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2007 Fiscal Year Annual Research Report

神経ペプチドPACAPの機能と疾患への分子基盤の解明

Research Project

Project/Area Number 18209009
Research InstitutionOsaka University

Principal Investigator

馬場 明道  Osaka University, 薬学研究科, 教授 (70107100)

Co-Investigator(Kenkyū-buntansha) 橋本 均  大阪大学, 薬学研究科, 准教授 (30240849)
新谷 紀人  大阪大学, 薬学研究科, 助教 (10335367)
塩田 清二  昭和大学, 医学部, 教授 (80102375)
矢田 俊彦  自治医科大学, 医学部, 教授 (60166527)
橋本 亮太  大阪大学, 子どものこころの分子制御機構研究センター, 特任助教 (10370983)
KeywordsPACAP / 遺伝子改変マウス / 精神疾患・障害 / 統合失調症 / SNPs(一塩基多型) / プロスタグーンジンD_2合成酵素 / 膵島過形成 / ミトコンドリア
Research Abstract

本研究は、中枢神経系(記憶、リズム制御、精神運動機能)および膵臓(インスリン分泌、ランゲルハンス島(ラ氏島)形成)の機能におけるPACAPの作用機構と変異マウス表現型の分子基盤解明を行い、それらをヒト疾患の症候・中間表現型へ比較・外挿することで、疾患の分子基盤としてのPACAPシグナル系の意義を確立することを目的として計画・実施し、平成19年度は以下の成果を得た。
1)PACAP-KO(PACAP欠損マウス)の中枢表現型の解析過程で、飼育環境条件が表現型の発現強度に大きく関与することを見出し、その環境要因の影響を高感度で評価できる実験系を確立した。
2)PACAP-KOの概日リズム制御異常に関わる遺伝子としてリポカリン型プロスタグランジンD_2(PGD_2)合成酵素を同定し、同遺伝子およびPGD_2受容体のリズム制御中枢における発現局在等を明らかにした。
3)PACA-KOで光照射による交感神経活性化や視交叉上核(SCN)のCREB発現がほぼ完全に消失することを見出し、PACAPによるSCNでの転写活性化が種々の非視覚光受容反応の発現に関わることを示唆した。
4)PACAP-KOではストレス負荷に伴う血中コルチコステロン(COR)上昇が顕著に減弱するのに対し、上位ホルモン誘発のCOR分泌が正常なこと等を示し、外部知覚入力におけるPACAPの重要性を示唆した。
5)臨床遺伝学的解析から、ヒトPACAP遺伝子上の特定の一塩基多型と大うつ病との関連を見出した。
6)網羅的遺伝子発現解析で同定したRegIIIβがPACAPの標的分子として働くことを機能的に実証し、ラ氏島で過形成制御に特異的に関与する一方、腺房細胞においては炎症制御に関わることを見出した。
7)ラ氏島過形成関与分子として同定した機能未知分子HPGBが、核あるいはミトコンドリアを標的としてミトコンドリアの形態および機能制御に関わる、新規の細胞内因子である可能性を見出した。
8)PACAP-KOで白色脂肪の減少をはじめとする種々のエネルギー代謝機能異常を明らかにした。

  • Research Products

    (83 results)

All 2009 2008 2007 Other

All Journal Article (35 results) (of which Peer Reviewed: 23 results) Presentation (45 results) Remarks (3 results)

  • [Journal Article] PACAP provides colonic protection against dextran sodium sulfate induced colitis2008

    • Author(s)
      Azuma YT
    • Journal Title

      J Cell Physiol (In press)

    • Peer Reviewed
  • [Journal Article] Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor inmaging2008

    • Author(s)
      Hashimoto R
    • Journal Title

      The World Journal of Biological Psychiatry (in press)

    • Peer Reviewed
  • [Journal Article] Neuropsychotoxicity of Abused Drugs: Effects of Serotonin Receptor Ligands on Methamphetamine-and Cocaine-Induced Behavioral Sensitization in Mice2008

