• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2008 Fiscal Year Final Research Report

Regulation mechanism of information transmission at single central synapses

Research Project

  • PDF
Project/Area Number 18200023
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionKyoto University

Principal Investigator

HIRANO Tomoo  Kyoto University, 大学院・理学研究科, 教授 (50181178)

Project Period (FY) 2006 – 2008
Keywordsシナプス / 海馬 / 小脳 / 錐体細胞 / プルキンエ細胞 / スパイン / グルタミン酸
Research Abstract

哺乳類中枢神経系内シナプスの機能と形態の性質およびそれらの相関を単一シナプスレベルで解明することをめざし、海馬錐体細胞と小脳プルキンエ細胞上に形成されるグルタミン酸作動性興奮性ミナプスを比較研究した。海馬のシナプスにおいては、シナプス応答の強さとシナプス後部スパインの大きさが相関し、小脳シナプスにおいてはシナプス前膨大とシナプス後スパインの大きさが相関するなど、両シナプスの違いが明らかになった。

  • Research Products

    (12 results)

All 2009 2008 2007 2006

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (7 results)

  • [Journal Article] Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity2009

    • Author(s)
      Kitagawa, Y., Hirano, T., Kawaguchi, S.
    • Journal Title

      Mol.Syst.Biol. 5, 280

      Pages: 1-16

    • Peer Reviewed
  • [Journal Article] Postsynaptic glutamate receptor δ family contributes to presynaptic terminal differentiation and establishment of synaptic transmission2009

    • Author(s)
      Kuroyanagi, T., Yokoyama, M., Hirano. T.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106

      Pages: 4912-4916

    • Peer Reviewed
  • [Journal Article] mGluRl-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron2008

    • Author(s)
      Y., Kawaguchi, S., Hirano, T.
    • Journal Title

      Eur.J.Neurosci. 27

      Pages: 884-896

    • Peer Reviewed
  • [Journal Article] Sustained GABARAP structural change underlies long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron2007

    • Author(s)
      Kawaguchi, S., Hirano T.
    • Journal Title

      J.Neurosci 27

      Pages: 6788-6799

    • Peer Reviewed
  • [Journal Article] Persistent activation of protein kinase Cα is not necessary for expression of cerebellar long-term depression2007

    • Author(s)
      Tsuruno, S., Hirano, T.
    • Journal Title

      Mol.Cell Neurosci 35

      Pages: 38-48

    • Peer Reviewed
  • [Presentation] Correlations between function and morphology of single synapses on hippocampal pyramidal neurons and cerebellar Purkinje neurons are different2009

    • Author(s)
      Miyawaki, H., Hirano, T.
    • Organizer
      39th Annual Meeting of the Society for Neuroscience, Chicago
    • Place of Presentation
      McCormick Place Convention Center
    • Year and Date
      2009-10-21
  • [Presentation] Correlations between function and morphology of single synapses on hippocampal pyramidal neurons and cerebellar Purkinje neurons are different2009

    • Author(s)
      Miyawaki, H., Hirano, T.
    • Organizer
      32nd annual meeting of the Japan Neuroscience Society, Nagoya
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-17
  • [Presentation] Roles of glutamate receptor δ family in synapse formation2009

    • Author(s)
      Hirano, T.
    • Organizer
      Symposium "Novel aspects of the function of ionotropic & metabotropic glutamate receptors" in the 32nd annual meeting of the Japan Neuroscience Society, Nagoya
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-16
  • [Presentation] 小脳プルキンエ細胞における個々のシナプスでのEPSCの特性2008

    • Author(s)
      宮脇寛行, 平野丈夫
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京、東京国際フォーラム
    • Year and Date
      2008-07-11
  • [Presentation] Regulation of synaptic transmission and motor learning2008

    • Author(s)
      Hirano. T.
    • Organizer
      International symposium on hierarchy and holism : Bridging across different hierarchies in natural sciences. Okazaki
    • Place of Presentation
      自然科学研究機構
    • Year and Date
      2008-02-22
  • [Presentation] Critical role of GABARAP in long-term potentiation at inhibitory synapses on a Purkinje neuron2007

    • Author(s)
      Kawaguchi, S., Hirano, T.
    • Organizer
      37th Annual Meeting of the Society for Neuroscience, San Diego
    • Place of Presentation
      San Diego Convention Center
    • Year and Date
      2007-11-06
  • [Presentation] Regulatory mechanism of inhibitory synaptic transmission in the cerebellum2006

    • Author(s)
      Kawaguchi, S., Hirano. T.
    • Organizer
      Symposium "Regulatory mechanism of GABAergic synaptic transmission" in the 29th annual meeting of the Japan Neuroscience Society, Kyoto
    • Place of Presentation
      京都国際会館
    • Year and Date
      2006-07-21

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi