A study about lungs microstructure analysis by the super high-definition CT and the diagnosis application

2008 Fiscal Year Final Research Report

• Project/Area Number: 18200031
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The University of Tokushima
• Principal Investigator: NIKI Noboru The University of Tokushima, 大学院・ソシオテクノサイエンス研究部, 教授 (80116847)
• Co-Investigator(Kenkyū-buntansha): KAWATA Yoshiki 徳島大学, 大学院・ソシオテクノサイエンス研究部, 准教授 (70274264) ; ITOH Harumi 福井大学, 特任教授 (40026943) ; KOSAKA Nobuyuki 福井大学, 医学部, 助教 (60397247) ; KAKINUMA Ryutaro 国立がんセンターがん予防, 検診研究センター検診技術開発部, 室長 (90415521)
• Project Period (FY): 2006 – 2008
• Keywords: 3次元肺ミクロ構造解析 / デジタル肺ライブラリィー / 3次元肺ミクロ形態学 / マイクロCT / 放射光CT(SPring8) / 肺2次小葉

Research Abstract

次世代の画像診断に向けてミクロ形態を観察して疾患の極初期段階を診断することは極めて重要な課題である. 特に, 肺の正常形態, 極早期の疾患病態のミクロレベルでの画像化とその定量的解析の実現は, 未知分野である肺ミクロ形態・病態の画像診断学を拓き, 次世代の胸部画像診断への貢献が期待できる.
本研究では人体のミクロ形態・病態を超高精細拡大CT と高輝度な放射光CT によって画像化して定量的解析する基盤技術の研究開発を行い, 形態・病態の統計数理解析と根拠に基づく肺ミクロ画像診断の構築を目指した. 本研究で開発した基盤技術を実際の人体切除肺標本と人体肺に適用してその有用性を示した.

Research Products

• [Journal Article] CT像からのPoint Spread Function測定法 (2009)
  • Author(s): 河田佳樹, 仁木登
  • Journal Title: 画像ラボ Vol.20, No.1 Pages: 21-24
• [Journal Article] Bronchial Wall Regions Extraction Algorithm using Multi Slice CT Images (2009)
  • Author(s): K. Akashi, S. Saita, M. Kubo, Y. Kawata, N. Niki, Y. Nakano, H. Nishitani, H. Ohmatsu, K. Eguchi, M. Kaneko, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging Vol.7258 Pages: 72582J-1-8
  • Peer Reviewed
• [Journal Article] Measurement of spatial and density resolutions in x-ray nano computed tomography (2009)
  • Author(s): Y. Kawata, K. Kageyama, Y. Nakaya, N. Niki, H. Ohmatsu, K. Eguchi, M. Kaneko, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging Vol.7258 Pages: 725809-1-8
  • Peer Reviewed
• [Journal Article] Growth-pattern classification of pulmonary nodules based on variation of CT number histogram and its potential usefulness in nodule differentiation (2009)
  • Author(s): Y. Kawata, A. Kawamata, N. Niki, H. Ohmatsu, R. Kakinuma, K. Eguchi, M. Kaneko, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging Vol.7260 Pages: 726010-1-10
  • Peer Reviewed
• [Journal Article] 肺がんCT検診の業務支援システム (2008)
  • Author(s): 石垣陸太, 花井耕造, 鈴木雅裕, 河田佳樹, 仁木登, 江口研二, 柿沼龍太郎, 森山紀之
  • Journal Title: 電子情報通信学会論文誌 Vol.J91-D, No.10 Pages: 2550-2558
  • Peer Reviewed
• [Journal Article] 招待論文肺がんCT検診のコンピュータ支援診断の展開 (2008)
  • Author(s): 仁木登
  • Journal Title: 電子情報通信学会論文誌 Vol.J91-D, No.7 Pages: 1715-1729
  • Peer Reviewed
• [Journal Article] CT像からのPSF測定法 (2008)
  • Author(s): 河田佳樹, 中屋良宏, 仁木登, 大松広伸, 江口研二, 金子昌弘, 森山紀之
  • Journal Title: 電子情報通信学会論文誌 Vol.J91-D, No.7 Pages: 1766-1777
  • Peer Reviewed
• [Journal Article] DICOM画像の個人情報保護のための匿名化システム (2008)
  • Author(s): 鈴木秀宣, 天野雅史, 財田伸介, 久保満, 河田佳樹, 仁木登, 上野淳二, 西谷弘
  • Journal Title: 電子情報通信学会論文誌 Vol.J91-D, No.6 Pages: 1656-1622
  • Peer Reviewed
• [Journal Article] Performance Evaluation of 4 Measuring Methods of Ground-Glass Opacities for Predicting the 5-Year Relapse-Free Survival of Patients With Peripheral Nonsmall Cell Lung Cancer (2008)
