Physiological role(s) of the immune system and tissue-specific stem cells in the plasticity of skeletal muscles-their application to the development of sports sciences-

2009 Fiscal Year Final Research Report

• Project/Area Number: 18200042
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Hirosaki Gakuin University
• Principal Investigator: YOSHIOKA Toshitada Hirosaki Gakuin University, 社会福祉学部, 教授 (50056933)
• Co-Investigator(Kenkyū-buntansha): GOTO Katsumasa 豊橋創造大学, 保健医療学部, 教授 (70239961) ; KATAGIRI Nobuko 弘前学院大学, 看護学部, 講師 (30075428)
• Project Period (FY): 2006 – 2009
• Keywords: 骨格筋 / 可塑性 / 免疫 / 筋衛星細胞 / シグナル伝達

Research Abstract

Skeletal muscle has a large plasticity. The development of a countermeasure for the prevention of muscle atrophy, which is accompanied with the depressed contractile function, is one of important issues for the maintenance of physical activity and Quality of Life (QOL) in the preventive medicine as well as in Health and Sports Sciences. However, there is no effective countermeasure. The present study revealed that skeletal muscle plasticity could be regulated by the stimulations of both the immune systems and muscle specific stem cells, so called satellite cells. Evidences from the present study might be useful for the development of effective rehabilitations for the depressed muscle function in both atrophied and injured skeletal muscles.

Research Products

• [Journal Article] Role(s) of gravitational loading during developing period on the growth of rat soleus muscle fibers (2010)
  • Author(s): Kawano, F. 、Goto, K. 、Wang, X.D. 、Terada, M. 、Ohira, T. 、Nakai, N. 、Yoshioka, T. 、Ohira, Y.
  • Journal Title: J. Appl. Physiol. 108 Pages: 676-685
  • Peer Reviewed
• [Journal Article] 萎縮ラットヒラメ筋のデスミン発現に及ぼす熱ストレス効果 (2010)
  • Author(s): 杉浦崇夫、芝口翼、吉原利典、山元勇樹、後藤勝正、内藤久士、吉岡利忠
  • Journal Title: 体力科学 59 Pages: 167-174
  • Peer Reviewed
• [Journal Article] 筋損傷の回復を遅延・促進させる要因の再検討 (2009)
  • Author(s): 後藤勝正、大野善隆、杉浦崇夫、大平充宣、吉岡利忠
  • Journal Title: 青森県スポーツ医学研究会誌 18 Pages: 37-42
  • Peer Reviewed
• [Journal Article] Gravitational unloading inhibits the regenerative potential of atrophied soleus muscle in mice (2009)
  • Author(s): Matsuba, Y. 、Goto, K. 、Morioka, S. 、Naito, T. 、Akema, T. 、Hashimoto, N. 、Sugiura, T. 、Ohira, Y. 、Beppu, M. 、Yoshioka, T.
  • Journal Title: Acta Physiol. 196 Pages: 329-339
  • Peer Reviewed
• [Journal Article] Effects of voluntary wheel running on satellite cells in the rat plantaris muscle (2009)
  • Author(s): Kurosaka, M. 、Naito, H. 、Ogura, Y. 、Kojima, A. 、Goto, K. 、Katamoto, S.
  • Journal Title: J. Sports Sci. Med. 8 Pages: 51-57
  • Peer Reviewed
• [Journal Article] Administration of granulocyte colony-stimulating factor facilitates the regenerative process of injured mice skeletal muscle via the activation of Akt/GSK3αβsignals (2009)
  • Author(s): Naito, T. 、Goto, K. 、Morioka, S. 、Matsuba, Y. 、Akema, T. 、Sugiura, T. 、Ohira, Y. 、Beppu, M. 、Yoshioka, T.
  • Journal Title: Eur. J. Appl. Physiol. 105 Pages: 643-651
  • Peer Reviewed
• [Journal Article] Functional Overloading Facilitates the Regeneration of Injured Soleus Muscles in Mice (2008)
  • Author(s): Morioka, S. 、Goto, K. 、Kojima, A. 、Naito, T. 、Matsuba, Y. 、Akema, T. 、Fujiya, H. 、Sugiura, T. 、Ohira, Y. 、Beppu, M. 、Aoki, H. 、Yoshioka, T.
