2009 Fiscal Year Final Research Report
Development of artificial receptor-based amplification system of dendritic cells for cancer therapy
| Project/Area Number |
18206083
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAGAMUNE Teruyuki The University of Tokyo, 大学院・工学系研究科, 教授 (20124373)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAHARA Masahiro 東京大学, 大学院・工学系研究科, 講師 (50345097)
YAMAGUCHI Satoshi 東京大学, 大学院・工学系研究科, 助教 (80398106)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 抗体 / 受容体 / 造血前駆細胞 / 増殖制御 / シグナル伝達 / がん治療 |
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| Research Abstract |
Since dendritic cells are potent antigen-presenting cells that can efficiently activate antigen-specific cytotoxic T cells, they are promising for application to cancer therapy. However, the method to efficiently expand dendritic cells has remained to be established. In this study, an artificial cytokine receptor recognizing antigen quite different from natural cytokines or growth factors was expressed in a hematopoietic stem cell, which is a source of dendritic cells. Consequently, we successfully demonstrated the expansion of hematopoietic stem cells via antigen-induced activation of the artificial cytokine receptor.
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[Journal Article] T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera2009
Author(s)
Sogo, T., Kawahara, M., Ueda, H., Otsu, M., Onodera, M., Nakauchi, H., Nagamune, T.
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Journal Title
Cytokine 46
Pages: 127-136
Peer Reviewed
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[Journal Article] Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera2008
Author(s)
Sogo, T., Kawahara, M., Tsumoto, K., Kumagai, I., Ueda, H., Nagamune, T.
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Journal Title
J.Immunol.Methods 337
Pages: 16-23
Peer Reviewed
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[Journal Article] Antigen-mediated migration of murine pro-B Ba/F3 cells via an antibody/receptor chimera2008
Author(s)
Kawahara, M., Shimo, Y., Sogo, T., Hitomi, A., Ueda, H., Nagamune, T.
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Journal Title
J.Biotechnol. 133
Pages: 154-161
Peer Reviewed
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[Journal Article] Antigen-mediated growth control of hybridoma cells via a human artificial chromosome2007
Author(s)
Kawahara, M., Inoue, T., Ren, X., Sogo, T., Yamada, H., Katoh, M., Ueda, H., Oshimura, M., Nagamune, T.
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Journal Title
Biochim.Biophys.Acta 1770
Pages: 206-212
Peer Reviewed
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[Journal Article] Growth control of hybridoma cells with an artificially induced EpoR-gp130 heterodimer2006
Author(s)
Kawahara, M., Ogo, Y., Tsumoto, K., Kumagai, I., Ueda, H., Nagamune, T.
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Journal Title
Cytotechnology 52
Pages: 171-179
Peer Reviewed
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[Journal Article] Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome2006
Author(s)
Yamada, H., Kunisato, A., Kawahara, M., Tahimic, C. G. T., Ren, X., Ueda, H., Nagamune, T., Katoh, M., Inoue, T., Nishikawa, M., Oshimura, M.
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Journal Title
J.Hum.Genet. 51
Pages: 147-150
Peer Reviewed
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[Book] Animal Cell Technology : Basic & Applied Aspects (Ikura, K. et al., Ed.), 15, (Construction of a fluorescein-responsive chimeric receptor with strict ligand dependency and analysis of the role of erythropoietin receptor domains in signal transduction)2009
Author(s)
Liu, W., Kawahara, M., Ueda, H., Nagamune, T.
Total Pages
187-193
Publisher
Springer
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[Book] Animal Cell Technology : Basic & Applied Aspects (Ikura, K. et al., Ed.), 15, (Promoting non-hematopoietic cell proliferation by chimeric receptors)2009
Author(s)
Tanaka, K., Kawahara, M., Ueda, H., Nagamune, T.
Total Pages
87-93
Publisher
Springer
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[Book] Animal Cell Technology : Basic & Applied Aspects (Ikura, K. et al., Ed.), 15, Selective expansion of genetically modified T cells using a chimeric IL-2 receptor for cancer therapy2009
Author(s)
Sogo, T., Kawahara, M., Ueda, H., Nagamune, T.
Total Pages
11-18
Publisher
Springer
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