    • Author(s)
      Ago Y
    • Journal Title

      J Pharmacol Sci 106

      Pages: 15-21

    • Peer Reviewed
  • [Journal Article] A possible association between missense polymorphism of the Breakpoint Cluster Region gene and lithium prophylaxis in bipolar disorder2008

    • Author(s)
      Masui T
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry 32

      Pages: 204-208

    • Peer Reviewed
  • [Journal Article] Distribution and localization of pituitary adenylate cyclase activating polypeptide-specific receptor (PAC1R) in the rostral migratory stream of the infant mouse brain2008

    • Author(s)
      Matsuno R
    • Journal Title

      Regul Pept 145(1-3)

      Pages: 80-87

    • Peer Reviewed
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) colocalize with activity-dependent neuroprotective protein (ADNP) in the mouse brain2008

    • Author(s)
      Nakamachi T
    • Journal Title

      Regul Pept 145(1-3)

      Pages: 88-95

    • Peer Reviewed
  • [Journal Article] 統合失調症の分子病態とPACAP2008

    • Author(s)
      新谷紀人
    • Journal Title

      脳と精神の医学 (In press)

  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia2007

    • Author(s)
      Hashimoto R
    • Journal Title

      Mol Psychiatry 12

      Pages: 1026-1032

    • Peer Reviewed
  • [Journal Article] A novel DISCI-interacting partner DBZ (DISC1-Binding Zinc finger protein): implication in the modulation of DISC1-dependent neurite outgrowth2007

    • Author(s)
      Hattori T
    • Journal Title

      Mol Psychiatry 12

      Pages: 398-407

    • Peer Reviewed
  • [Journal Article] Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice2007

    • Author(s)
      Fujii H
    • Journal Title

      Peptides 28(9)

      Pages: 1674-1679

    • Peer Reviewed
  • [Journal Article] Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test2007

    • Author(s)
      Ago Y
    • Journal Title

      J Pharmacol Sci 104(2)

      Pages: 153-158

    • Peer Reviewed
  • [Journal Article] Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist2007

    • Author(s)
      Koyama Y
    • Journal Title

      Neuroreport 18(12)

      Pages: 1275-1279

    • Peer Reviewed
  • [Journal Article] Edaravone (3-Methy-l-phenyl-2-pyrazolin-5-one), a Radical Scavenger, Prevents 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced Neurotoxicity in Substantia Nigra but Not the Striatum2007

    • Author(s)
      Kawasaki T
    • Journal Title

      J Pharmacol Exp Ther 322

      Pages: 274-281

    • Peer Reviewed
  • [Journal Article] Nitric Oxide-Induced Apoptosis in Cultured Rat Astrocytes: Protection by Edaravone, a Radicla Scavenger2007

    • Author(s)
      Kawasaki T
    • Journal Title

      Glia 55

      Pages: 1325-1333

    • Peer Reviewed
  • [Journal Article] Ritanserin Reverses Repeated Methamphetamine-Induced Behavioral and Neurochemical Sensitization in Mice2007

    • Author(s)
      Ago Y
    • Journal Title

      Synapse 61

      Pages: 757-763

    • Peer Reviewed
  • [Journal Article] Roles of postsynaptic serotonin receptors in risperidone-induced increase in acetylcholine release in rat prefrontal contrex2007

    • Author(s)
      Sato M
    • Journal Title

      Eur. J. Pharmacol 559

      Pages: 155-160

    • Peer Reviewed
  • [Journal Article] Edaravone, a Radical Scavenger, Inhibis Mitochondrial Permeability Transition Pore in Rat Brain2007

    • Author(s)
      Takayasu Y
    • Journal Title

      J. Pharmacol Sci 103

      Pages: 434-437

    • Peer Reviewed
  • [Journal Article] AMPA-mediated excitotoxicity in oligodendorocytes: role for Na(+)-K-Cl(-) co-transport and reversal of Na(+)/Ca(2+) exchanger2007