  • Journal Title: J. Physiol. Sci. 58 Pages: 397-404
  • Peer Reviewed
• [Journal Article] 長期間のアスタキサンチン摂取がサルコペニアに及ぼす影響 (2008)
  • Author(s): 芝口翼、杉浦崇夫、古本司、井上恒志郎、飯田義晴、磯山智美、内藤久士、後藤勝正、大森大二郎、吉岡利忠
  • Journal Title: 体力科学 57 Pages: 541-552
  • Peer Reviewed
• [Journal Article] Investigation of the mechanism responsible for muscle atrophy and countermeasures in microgravity environment: Role(s) of mechanical load and/or satellite cells (2008)
  • Author(s): Ohira, Y. 、Wang, X.D. 、Terada, M. 、Kawano, F. 、Matsuoka, Y. 、Higo, Y. 、Ohira, T. 、Kojima, A. 、Goto, K. 、Yoshioka, T.
  • Journal Title: Proceedings of the 1st International Space Medicine Symposium 2007 in Sapporo Pages: 91-93
• [Journal Article] Geranylgeranylaceton induces heat shock protein 72 in skeletal muscles (2007)
  • Author(s): Goto, K. 、Kojima, A. 、Morioka, S. 、Naito, T. 、Akema, T. 、Matsuba, Y. 、Fujiya, H. 、Sugiura, T. 、Ohira, Y. 、Yoshioka, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 358 Pages: 331-335
  • Peer Reviewed
• [Journal Article] Skeletal muscle hypertrophy induced by low-intensity exercise with heat-stress in healthy human subjects (2007)
  • Author(s): Goto, K., Oda, H., Morioka, S., Naito, T., Akema, T., Kato, H., Fujiya, H., Nakajima, Y, Sugiura, T., Ohira, Y., Yoshioka, T.
  • Journal Title: Jpn. J. Aerospace Environ. Med. 44 Pages: 13-18
• [Journal Article] Heat stress facilitates the regeneration of injured skeletal muscle in rats (2007)
  • Author(s): Kojima, A. 、Goto, K. 、Morioka, S. 、Naito, T. 、Akema, T. 、Fujiya, H. 、Sugiura, T. 、Ohira, Y. 、Beppu, M. 、Aoki, H. 、Yoshioka, T.
  • Journal Title: J. Orthop. Sci. 12 Pages: 74-82
  • Peer Reviewed
• [Journal Article] 宇宙環境暴露および老化による骨格筋の萎縮 (2007)
  • Author(s): 後藤勝正、大平充宣
  • Journal Title: 宇宙航空環境医学 44 Pages: 49-58
  • Peer Reviewed
• [Journal Article] Estrogen administration attenuates immobilization-induced skeletal muscle atrophy in male rats (2006)
  • Author(s): Sugiura, T. 、Ito, N. 、Goto, K, 、Naito, H. 、Yoshioka, T. 、Powers, S.K.
  • Journal Title: J、Physiol、Sci. 56 Pages: 393-399
  • Peer Reviewed
• [Presentation] Effects of loading and myostatin on the regeneration and regrowth of skeletal muscle in mice (2010)
  • Author(s): Goto, K.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡市
  • Year and Date: 20100519-20100521
• [Presentation] A physiological role of heat shock factor-related stress response in the regrowth of atrophied soleus muscle in mice (2010)
  • Author(s): Goto, K.、Ohno, Y.、Nakai, A.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim、California、USA
  • Year and Date: 20100424-20100428
• [Presentation] 温熱刺激による筋萎縮防止または萎縮からの回復に及ぼす影響とヒト骨格筋の特性に与える効果 (2009)
  • Author(s): 後藤勝正、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 第55回日本宇宙航空環境医学会大会
  • Place of Presentation: 岐阜県県民文化ホール未来会館、岐阜市
  • Year and Date: 20091112-20091114
• [Presentation] Effects of active heat shock factor 1 on skeletal muscle hypertrophy in mice (2009)
  • Author(s): Goto, K.、Ohno, Y.、Nakai, A.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: 23rd Annual Meeting of American Society for Gravitational and Space Biology
  • Place of Presentation: Raleigh、North Carolina、USA
  • Year and Date: 20091105-20091108
• [Presentation] 発育期の抗重力活動が抗重力筋の発育・発達に及ぼす影響 (2009)
  • Author(s): 後藤勝正、河野史倫、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 朱鷺メッセ、新潟市
  • Year and Date: 20090918-20090920
• [Presentation] 伸張性収縮誘発性筋損傷からの回復過程におけるAkt-mTOR系の変化 (2009)
  • Author(s): 芝口翼、杉浦崇夫、須藤みず紀、狩野豊、後藤勝正、吉岡利忠
  • Organizer: 64回日本体力医学会大会
  • Place of Presentation: 朱鷺メッセ、新潟市
  • Year and Date: 20090918-20090920
• [Presentation] Effects of Long-Term Inhibition of Myostatin on the Soleus Muscle under an Atrophic Condition (2009)
  • Author(s): Yoshioka, T.、Goto, K.、Ohno, Y.、Hashimoto, N.、Sugiura, T.、Ohira, Y.
