2009 Fiscal Year Final Research Report
Brain energy-sensing mechanism controlling reproduction and food intake.
| Project/Area Number |
18208025
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nagoya University |
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Principal Investigator |
MAEDA Kei-ichiro Nagoya University, 大学院・生命農学研究科, 教授 (30181580)
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| Co-Investigator(Renkei-kenkyūsha) |
UENOYAMA Yoshihisa 名古屋大学, 大学院・生命農学研究科, 助教 (70324382)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 上位細胞 / ケトン体 / エネルギーセンサー / 摂食 / 血糖センサー / 神経ペプチド / ノルアドレナリン作動性神経 / 糖尿病 |
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| Research Abstract |
The present research project aims to demonstrate the presence of 'energy sensor' in the brain, Hindbrain ependymocytes are the candidate for the sensor detecting the blood levels of glucose, fatty acids and ketone bodies and integrating the information to regulate feeding, reproduction and energy homeostatis via specific neural pathways.
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[Journal Article] Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat.2010
Author(s)
Wakabayashi, Y., Nakada, T., Murata, K., Ohkura, S., Mogi, K., Navarro, M., V., Clifton, K., D., Mori, Y., Tsukamura, H., Maeda, K.-I., Steiner, A., R., Okamura, H.
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Journal Title
Journal of Neuroscience 30(8)
Pages: 3124-3132
Peer Reviewed
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[Journal Article] Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat.2009
Author(s)
Ohkura, S., Takase, K., Matsuyama, S., Mogi, K., Ichimura, T,, Wakabayashi, Y., Uenoyama, Y., Mori, Y., Steiner, R.A., Tsukamura, H., Maeda, K.-I., Okamura, H.
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Journal Title
Journal of Neuroendocrinology 21
Pages: 813-821
Peer Reviewed
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[Journal Article] Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats2009
Author(s)
Ohkura, S., Uenoyama, Y., Yamada, S., Homma, T., Takase, K., Inoue, N., Maeda, K.-I., Tsukamura, H.
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Journal Title
Peptides 30(1)
Pages: 49-56
Peer Reviewed
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[Journal Article] Possible Role of Oestrogen in Pubertal Increase of Kissl/Kisspeptin Expression in Discrete Hypothalamic Areas of Female Rats.2009
Author(s)
Takase, K., Uenoyama, Y., Inoue, N., Matsui, H., Yamada, S., Shimizu, M., Homma, T., Tomikawa, J., Kanda, S., Matsumoto, H., Oka, Y., Tsukamura, H., Maeda, K.-I.
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Journal Title
Journal of Neuroendocrinology. 21(6)
Pages: 527-37
Peer Reviewed
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[Journal Article] Food deprivation induces monocarboxylate transporter 2 expression in the brainstem of female rat.2009
Author(s)
Matsuyama, S., Ohkura, S., Iwata, K., Uenoyama, Y., Tsukamura, H., Maeda, K.-I., Kimura, K.
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Journal Title
Journal of Reproduction and Development 55
Pages: 256-261
Peer Reviewed
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[Journal Article] Oestrogen-dependent stimulation of luteinising hormone release by galanin-like peptide in female rats.2008
Author(s)
Uenoyama, Y., Tsukamura, H., Kinoshita, M., Yamada, S., Iwata, K., Pheng, V., Sajapitak, S., Sakakibara, M., Ohtaki, T., Matsumoto, H., Maeda, K,-I
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Journal Title
Journal of Neuroendocrinology 20
Pages: 626-631
Peer Reviewed
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[Journal Article] Central lipoprivation-induced suppression of LH pulses is mediated by paraventricular catecholaminergic inputs in female rats.2008
Author(s)
Sajapitak, S., Iwata, K., Shahab, M., Uenoyama, Y., Yamada, S., Kinoshita, M., Bari, F.Y., I'Anson, H., Tsukamura, H., Maeda, K.-I.
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Journal Title
Endocrinology 149
Pages: 3016-3024
Peer Reviewed
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[Journal Article] Paraventricularα1-andα2-adrenergic receptors mediate hindbrain lipoprivation-induced suppression of luteinizing hormone pulses in female rats.2008
Author(s)
Sajapitak, S., Uenoyama, Y., Yamada, S., Kinoshita, M., Iwata, K., Bari, F.Y., I' Anson, H., Tsukamura, H., Maeda, K.-I.
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Journal Title
Journal of Reproduction and Development 54
Pages: 198-202
Peer Reviewed
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[Journal Article] Temporal expression of estrogen receptorαin the hypothalamus and medulla oblongata during fasting: a role of noradrenergic neurons.2006
Author(s)
Reyes, B.A. S, Tsukamura, H., I' Anson, H., Estacio, M.A.C., Hirunagi, K., Maeda, K.-I.
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Journal Title
Journal of Endocrinology 190
Pages: 593-600
Peer Reviewed
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[Presentation] Ketone body is an orexigenic signal associated with diabetic hyperphagia in rats.2009
Author(s)
Iwata, K., Kinoshita, M., Yamada, S., Uenoyama, Y., Tsukamura, H., Maeda, K. -I.
Organizer
The 39th annual meeting of the Society for Neuroscience
Place of Presentation
Chicago, USA
Year and Date
20091017-20091021
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[Presentation] Identification and characterization of Kissl gene in pigs.2009
Author(s)
Tomikawa, J., Homma, T., Tajima, S., Shibata, T., Yamamoto, N., Uenoyama, Y., Ohkura, S., Tsukamura, H., Maeda, K. -I.
Organizer
The 39th annual meeting of the Society for Neuroscience
Place of Presentation
Chicago, USA.
Year and Date
20091017-20091021
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[Presentation] Role of kisspeptin (metastin)-GPR54 System in Regulating Surge- and Pulse-Modes of GnRH/onadotropin release in rats.2008
Author(s)
Tsukamura, H., Homma, T., Yamada, S., Inamoto, Y., Inoue, N., Ohkura, S., Uenoyama, Y., Maeda, K.I.
Organizer
1st world conference on kisspeptin signaling in the brain
Place of Presentation
Cordoba, Spain.
Year and Date
20081008-20081010
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