    • Author(s)
      Chen H
    • Journal Title

      J Neurochem. 102(6)

      Pages: 1783-1795

    • Peer Reviewed
  • [Journal Article] Ca2+ extrusion in aged smooth muscle cells2007

    • Author(s)
      Gomez-Pinilla PJ
    • Journal Title

      Biochem Pharmacol 74(6)

      Pages: 860-869

    • Peer Reviewed
  • [Journal Article] Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression oftissue inhibitor of matrix metalloprotease-1 and -3 in rat brain2007

    • Author(s)
      Koyama Y
    • Journal Title

      Neuroscience 147

      Pages: 620-630

    • Peer Reviewed
  • [Journal Article] A possible association between the Val158Met polymorphism of the catechol-0-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects2007

    • Author(s)
      Hashimoto R
    • Journal Title

      Neurosci lett 428(1)

      Pages: 17-20

    • Peer Reviewed
  • [Journal Article] Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi2007

    • Author(s)
      Hattori S
    • Journal Title

      Behavioural Brain Research 180(1)

      Pages: 69-76

    • Peer Reviewed
  • [Journal Article] Postsynaptic density: A key convergent site for schizophrenia susceptibility factors and possible target for drug development2007

    • Author(s)
      Hashimoto R
    • Journal Title

      Drugs Today (Barc) 43(9)

      Pages: 645-654

    • Peer Reviewed
  • [Journal Article] Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development2007

    • Author(s)
      Watanabe J
    • Journal Title

      Peptides 28(9)

      Pages: 1713-1719

  • [Journal Article] PACAP in the glucose and energy homeostasis: physiological role and therapeutic potential. In: Therapeutic Potential of VIP and PACAP2007

    • Author(s)
      Nakata M
    • Journal Title

      Curr Pharm Des 13(11)

      Pages: 1105-1112

    • Peer Reviewed
  • [Journal Article] Molecular Pharmacologic Approaches to Functional A nalysis of New Biological Molecules for Drug Discovery2007

    • Author(s)
      Baba A
    • Journal Title

      Yakugaku Zasshi 127(10)

      Pages: 1643-1654

  • [Journal Article] Recent studies on the trimethyltin actions in central nervous systems2007

    • Author(s)
      Shintani N
    • Journal Title

      Yakugaku Zasshi 127(3)

      Pages: 451-461

  • [Journal Article] The neuropeptide PACAP and neuropsychological function: unexpected insights from mouse mutants2007

    • Author(s)
      Hashimoto H
    • Journal Title

      Seikagaku 79(4)

      Pages: 375-379

  • [Journal Article] 新しいGPCRリガンド研究の現状と展望〜神経ペプチドPACAPの生理機能2007

    • Author(s)
      新谷紀人
    • Journal Title

      ホルモンと臨床 55

      Pages: 131-139

  • [Journal Article] 統合失調症とセロトニン1A受容体2007

    • Author(s)
      吾郷由希夫
    • Journal Title

      脳21 10(3)

      Pages: 44-48

  • [Journal Article] 遺伝子改変マウスの表現型解析法:SHIRPA一次スクリーニング法2007

    • Author(s)
      笠井淳司
    • Journal Title

      日本薬理学雑誌 130

      Pages: 281-285

  • [Journal Article] 動物個体を用いた概日リズム解析法2007

    • Author(s)
      川口ちひろ
    • Journal Title

      日本薬理学雑誌 130

      Pages: 193-199

  • [Journal Article]2007

    • Author(s)
      馬場明道
    • Journal Title

      神経ペプチドPACAP-新しい創薬標的分子探索へ 遺伝子医学MOOK(8)