  • Organizer: 38th European Muscle Conference
  • Place of Presentation: Lille、France
  • Year and Date: 20090912-20090916
• [Presentation] Possible role of heat shock factor 1 in loading-associated muscle hypertrophy of mice (2009)
  • Author(s): Goto, K.、Ohno, Y.、Nakai, A.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: 36th International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: 京都国際会議場、京都市
  • Year and Date: 20090727-20090801
• [Presentation] 骨格筋の可塑機構と温熱刺激 (2009)
  • Author(s): 後藤勝正、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 第17回日本運動生理学会大会
  • Place of Presentation: 東京慈恵会医科大学
  • Year and Date: 20090725-20090726
• [Presentation] 骨格筋の再生と再成長における筋衛星細胞の活性化機構に対する荷重の影響 (2009)
  • Author(s): 後藤勝正、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 第17回日本運動生理学会大会
  • Place of Presentation: 東京慈恵会医科大学
  • Year and Date: 20090725-20090726
• [Presentation] 細胞骨格からみた熱ストレスによる筋萎縮抑制効果 (2009)
  • Author(s): 杉浦崇夫、芝口翼、後藤勝正、吉原利典、内藤久士、吉岡利忠
  • Organizer: 第17回日本運動生理学会大会
  • Place of Presentation: 東京慈恵会医科大学
  • Year and Date: 20090725-20090726
• [Presentation] Inhibition of myostatin enhances the regenerative potential in atrophied muscle under unloading condition (2009)
  • Author(s): Goto, K.、Ohno, Y.、Hashimoto, N.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: Experimental Biology 2009
  • Place of Presentation: New Orleans、Louisiana、USA
  • Year and Date: 20090418-20090422
• [Presentation] ストレス応答の修飾による骨格筋の可塑性発現に関する基礎的研究 (2009)
  • Author(s): 後藤勝正、大野善隆、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 平成21年度筋生理の集い
  • Place of Presentation: 東京慈恵会医科大学
  • Year and Date: 2009-12-19
• [Presentation] 筋タンパク質分解系からみた熱ストレスとアスタキサンチン投与の組み合わせによる筋萎縮の抑制効果 (2009)
  • Author(s): 吉原利典、杉浦崇夫、芝口翼、山元勇樹、後藤勝正、磯山智美、内藤久士、大森大二郎、吉岡利忠
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 朱鷺メッセ、新潟市
  • Year and Date: 2009-09-18
• [Presentation] Effects of unloading on protein expression during the regeneration of injured soleus muscle of mice (2008)
  • Author(s): Goto, K.、Matsuba, Y.、Ohno, Y.、Sugiura, T.、Hashimoto, N.、Ohira, Y.、Yoshioka, T.
  • Organizer: The Integrative Biology of Exercise、2008 APS Intersociety Meeting
  • Place of Presentation: Hilton Head、South Carolina、USA
  • Year and Date: 20080924-20080927
• [Presentation] 骨格筋再生における荷重の生理学的意義とタンパク質発現の網羅的解析 (2008)
  • Author(s): 後藤勝正、大野善隆、松葉祐介、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 第63回日本体力医学会大会
  • Place of Presentation: 別府ビーコンプラザ, 別府市
  • Year and Date: 20080918-20080920
• [Presentation] 温熱を負荷した骨格筋のプロテオーム解析 (2008)
  • Author(s): 後藤勝正、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 第16回日本運動生理学会大会
  • Place of Presentation: 手塚山大学、奈良市
  • Year and Date: 20080801-20080803
• [Presentation] Effects of loading or unloading on the regenerative potential of injured skeletal muscle in mice、Life in Space for Life on Earth (2008)
  • Author(s): Goto, K.、Matsuba, Y.、Ohno, Y.、Sugiura, T.、Hashimoto, N.、Ohira, Y.、Yoshioka, T.
