2009 Fiscal Year Final Research Report
Search for Bioactive Natural Products for Molecular Target Chemotherapy of Cancer
| Project/Area Number |
18201042
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Osaka University |
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Principal Investigator |
KOBAYASHI Motomasa Osaka University, 大学院・薬学研究科, 教授 (40116033)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Shunji 大阪大学, 大学院・薬学研究科, 講師 (60252699)
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| Co-Investigator(Renkei-kenkyūsha) |
KOTOKU Naoyuki 大阪大学, 大学院・薬学研究科, 助教 (20362618)
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| Research Collaborator |
ARAI Masayoshi 大阪大学, 大学院・薬学研究科, 助教 (80311231)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 海洋生物 / 分子標的 / 海綿 / 血管新生 / 活性試験 / 抗がん剤 |
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| Research Abstract |
To explore new lead compounds for molecular target chemotherapy of cancer, we have established screening systems based on the novel biological and molecular biological findings of cancer. Then, we have searched bioactive natural compounds from the extracts libraries of marine organisms, marine-derived microbe and medicinal plants by constructed bioassay-guided separation. As a result, we have found seven bioactive compounds totally and examined total synthesis, structure-activity relationship, and synthesis of model compounds. Moreover, the mechanistic-studies were performed by the chemical biology method.
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[Journal Article] Structure-activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids.2007
Author(s)
Aoki, S. ; Watanabe, Y. ; Tanabe, D. ; Arai, M. ; Suna, H. ; Miyamoto, K. ; Tsujibo, H. ; Tsujikawa, K. ; Yamamoto, H. ; Kobayashi, M.
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Journal Title
Bioorg. Med. Chem 15
Pages: 6758-6762
Peer Reviewed
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[Journal Article] Cortistatin A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex.2006
Author(s)
Aoki, S. ; Watanabe, Y. ; Sanagawa, M. ; Setiawan, A. ; Kotoku, N. ; Kobayashi, M.
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Journal Title
J. Am. Chem. Soc 128
Pages: 3148-3149
Peer Reviewed
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