      Pages: 168-172

  • [Journal Article]2007

    • Author(s)
      新谷紀人
    • Journal Title

      PACAP欠損マウス, Keyword精神第4版

      Pages: 214-215

  • [Journal Article]2007

    • Author(s)
      馬場明道
    • Journal Title

      ビタミン, New薬理学改訂第5版

      Pages: 193-203

  • [Presentation] Symposium: Pathogenesis of schizophrenia, dysbindin and pathogenesis of schizophrenia2009

    • Author(s)
      Hashimoto R
    • Organizer
      2^<nd> International Congress of Biological Psychiatry
    • Place of Presentation
      Santiago, Chili
    • Year and Date
      20090417-20090421
  • [Presentation] Roles of a neuropeptide, PACAP, on psychomotor function and photoentrainment2008

    • Author(s)
      Baba A
    • Organizer
      The 19th Korea-Japan Joint Seminor on Pharmacology, The 60th Annual meeting of the Korean Society of Pharmacology
    • Place of Presentation
      釜山, 韓国
    • Year and Date
      20081107-20081108
  • [Presentation] Neuropeptide PACAP is involved in certain types of light-induced physiological responses2008

    • Author(s)
      Hatanaka M
    • Organizer
      The 19th Korea-Japan Joint Seminor on Pharmacology
    • Place of Presentation
      釜山, 韓国
    • Year and Date
      20081107-20081108
  • [Presentation] PACAP Signaling: A promising drug target for neuropsychological disorders2008

    • Author(s)
      Hashimoto H
    • Organizer
      Ehrlich II-2nd World Confbrence on Magic Bullets
    • Place of Presentation
      Nurnberg, Germany
    • Year and Date
      20081003-20081005
  • [Presentation] 微小組織特異的網羅的遺伝子発現解析による神経ペプチドPACAPの標的分子同定2008

    • Author(s)
      新谷紀人
    • Organizer
      日本薬学会128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
  • [Presentation] PACAP遺伝子欠損マウスにおける非視覚光受容反応の障害2008

    • Author(s)
      畑中道賢
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
  • [Presentation] 概日リズムの光誘発性位相前進に特異的な新規シグナル系の同定2008

    • Author(s)
      中村玲子
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
  • [Presentation] 統合失調症脆弱性遺伝子ディスバインジンの遺伝子改変動物による分子病態研究2007

    • Author(s)
      橋本亮太
    • Organizer
      統合脳5領域「平成19年度 冬の合同班会議」
    • Place of Presentation
      東京
    • Year and Date
      20071222-20071224
  • [Presentation] ES細胞からの新規神経細胞分化誘導系の確立2007

    • Author(s)
      嶋田健
    • Organizer
      ファーマバイオフォーラム2007
    • Place of Presentation
      大阪
    • Year and Date
      20071201-20071202
  • [Presentation] 新規機能未知遺伝子HPGBのミトコンドリアにおける機能解析2007

    • Author(s)
      池田和哉
    • Organizer
      ファーマバイオフォーラム2007
    • Place of Presentation
      大阪
    • Year and Date
      20071201-20071202
  • [Presentation] Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Attenuates Focal Cerebral Ischemic Injury via Bcl-2 and IL-6 Signaling2007

    • Author(s)
      Tomoya Nakamachi
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      20071103-20071107
  • [Presentation] Involvement of beta isoform of protein kinase C in the PACAP-induced differentiation of neural stem cells into astrocytes2007

    • Author(s)
      Jun Watanabe
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      20071103-20071107
  • [Presentation] Translational Research for Schizophrenia2007

    • Author(s)
      Hashimoto R
    • Organizer
      4^<th> Japanese-German Frontiers of Science Symposium
    • Place of Presentation
      Shonan, Japan
    • Year and Date
      20071101-20071104
  • [Presentation] Genetic variations in the dysbindin gene are associated with human memory performance2007