  • Organizer: 29th Annual International Society for Gravitational Physiology Meeting、10th ESA Life Sciences Symposium、24th Annual American Society for Gravitational and Space Biology Meeting、The ELGRA Symposium
  • Place of Presentation: Angers、France
  • Year and Date: 20080622-20080627
• [Presentation] Effects of hindlimb immobilization on Akt and GSK-3βsignals in regeneration of injured mouse skeletal muscle (2008)
  • Author(s): Naito, T.、Goto, K.、Morioka, S.、Matuba, Y.、Akema, T.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 京王プラザホテル、東京
  • Year and Date: 20080325-20080327
• [Presentation] Effects of loading/unloading on the regenerative potential of injured skeletal muscle in mice (2008)
  • Author(s): Matsuba, Y.、Goto, K.、Naito, T.、Sugiura, T.、Hashimoto, N.、Ohira, Y.、Yoshioka, T.
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 京王プラザホテル、東京
  • Year and Date: 20080325-20080327
• [Presentation] Effects of gravitational loading on protein expression during the regeneration of injured soleus muscle of mice (2008)
  • Author(s): Goto, K.、Sugiura, T.、Hashimoto, N.、Ohira, Y.、Yoshioka, T.
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 京王プラザホテル、東京
  • Year and Date: 20080325-20080327
• [Presentation] 骨格筋の再生能に対するloadingとミオスタチン機能の影響 (2008)
  • Author(s): 後藤勝正、大野善隆、橋本有弘、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 平成20年度筋生理の集い
  • Place of Presentation: 東京慈恵会医科大学
  • Year and Date: 2008-12-13
• [Presentation] 損傷骨格筋の再生に対する顆粒球コロニー刺激因子の促進作用 (2008)
  • Author(s): 内藤利仁、森岡成太、明間立雄、後藤勝正、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 名取の階段踊り場談話会「筋肉の構造と機能のシンポジウム」
  • Place of Presentation: 東京医科大学
  • Year and Date: 2008-03-24
• [Presentation] 損傷した骨格筋の再生における筋活動の影響 (2008)
  • Author(s): 松葉祐介、後藤勝正、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 名取の階段踊り場談話会「筋肉の構造と機能のシンポジウム」
  • Place of Presentation: 東京医科大学
  • Year and Date: 2008-03-24
• [Presentation] Geranylgeranylaceton increases protein content and heat shock protein 72 expression in skeletal muscle cells (2007)
  • Author(s): Goto, K.、Morioka, S.、Naito, T.、Kojima, A.、Akema, T.、Fujiya, H.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: 23rd Annual Meeting of American Society for Gravitational and Space Biology
  • Place of Presentation: NASA Ames Research Park、California、USA
  • Year and Date: 20071025-20071028
• [Presentation] 骨格筋再生過程における小胞体ストレス (2007)
  • Author(s): 後藤勝正、内藤利仁、松葉祐介、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: ノースアジア大学、秋田市
  • Year and Date: 20070914-20070916
• [Presentation] Antiulcer drug geranylgeranylaceton facilitates the differentiation of skeletal muscle cells、World Conference of Stress (2007)
  • Author(s): Goto, K.、Naito, T.、Morioka, S.、Kojima, A.、Matsuba, Y.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: 3rd Cell Stress Society International Congress on Stress Responses in Biology and Medicine
  • Place of Presentation: Budapest、Hungary
  • Year and Date: 20070823-20070826
• [Presentation] 損傷骨格筋の再生に対する温熱ストレスの影響 (2007)
  • Author(s): 後藤勝正、小島敦、森岡成太、内藤利仁、明間立雄、藤谷博人、杉浦崇夫、大平充宣、別府諸兄、青木治人、吉岡利忠
  • Organizer: 第28回日本炎症・再生医学会
  • Place of Presentation: 京王プラザホテル、東京
  • Year and Date: 20070802-20070803
• [Presentation] 損傷骨格筋の再生に及ぼすギプス固定および顆粒球コロニー刺激因子の影響 (2007)
