2009 Fiscal Year Final Research Report
Studies on roles of translesion DNA synthesis in thresholds for genotoxic substances
| Project/Area Number |
18201010
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
NOUMI Takehiko National Institute of Health Sciences, 変異遺伝部, 部長 (30150890)
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| Co-Investigator(Kenkyū-buntansha) |
MASUMURA Kenichi 国立医薬品食品衛生研究所, 変異遺伝部, 主任研究官 (40291116)
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| Project Period (FY) |
2006 – 2009
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| Keywords | トキシコロジー / 遺伝毒性の閾値 / 有害化学物質 / 遺伝子 / 環境 / 癌 |
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| Research Abstract |
DNA polymerase kappa (Polκ) is an enzyme involved in DNA synthesis across DNA lesions (translesion DNA synthesis). We identified important amino acids involved in the translesion DNA synthesis and generated human cells and mice, whose Polκ activities were inactivated by specific amino acids substitutions. The results suggest that translesion DNA synthesis may be one of mechanisms underlying practical thresholds for genotoxicity. An international symposium on genotoxic and carcinogenic thresholds has been organized.
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[Presentation] A crucial role for the steric gate amino acid tyrosine 112 in efficient mismatched-primer extension by human DNA polymeraseκ2009
Author(s)
N. Niimi, A. Sassa, A. Katafuchi, P. Gruz, H. Fujimoto, R. -R. Bonala, F. Johnson, T. Ohta, T. Nohmi
Organizer
ASM Conferences, DNA Repair and Mutagenesis in Whistler
Place of Presentation
BC, Canada
Year and Date
20090530-20090605
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