    • Author(s)
      Hashimoto R
    • Organizer
      IPA 2007 Osaka Silver Congress
    • Place of Presentation
      Osaka
    • Year and Date
      20071014-20071018
  • [Presentation] 成体神経幹細胞に対する下垂体アデニル酸シクラーゼ活性化ポリペプチド(PACAP)の作用2007

    • Author(s)
      中町智哉
    • Organizer
      第32回日本比較内分泌学会大会
    • Place of Presentation
      東京
    • Year and Date
      20071012-20071013
  • [Presentation] in vitro及びin vivoにおけるPACAPの神経幹細胞に対するアストロサイト分化誘導作用2007

    • Author(s)
      渡邊潤
    • Organizer
      第32回日本比較内分泌学会大会
    • Place of Presentation
      東京
    • Year and Date
      20071012-20071013
  • [Presentation] Serotonin 1A (5-HT1A) agonist decreases locomotor activity and prefrontal neuronal activation in amphetamine treated mice2007

    • Author(s)
      Rie Tsuchida
    • Organizer
      Neuro2007
    • Place of Presentation
      Yokohana, Japan
    • Year and Date
      20070910-20070912
  • [Presentation] Involvement of environmental factors in the expression of psychomotor abnormalities in PACAP knock-out mice2007

    • Author(s)
      Toshihiro Ishihama
    • Organizer
      Neuro2007
    • Place of Presentation
      Yokohana, Japan
    • Year and Date
      20070910-20070912
  • [Presentation] PACAP遺伝子は統合失調症と関連する2007

    • Author(s)
      橋本亮太
    • Organizer
      第50回日本神経化学会・第30回日本神経科学学会・第17回日本神経回路学会合同年会
    • Place of Presentation
      横浜
    • Year and Date
      20070910-20070912
  • [Presentation] PACAP deficient mice exhibit light parameter dependent abnormalities of nonvisual photoreception2007

    • Author(s)
      Yasushi Isojima
    • Organizer
      Neuro2007
    • Place of Presentation
      Yokohana, Japan
    • Year and Date
      20070910-20070912
  • [Presentation] Functional significance of PACAP on neuroprotection and neurodevelopment2007

    • Author(s)
      Seiji Shioda
    • Organizer
      8th International Symposium for VIP, PACAP and Related Peptides
    • Place of Presentation
      Manchester, VT, USA
    • Year and Date
      20070903-20070908
  • [Presentation] Distribution of activity-dependent neuroprotective protein (ADNP) and (PACAP) type 1 receptor (PAC1R) in the mouse brain2007

    • Author(s)
      Tomoya Nakamachi
    • Organizer
      8th International Symposium for VIP, PACAP and Related Peptides
    • Place of Presentation
      Manchester, VT, USA
    • Year and Date
      20070903-20070908
  • [Presentation] THE ROLE OF PACAP IN ASTROGLISL DIFFERENTIATION IN VIVO AND IN VITRO2007

    • Author(s)
      Jun Watanabe
    • Organizer
      8th International Symposium for VIP, PACAP and Related Peptides
    • Place of Presentation
      Manchester, VT, USA
    • Year and Date
      20070903-20070908
  • [Presentation] Effect of PACAP on neuronal progenitor cells in vivo2007

    • Author(s)
      Daisuke Hayashi
    • Organizer
      8th International Symposium for VIP, PACAP and Related Peptides
    • Place of Presentation
      Manchester, VT, USA
    • Year and Date
      20070903-20070908
  • [Presentation] THE ROLE OF PACAP IN ASTROGLIAL DIFFERENTIATION IN VIVO AND IN VITRO2007

    • Author(s)
      Jun Watanabe
    • Organizer
      8th International Symposium for VIP, PACAP and Related Peptides
    • Place of Presentation
      Manchester, VT, USA
    • Year and Date
      20070903-20070908
  • [Presentation] 神経ペプチドであるPACAPと統合失調症の関連:脳構造、記憶、抗精神病薬を用いた統合的解析2007