  • Author(s): 内藤利仁、松葉祐介、後藤勝正、杉浦崇夫、吉岡利忠
  • Organizer: 第15回日本運動生理学会大会
  • Place of Presentation: ホテルニューキャッスル、弘前市
  • Year and Date: 20070726-20070727
• [Presentation] Antiulcer drug geranylgeranylaceton induces heat shock protein 72 in skeletal muscle cells and its physiological significance in muscle physiology (2007)
  • Author(s): Goto, K.、Morioka, S.、Naito, T.、Kojima, A.、Akema, T.、Matsuba, Y.、Fujiya, H.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: 2007 FASEB Summer Research Conference "Skeletal Muscle Stellite Cells and Stem Cells"
  • Place of Presentation: Indian Wells、California、USA
  • Year and Date: 20070714-20070719
• [Presentation] Effects of functional overloading on the regenerative potential of injured skeletal muscle in mice (2007)
  • Author(s): Goto, K.、Morioka, S.、Naito, T.、Akema, T.、Matsuba, Y.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: 28th Annual International Gravitational Physiology Meeting
  • Place of Presentation: San Antonio、Texas、USA
  • Year and Date: 20070408-20070413
• [Presentation] Effects of denervation and heat-stress on the regenerative process of injured skeletal muscles (2007)
  • Author(s): Morioka, S.、Naito, T.、Kojima, A.、Akema, T.、Goto, K.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: 第84回日本生理学会大会
  • Place of Presentation: 大阪国際交流センター、大阪市
  • Year and Date: 20070320-20070322
• [Presentation] ストレスに対する骨格筋の応答 (2007)
  • Author(s): 後藤勝正、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 平成19年度筋生理の集い
  • Place of Presentation: 東京慈恵会医科大学
  • Year and Date: 2007-12-15
• [Presentation] Role of Akt-related signaling pathway in heat stress-associated muscle hypertrophy (2006)
  • Author(s): Goto, K.、Morioka, S.、Naito, T.、Kojima, A.、Akema, T.、Sugiura, T.、Ohira, Y.、Yoshioka, T.
  • Organizer: Biochemistry of Exercise 13th International Conference
  • Place of Presentation: Seoul Olympic Parktel、Seoul、Korea
  • Year and Date: 20061020-20061023
• [Presentation] Muscle hypertrophy induced by heat-stress with low-intensity exercise in healthy humans (2006)
  • Author(s): Yoshioka, T.、Kojima, A.、Morioka, S.、Naito, T.、Sugiura, T.、Goto, K.
  • Organizer: 57th International Astronautical Congress
  • Place of Presentation: Valencia、Spain
  • Year and Date: 20061001-20061006
• [Presentation] 過負荷ストレスによる骨格筋再生過程の変化 (2006)
  • Author(s): 森岡茂太、内藤利仁、小島敦、明間立雄、後藤勝正、杉浦崇夫、大平充宣、吉岡利忠
  • Organizer: 第61回日本体力医学会大会
  • Place of Presentation: 神戸国際会議場、神戸市
  • Year and Date: 20060924-20060926
• [Presentation] 加齢による萎縮筋の回復過程における細胞内シグナル伝達の差異 (2006)
  • Author(s): 杉浦崇夫、後藤勝正、内藤久士、吉岡利忠
  • Organizer: 第61回日本体力医学会大会
  • Place of Presentation: 神戸国際会議場、神戸市
  • Year and Date: 20060924-20060926
• [Presentation] 発育期におけるラット骨格筋肥大に関するシグナル伝達系の変化 (2006)
  • Author(s): 杉浦崇夫、後藤勝正、内藤久士、吉岡利忠
  • Organizer: 第14回日本運動生理学会大会
  • Place of Presentation: 広島大学東広島キャンパス
  • Year and Date: 20060729-20060730
• [Book] Heat stress: A hypertrophic stimulus for skeletal muscles. Muscle Cell Physiology(Ohira, Y.) (2009)
  • Author(s): Goto, K., Ohira, Y., Yoshioka, T.
  • Total Pages: 41-50
  • Publisher: Osaka University
• [Book] 身体トレーニング-運動生理学からみた身体機能の維持・向上-(宮村実晴) (2009)
  • Author(s): 後藤勝正
  • Total Pages: 154-161
  • Publisher: 真興交易(株)医書出版部