  • Author(s): R. Kakinuma, K. Kodama, K. Yamada, A. Yokoyama, S. Adachi, K. Mori, Y. Fukuda, K. Kuriyama, J. Oda, M. Noguchi, Y. Matsuno, T. Yokose, H. Ohmatsu, Y. Nishiwaki
  • Journal Title: A Multicenter Study, Journal of Computer Assisted Tomography Vol.32, No.5 Pages: 792-797
  • Peer Reviewed
• [Journal Article] Low-dose CT screening for lung cancer with automatic exposure control : phantom study (2008)
  • Author(s): S. Gomi, Y. Muramatsu, S. Tsukagoshi, M. Suzuki, R.Kakinuma, R.Tsuchiya, N. Moriyama
  • Journal Title: Radiological Physics and Technology Vol.1 Pages: 244-250
  • Peer Reviewed
• [Journal Article] Evaluation of whole body cancer screening using 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography (2008)
  • Author(s): T. Terauchi, T. Murano, H. Daisaki, D. Kanou, H.Shoda, R.Kakinuma, C. Hamashima, N. Moriyama, T. Kakizoe
  • Journal Title: a preliminary report., Annuals of Nuclear Medicine Vol.22 Pages: 379-385
  • Peer Reviewed
• [Journal Article] 低線量ヘリカルCTによる肺がん検診の実際 (2008)
  • Author(s): 柿沼龍太郎, 金子昌弘, 大松広伸, 江口研二, 森山紀之
  • Journal Title: 呼吸と循環 Vol.56, No.5 Pages: 457-463
  • Peer Reviewed
• [Journal Article] 肺がんCT検診のコンピュータ支援診断 (2008)
  • Author(s): 仁木登
  • Journal Title: 新医療 Vol.35, No.10 Pages: 106-109
  • Peer Reviewed
• [Journal Article] 医用画像論文特集の発行にあたって (2008)
  • Author(s): 仁木登
  • Journal Title: 電子情報通信学会論文誌 Vol.J91-D, No.7 Pages: 1693-1694
  • Peer Reviewed
• [Journal Article] 早期がん診断・治療を対象にしたイメージング技術 (2008)
  • Author(s): 仁木登
  • Journal Title: OPTICS/ELECTRONICS Vol.30, No.6 Pages: 603-605
  • Peer Reviewed
• [Journal Article] 肺がんCT検診のコンピュータ支援診断 (2008)
  • Author(s): 仁木登
  • Journal Title: 呼吸と循環 Vol.56, No.5 Pages: 477-484
  • Peer Reviewed
• [Journal Article] CADによる肺がん以外の胸郭病変の診断支援 (2008)
  • Author(s): 中野恭幸, 財田伸介, 仁木登
  • Journal Title: 呼吸と循環 Vol.56, No.5 Pages: 485-490
  • Peer Reviewed
• [Journal Article] Invited talk Multi-organ, multi-disease CAD system in thoracic CT (2008)
  • Author(s): N. Niki
  • Journal Title: International Journal of Computer Assisted Radiology and Surgery Suppl.1, S231
  • Peer Reviewed
• [Journal Article] Classifying pulmonary nodules using dynamic enhanced CT images based on CT number histogram (2008)
  • Author(s): K. Minami, Y. Kawata, N. Niki, H. Ohmatsu, K. Mori, K. Yamada, M. Kaneko, K. Eguchi, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging(Cum Laude Poster Award 受賞) Vol.6915 Pages: 69152P-1-9
  • Peer Reviewed
• [Journal Article] Measurement of three-dimensional point spread functions in multidetector-row CT (2008)
  • Author(s): Y. Kawata, Y. Nakaya, N. Niki, H. Ohmatsu, K. Eguchi, M. Kaneko, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging Vol.6913 Pages: 691310-1-8
  • Peer Reviewed
• [Journal Article] Algorithm of pulmonary emphysema extraction using thoracic 3-D CT images (2008)
  • Author(s): S. Saita, M. Kubo, Y. Kawata, N. Niki, Y. Nakano, H. Ohmatsu, K. Tominaga, K. Eguchi, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging Vol.6915 Pages: 69152L-1-8
  • Peer Reviewed
• [Journal Article] Database construction for small lung nodule using high-resolution three-dimension CT image (2008)
