The production of high functional materials from biomass lignin by the fusion technology of molecular biology and organic material science

2008 Fiscal Year Final Research Report

• Project/Area Number: 18208027
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Boundary agriculture
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: KATAYAMA Yoshihiro Tokyo University of Agriculture and Technology, 大学院・共生科学技術研究院, 教授 (10214339)
• Co-Investigator(Kenkyū-buntansha): SHIGEHARA Kiyotaka 東京農工大学, 大学院・共生科学技術研究院, 教授 (60170867) ; MASAI Eiji 長岡技術科学大学, 工学部, 准教授 (20272867) ; NAKAMURA Masaya 森林総合研究所, きのこ微生物研究領域, 微生物機能解析チーム長 (50353793) ; OHARA Seiji 森林総合研究所, バイオマス化学研究領域, 領域長 (20353617) ; KAJITA Shinya 東京農工大学, 大学院・共生科学技術研究院, 准教授 (40323753)
• Project Period (FY): 2006 – 2008
• Keywords: 植物バイオマス / リグニン / タンニン / 微生物 / 遺伝子工学 / バイオリアクター / 機能性有機材料 / バイオプラスチックス

Research Abstract

本研究は生命科学と有機材料科学を基盤に、リグニンやタンニンなど複雑な化学構造を持つ植物バイオマス成分から、微生物機能を用いて一旦単純な構造の中間物質2-ピロン-4, 6-ジカルボン酸(PDC)に高收率変換し、テレフタル酸、L-乳酸、コハク酸等と重縮合させる事により機能性高分子材料を設計生産する新しいリグニン利用技術を開発した。

