2009 Fiscal Year Final Research Report
Establishment of neuromodulation therapy with combination of electrical stimulation and Botulinum toxin
| Project/Area Number |
18200037
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
SEKI Kazunori Tohoku University, 大学院・医学系研究科, 准教授 (20206618)
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| Co-Investigator(Renkei-kenkyūsha) |
HANDA Yasunobu 東北大学, 大学院・医学系研究科, 名誉教授 (00111790)
ARAI Yoichi 東北大学, 大学院・医学系研究科, 教授 (50193058)
NAKAGAWA Haruo 東北大学, 大学院・医学系研究科, 講師 (80333574)
OGURA Takahide 東北大学, 大学院・医学系研究科, 助教 (10312688)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 電気刺激 / ボツリヌストキシン / 痙性麻痺 / 疼痛 / 神経因性膀胱 |
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| Research Abstract |
The purpose of this study is to investigate the effect of electrical stimulation (ES) and Botulinum toxin (BTX) injection as a neuromodulational therapy for treatment of three types of intractable impairments, i.e., remaining paresis after central nervous system damage, abnormal sensation and pain after stroke, and intractable overactive bladder. Combination therapy of BTX with ES provided improvement of upper limb function and long lasting spasticity reduction. Continuous application of ES to lower limb and use of EMG triggered ES showed possibility to improve gait function. Central pain was not reduced by BTX injection but pain threshold tended to normalize. Twopatients with intractable overactive bladder showed long lasting incontinence disappearance after combination therapy.
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