  • Author(s): Y. Kozaki, Y. Kawata, N. Niki, H. Ohmatsu, M. Kusumoto, R. Kakinuma, K. Eguchi, M. Kaneko, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging Vol.6919 Pages: 691913-1-8
  • Peer Reviewed
• [Journal Article] Computer-aided diagnosis workstation and network system for chest diagnosis based on multislice CT images (2008)
  • Author(s): H. Satoh, N. Niki, K. Eguchi, N. Moriyama, H. Ohmatsu, H. Masuda, S. Machida
  • Journal Title: Proc. SPIE Medical Imaging(Cum Laude Poster Award 受賞) Vol.6919 Pages: 691916-1-11
  • Peer Reviewed
• [Journal Article] SAKURA-viewer : Intelligent order history viewer based on two-viewpoint architecture (2007)
  • Author(s): S. Toyota, N. Niki, H. Nishitani
  • Journal Title: IEEE Trans. Information Technology in Biomedicine Vol.11, No.2 Pages: 141-152
  • Peer Reviewed
• [Journal Article] 胸部CT検診のコンピュータ支援診断 (2007)
  • Author(s): 仁木登
  • Journal Title: 日本放射線技術学会雑誌 Vol.63, No.12 Pages: 1396-1403
  • Peer Reviewed
• [Journal Article] 画像診断・治療の変革 (2007)
  • Author(s): 仁木登
  • Journal Title: NLだより No.357
  • Peer Reviewed
• [Journal Article] 医用画像の研究最前線 (2007)
  • Author(s): 仁木登, 藤田広志
  • Journal Title: 電子情報通信学会論文誌情報・システムソサイエティ誌 Vol.12, No.1 Pages: 6-13
  • Peer Reviewed
• [Journal Article] 呼吸器感染症の画像診断に必要とされる肺既存構造 (2007)
  • Author(s): 伊藤春海
  • Journal Title: 化学療法の領域 Vol.23, No.1 Pages: 20-29
  • Peer Reviewed
• [Journal Article] Classifying pulmonary nodules using dynamic enhanced CT images based on CT number histogram (2007)
  • Author(s): K. Minami, Y. Kawata, N. Niki, H. Ohmatsu, M. Kusumoto, R. Kakinuma, K. Eguchi, K. Mori, M. Kaneko, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging Vol.6514 Pages: 65143B-1-11
  • Peer Reviewed
• [Journal Article] Automated anatomical labeling algorithm of bronchial branches based on multi-slice CT images (2007)
  • Author(s): J. Kawai, S. Saita, M. Kubo, Y. Kawata, N. Niki, Y. Nakano, H. Nishitani, H. Ohmatsu, K. Eguchi, M. Kaneko, M. Kusumoto, R. Kakinuma, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging Vol.6514 Pages: 65143S-1-8
  • Peer Reviewed
• [Journal Article] Extracting alveolar structure of human lung tissue specimens based on surface skeleton representation from 3-D micro-CT images (2007)
  • Author(s): H. Ishimori, Y. Kawata, N. Niki, Y. Nakaya, H. Ohmatsu, E. Matsui, M. Fujii, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging Vol.6514 Pages: 65143O-1-9
  • Peer Reviewed
• [Journal Article] Classification algorithm of pulmonary vein and artery based on multi-slice CT image (2007)
  • Author(s): T. Yonekura, M. Matsuhiro, S. Saita, M. Kubo, Y. Kawata, N. Niki, H. Nishitani, H. Ohmatsu, R. Kakinuma, N. Moriyama
  • Journal Title: Proc. SPIE Medical Imaging Vol.6514 Pages: 65142E-1-8
  • Peer Reviewed
• [Journal Article] Computer-simulation technique for low dose computed tomographic screening (2006)
  • Author(s): K. Hanai, T. Horiuchi, J. Sekiguchi, Y. Muramatsu, R. Kakinuma, N. Moriyama, R. Tuchiya, N. Niki
  • Journal Title: Journal of Computer Assisted Tomography Vol.30, No.6 Pages: 955-961
  • Peer Reviewed
• [Journal Article] 肺末梢の気道と肺血管について (2006)
