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2008 Fiscal Year Final Research Report

Development of a novel targeted single cell drug/gene delivery system

Research Project

  • PDF
Project/Area Number 18200036
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionFukuoka University

Principal Investigator

TACHIBANA Katsuro  Fukuoka University, 医学部, 教授 (40271605)

Co-Investigator(Kenkyū-buntansha) AI Hiroyuki  福岡大学, 理学部, 助教 (20330897)
Project Period (FY) 2006 – 2008
Keywords超音波エネルギー / 神経細胞 / 周波数 / 超小型超音波プローブ / 遺伝子導入
Research Abstract

本課題の目標であった超音波照射時における浮遊単細胞のリアルタイム顕微鏡観察システムを構築することができた。また、高速ビデオカメラにてマイクロバブルの挙動を観察すると同時に薬物が細胞内に流入する現象を初めてデジタル映像でとらえることができた。この顕微鏡システムを用いることで超音波の最適条件と各種のマイクロバブルの比較が可能となった。得られたデータ解析より、多種の細胞にこの技術が応用可能と考えられる。

  • Research Products

    (19 results)

All 2009 2008 2007 2006

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (7 results)

  • [Journal Article] Evaluation and comparison of three novel microbubbles : enhancement of ultrasound-induced cell death and free radicals production2009

    • Author(s)
      Hassan MA, Feril LB Jr, Suzuki K, Kudo N, Tachibana K, Kondo T
    • Journal Title

      Ultrason Sonochem 16(3)

      Pages: 372-8

    • Peer Reviewed
  • [Journal Article] Response characteristics of vibration-sensitive interneurons related to Johnston's organ in the honeybee, Apis nielllfera2009

    • Author(s)
      Hiroyuki Ai, Jurgen Rybak, Randolf Menzel, Tsunao Itoh
    • Journal Title

      J. Comp. Neurol. 515

      Pages: 145-160

    • Peer Reviewed
  • [Journal Article] 超音波感受性マイクロバブルを利用した血管壁へのドラッグデリバリー2008

    • Author(s)
      立花克郎
    • Journal Title

      血管医学 9(3)

      Pages: 287-291

    • Peer Reviewed
  • [Journal Article] Sonodynamic therapy2008

    • Author(s)
      Tachibana K, Feril LB Jr, Ikeda-Dantsuji Y
    • Journal Title

      Ultrasonics 48(4)

      Pages: 253-259

    • Peer Reviewed
  • [Journal Article] Therapeutic potential of low-intensity ultrasound (part 2) : biomolecular effects, sonotransfection, and sonoporation2008

    • Author(s)
      Feril LB Jr, Tachibana K, Ikeda-Dantsuji Y, Endo H, Harada Y, Kondo T, Ogawa R
    • Journal Title

      Journal of Medical Ultrasonics 35

      Pages: 161-167

    • Peer Reviewed
  • [Journal Article] Three-dimensional reconstruction of neural tracts and commissures in the bee brain2008

    • Author(s)
      H Ai, Y Kusakabe, T Itoh
    • Journal Title

      Comparative Biochemistry and Physiology, Part B, Biochemistry & molecular biology 151(4)

      Pages: 457

    • Peer Reviewed
  • [Journal Article] Therapeutic Potential of Low-Intensity Ultrasound(Part1) : Thermal and Sonomechanical Effects2008

    • Author(s)
      Feril Loreto, Tachibana K, Ogawa K, Irie Y
    • Journal Title

      J. Med Ultrasonics 35

      Pages: 153-160

    • Peer Reviewed
  • [Journal Article] Gene Transfer/delivery and Expression of DNA and RNA Gene Transfer/delivery and Expression of DNA and RNA Sonoporation : An Efficient Technique for the Introduction of Genes into Chick Embryos(Edited by Theodore Friedmann, John Rossi)2007

    • Author(s)
      Ohta S, Ogino Y, Suzuki K, Kamimura M, Tachibana K, and Yamada G
    • Journal Title

      Cold Spring Harbor Laboratory Press

      Pages: 711-716

    • Peer Reviewed
  • [Journal Article] Journal of Comparative Neurology, Topographic organization of sensory afferents of Johnston's organ in the honeybee brain2007

    • Journal Title

      Wiley-Liss, Inc

      Pages: 1030-1046

    • Peer Reviewed
  • [Journal Article] A novel bubble liposome and ultrasound-mediated gene transfer to ocular surface : RC-1 cells in vitro and conjunctiva in vivo2007

    • Author(s)
      Yamashita T, Sonoda S, Suzuki R, Arimura N, Tachibana K, Maruyama K, and Sakamoto T
    • Journal Title

      Experimental Eye Reserch 85(6)

      Pages: 741-748

    • Peer Reviewed
  • [Journal Article] Biomolecular Effects of Low Intensity Ultrasound : Apoptosis, Sonotransfection, and Gene Expression2007

    • Author(s)
      Feril LB Jr, Kondo T, Tabuchi Y, Ogawa R, Zhao Q-L, Nozaki T, Yoshida T, Kudo N, and Tachibana K
    • Journal Title

      Japanese Journal of Applied Physics 46(7B)

      Pages: 4435-4440

    • Peer Reviewed
  • [Journal Article] Emerging Technologies Using Ultrasound for Drug Delivery : Emerging Therapeutic Ultrasound2006

    • Author(s)
      Katsuro Tachibana
    • Journal Title

      World Scientific

      Pages: 131-166

    • Peer Reviewed
  • [Presentation] マイクロバブルと超音波治療2009

    • Author(s)
      立花克郎
    • Organizer
      第4回超音波分子診断治療研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-01-09
  • [Presentation] マイクロバブルの治療への応用2008

    • Author(s)
      立花克郎
    • Organizer
      第10回国際造影超音波シンポジウム
    • Place of Presentation
      東京医科大学病院
    • Year and Date
      2008-12-13
  • [Presentation] 神経超音波の基礎2008

    • Author(s)
      立花克郎
    • Organizer
      第11回日本栓子検出と治療学会(エンボラス学会)
    • Place of Presentation
      倉敷
    • Year and Date
      2008-11-01
  • [Presentation] U937細胞におけるドキシルと超音波併用による殺細胞効果について2008

    • Author(s)
      原田慶美、遠藤日富美、山口和記、立花克郎
    • Organizer
      第2回超音波分子診断治療研究会(第2回基礎技術研究会共催)
    • Place of Presentation
      北海道大学
    • Year and Date
      2008-08-08
  • [Presentation] 超音波・マイクロバブル・抗がん剤の併用による癌細胞株U937への殺細胞効果について2008

    • Author(s)
      原田慶美, 立花克郎, 遠藤日富美, フェリル ロリト, 山口和記
    • Organizer
      日本超音波医学会第81回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2008-05-23
  • [Presentation] Emerging Technologies Using Ultrasound for Drug Delivery2007

    • Author(s)
      立花克郎、フェリル ロリト
    • Organizer
      International Symposium on Sonochemistry and Sonoprocessing 2007 - New horizons in Sonochemistry and Sonoprocessing
    • Place of Presentation
      京都
    • Year and Date
      2007-12-08
  • [Presentation] Enhanced Gene Transfer by Echo Contrast Agents : Comparison between BR1 and BR14 in Vitro and in Vivo2007

    • Author(s)
      遠藤日富美、立花克郎、フェリル ロリト
    • Organizer
      10th Annual Meeting American Society of GENE THERAPY
    • Place of Presentation
      Seattle Washingon USA
    • Year and Date
      2007-06-02

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Published: 2010-06-10   Modified: 2016-04-21  

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