Research Products

• [Journal Article] Polyesters of 2-pyrone-4,6-dicarboxylic acid (PDC) as bio-based plastics exhibiting strong adhering properties (2009)
  • Author(s): M Hishida, K Shikinaka, Y Katayama, S Kajita, E Masai, M Nakamura, Y Otsuka, S Ohara, K Shigehara
  • Journal Title: Polymer J 41 Pages: 297-302
  • Peer Reviewed
• [Journal Article] Enzymatic properties of terephthalate 1,2-dioxygenase of Comamonas sp. strain E6 (2008)
  • Author(s): Y Fukuhara, D Kasai, Y Katayama, M Fukuda, E Masai
  • Journal Title: Biosci Biotechnol Biochem 72 Pages: 2335-2341
  • Peer Reviewed
• [Journal Article] A novel biomass-based polymer prepared from lignin-derived stable metabolic intermediate by copper(I)-catalyzed azide-alkyne click reaction (2008)
  • Author(s): T Michinobu, Y Inazawa, K Hiraki, Y Katayama, E Masai, M Nakamura, S Ohara, K Shigehara
  • Journal Title: Chem Lett 37 Pages: 154-155
  • Peer Reviewed
• [Journal Article] Genetic and biochemical investigations on bacterial catabolic pathways for lignin-derived aromatic compounds (2007)
  • Author(s): E Masai, Y Katayama, M Fukuda
  • Journal Title: Biosci Biotechnol Biochem 71 Pages: 1-15
  • Peer Reviewed
• [Journal Article] Molecular properties of 2-pyrone-4,6- dicarboxylic acid (PDC) as a stable metabolic intermediate of lignin isolated by fractional precipitation with Na^+ ion (2007)
  • Author(s): T Michinobu, M Bito, Y Yamada, Y Katayama, K Noguchi, E Masai, M Nakamura, S Ohara, K Shigehara
  • Journal Title: Bull Chem Soc Jpn 80 Pages: 2436-2442
  • Peer Reviewed
• [Journal Article] Efficient production of 2-pyrone 4,6-dicarboxylic acid as a novel polymer-based materialfrom protocatechuate by microbial function (2006)
  • Author(s): Y Ohtsuka, M Nakamura, K Shigehara. K Sugimura, E Masai, S Ohara, Y Katayama
  • Journal Title: Appl Microbiol Bioterch 71 Pages: 608-614
  • Peer Reviewed
• [Presentation] Bioconversion of lignin-related compounds to a novel polymer material, 2-oxopyran-2H-2,6-dicarboxylic acid (2008)
  • Author(s): K Mase, Y Otsuka, E Masai, M Nakamura, S Kajita, M Fukuda, S Ohara, K Shigehara,Y Katayama
  • Organizer: 11th Cell Wall Meeting
  • Place of Presentation: Copenhagen
  • Year and Date: 2008-08-13
• [Presentation] Production of novel polymer-based material from lignin derivatives by microbial function (2007)
  • Author(s): Y Otsuka, M Nakamura, E Masai, S Ohara, S Kajita, K Shigehara, Y Katayama
  • Organizer: International Congress on Biotechnology in the Pulp and Paper Industry
  • Place of Presentation: Madison, Wisconsin, USA
  • Year and Date: 20070710-16
• [Presentation] Enzymatic Properties of terephthalate 1,2-dioxygenase from Comamonas sp. strain E6 (2007)
  • Author(s): Y Fukuhara, E Masai, Y Katayama, M Fukuda
  • Organizer: American Society for Microbiology, General 107th Meeting
  • Place of Presentation: Toronto, Canada
  • Year and Date: 20070522-24
• [Presentation] Selective Na^+ ion complexation by biomass-based linear polymers prepared from lignin-derived stable intermediate (2007)
  • Author(s): T Michinobu, Y Inazawa, M Bitoh, Y Ohtsuka, M Nakamura, E Masai, S Kajita, Y Katayama, S Ohara, K Shigehara
  • Organizer: 12th IUPAC International Symposium on MacroMolecular Complexes
  • Place of Presentation: Fukuoka
  • Year and Date: 2007-08-29
• [Presentation] 生命科学と有機材料科学を基盤としたリグニンの新しい高度利用に関する研究(I) (2006)
  • Author(s): 大塚祐一郎、中村雅哉、杉村耕介、政井英司、重原淳孝、片山義博、大原誠資
  • Organizer: 第51回リグニン討論会
  • Place of Presentation: 札幌
  • Year and Date: 2006-10-27
• [Remarks] 新春学長記者会見(東京農工大学学長,平成21年1月22日)会場:東京商工会議所 東京都千代田区丸の内3-2-2「植物体からエポキシ樹脂の3倍の強度をもつ接着剤を開発」
• [Remarks] 新聞報道○日刊工業新聞(2009.1.23)○日経産業新聞(2009.1.23)
• [Remarks] ネット、ホームページ○日経BPバイオテク(WEB)(植物体から接着剤)
  • URL: http://biotech.nikkeibp.co.jp/bionewsn/detail.jsp?id=20059028&newsid=SPC2009012261420&pg_nm=1&sai1=1&new1=1&news1=1&icate=0&yunw=1
• [Remarks] 長岡技術科学大学広報誌VOS
  • URL: http://www.nagaokaut.ac.jp/j/annai/vos/vos_149.pdf
• [Patent(Industrial Property Rights)] ポリエステル、ポリウレタン及びそれらの製造法 (2008)
  • Inventor(s): 片山義博、重原淳孝、高島宏明、山本裕輔、間瀬浩平、下俊久、阿部友邦、政井英司、大原誠資、中村雅哉、大塚祐一郎
  • Industrial Property Number: 特願:2008-235504
  • Filing Date: 2008-09-12
• [Patent(Industrial Property Rights)] エポキシ樹脂組成物及びその製造方法 (2008)
  • Inventor(s): 片山義博、重原淳孝、山本裕輔、政井英司、大原誠資、中村雅哉、大塚祐一郎
  • Industrial Property Number: 特願2008-226284
  • Filing Date: 2008-09-03
• [Patent(Industrial Property Rights)] 組換えプラスミド、形質転換体及び2H-ピラン-2-オン4, 6-ジカルボン酸の製造法 (2007)
  • Inventor(s): 片山義博、梶田真也、重原淳孝、村瀬仁俊、間瀬浩平、大原誠資、中村雅哉、大塚祐一郎、福田雅夫、政井英司
  • Industrial Property Number: 特願2007-255636
  • Filing Date: 2007-09-28
• [Patent(Industrial Property Rights)] PDC-乳酸コポリエステル及びその成形体 (2007)
  • Inventor(s): 片山義博、重原淳孝、間瀬浩平、下俊久、大原尚己
  • Industrial Property Number: 特願2008-522330/WO2007/148471
  • Filing Date: 2007-04-17