  • Author(s): 伊藤春海
  • Journal Title: 気管支学 Vol.28, No.1 Pages: 9-14
  • Peer Reviewed
• [Journal Article] 画像診断ABC : 機器の進歩とその利用(14)3. 臨床 肺がんのCT 診断-Radiologic-Anatomic-Pathologic Correlation (2006)
  • Author(s): 伊藤春海
  • Journal Title: 医薬ジャーナル Vol.42, No.6 Pages: 5-11
  • Peer Reviewed
• [Journal Article] 胸部エックス線写真CTの正常像を見直す-Radiologic-Anatomic Correlation- (2006)
  • Author(s): 伊藤春海
  • Journal Title: 肺癌 Vol.46, No.1 Pages: 49-57
  • Peer Reviewed
• [Journal Article] Invited talk A multi-organ multi-disease CAD using chest 3D CT images (2006)
  • Author(s): N. Niki
  • Journal Title: International Journal of Computer Assisted Radiology and Surgery Vol.1 Pages: 345-346
  • Peer Reviewed
• [Journal Article] Visualization and quantitative analysis of alveoli structure of human lung tissue specimens based on micro 3-D CT images (2006)
  • Author(s): H. Ishimori, Y. Kawata, N. Niki, Y. Nakaya, H. Ohmatsu, M. Fujii, E. Matsui, N. Moriyama
  • Journal Title: RSNA Scientific Assembly and Annual Meeting program Pages: 782
  • Peer Reviewed
• [Journal Article] CT number histogram-based classification of peripheral lung adenocarcinomas of thin-section CT images : Correlation with histlogic prognostic factors (2006)
  • Author(s): Y. Kawata, K. Minami, N. Niki, H. Ohmatsu, M. Kusumoto, R. Kakinuma, K. Eguchi, M. Kaneko, N. Moriyma
  • Journal Title: 14th International Conference on Screening for Lung Cancer14th International
  • Peer Reviewed
• [Journal Article] A classification algorithm of pulmonary vein and artery based on multi-slice CT image (2006)
  • Author(s): M. Matsuhiro, T. Nishio, S. Saita, M. Kubo, Y. Kawata, N. Niki, H. Ohmatsu, K. Eguchi, M. Kaneko, M. Kusumoto, R. Kakinuma, N. Moriyama
  • Journal Title: 14th International Conference on Screening for Lung Cancer
  • Peer Reviewed
• [Presentation] 放射光CT画像による肺小葉内構造の解析 (2009)
  • Author(s): 景山浩治, 中屋良宏, 河田佳樹, 仁木登, 梅谷啓二, 伊藤春海, 森山紀之
  • Organizer: 呼吸機能イメージング研究会学術集会(71)
  • Place of Presentation: 京都
  • Year and Date: 2009-01-30
• [Presentation] 放射光CT画像を用いた肺の微細構造解析 (2008)
  • Author(s): 景山浩治, 中屋良宏, 河田佳樹, 仁木登, 梅谷啓二, 伊藤春海, 森山紀之
  • Organizer: 生体医工学シンポジウム(94-99)
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-19
• [Presentation] 放射光CT画像を用いた肺の微細構造解析 (2008)
  • Author(s): 景山浩治, 中屋良宏, 河田佳樹, 仁木登, 梅谷啓二, 伊藤春海, 森山紀之
  • Organizer: 日本医用画像工学会大会(10)
  • Place of Presentation: 東京
  • Year and Date: 2008-08-05
• [Presentation] 放射光CT画像を用いた肺の微細構造解析 (2008)
  • Author(s): 景山浩治, 中屋良宏, 河田佳樹, 仁木登, 梅谷啓二, 伊藤春海, 森山紀之
  • Organizer: 電子情報通信学会技術研究報告医用画像(49-54)
  • Place of Presentation: 愛知
  • Year and Date: 2008-05-22
• [Presentation] マルチスライスCTの3-D point spread functionの測定 (2007)
  • Author(s): 河田佳樹, 中屋良宏, 仁木登, 大松広伸, 江口研二, 金子昌弘, 森山紀之
  • Organizer: 電子情報通信学会技術研究報告医用画像(39-44)
  • Place of Presentation: 九州大学
  • Year and Date: 2007-09-20
• [Book] 呼吸器感染症の画像診断に必要とされる肺既存構造. 小葉中心性粒状影-呼吸細気管支と周囲肺実質を結ぶ構造-. 肺炎の画像診断と最新の診療(藤田次郎編著) (2008)
  • Author(s): 伊藤春海
  • Publisher: 医療者ジャーナル社
• [Book] Imaging of The Chest (Vol.1,2), Saunders (2008)
  • Author(s): H. toh and N.L. Mueller
  • Publisher: Ultrastructure of the pulmonary parenchyma