation of taste qualities among mouse fungiform taste bud cells.2009
Author(s)
Yoshida R., Miyauchi A., Yasuo T., Jyotaki M., Murata Y., Yasumatsu K., Shigemura N., Yanagawa Y., Obata K., Ueno H., Margolskee RF., Ninomiya Y.
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Journal Title
J Physiol 587:(18)
Pages: 4425-4439
Peer Reviewed
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[Journal Article] Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin.2008
Author(s)
Shigemura N., Nakao K., Yasuo T., Murata Y., Yasumatsu K., Nakashima A., Katsukawa H., Sako N., Ninomiya Y.
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Journal Title
Biochem Biophys Res Commun. 367:(2)
Pages: 356-363
Peer Reviewed
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