    • Author(s)
      橋本亮太
    • Organizer
      統合脳5領域「平成19年度 夏の合同班会議」
    • Place of Presentation
      札幌
    • Year and Date
      20070821-20070824
  • [Presentation] 統合失調症脆弱性遺伝子であるディスバインジン欠損マウスにおける異常行動2007

    • Author(s)
      橋本亮太
    • Organizer
      第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Year and Date
      20070711-20070713
  • [Presentation] DISC1遺伝子Ser704Cys機能多型はうつ病のリスク、ヒトの脳構造、神経細胞保護に影響を与える2007

    • Author(s)
      橋本亮太
    • Organizer
      第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Year and Date
      20070711-20070713
  • [Presentation] 統合失調症脆弱性遺伝子ディスバインジンによる統合失調症の病態解明研究2007

    • Author(s)
      橋本亮太
    • Organizer
      第103回日本精神神経学会総会
    • Place of Presentation
      高知
    • Year and Date
      20070517-20070519
  • [Presentation] マウス脳におけるADNPとPACAP特異的受容体の分布・局在2007

    • Author(s)
      中町智哉
    • Organizer
      第4回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      20070511-20070512
  • [Presentation] II型糖尿病病態下におけるPACAP-RegIIIβシグナルによる膵β細胞機能制御2007

    • Author(s)
      新谷紀人
    • Organizer
      次世代を担う若手医療科学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-12-16
  • [Presentation] 神経ペプチドPACAPによる膵β細胞機能調節2007

    • Author(s)
      新谷紀人
    • Organizer
      第35回薬物活性シンポジウム
    • Place of Presentation
      広島
    • Year and Date
      2007-11-29
  • [Presentation] セルレイン誘発性急性膵炎におけるPACAPの役割2007

    • Author(s)
      桜井佑介
    • Organizer
      第112回日本薬理学会近畿部会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-16
  • [Presentation] 新規因子Hyperplasia-associated gene of beta cell (HPGB)によるミーコンドリア機能制御2007

    • Author(s)
      北村和之
    • Organizer
      第112回日本薬理学会近畿部会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-16
  • [Presentation] 種々のADHD治療薬と5-HT_<1A>受容体アゴニストの併用投与による自発運動抑制作用2007

    • Author(s)
      久保勝裕
    • Organizer
      第112回日本薬理学会近畿部会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-16
  • [Presentation] PACAP-REGULATED BETA-CELL PROLIFERATION: IMPLICATION OF RegIIIBETA2007

    • Author(s)
      K Hamagami
    • Organizer
      8th International Symposium for VIP, PACAP and Related Peptides
    • Place of Presentation
      Manchester, Vermont, USA
    • Year and Date
      2007-09-05
  • [Presentation] Neuroprotective mechanism of PACAP associated with IL-6 signaling2007

    • Author(s)
      Tomoya Nakamachi
    • Organizer
      8th International Symposium for VIP, PACAP and Related Peptides
    • Place of Presentation
      Manchester, Vermont, USA
    • Year and Date
      2007-09-05
  • [Presentation] EVIDENCE THAT THE PACAP GENE CONTRIBUTES TO THE RISK OF SCHIZOPHRENIA2007

    • Author(s)
      Hitoshi Hashimoto
    • Organizer
      8th International Symposium for VIP, PACAP and Related Peptides
    • Place of Presentation
      Manchester, Vermont, USA
    • Year and Date
      2007-09-05
  • [Presentation] 大阪大学における統合失調症外来について2007

    • Author(s)
      橋本亮太
    • Organizer
      第3回大阪北部精神科症例検討会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-25
  • [Presentation] 統合失調症の分子病態と神経ペプチドPACAP2007

    • Author(s)
      新谷紀人
    • Organizer
      第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-11
  • [Presentation] PACAP遺伝子欠損マウスの異常行動発現における環境因子の役割2007

    • Author(s)
      石濱壽紘
    • Organizer
      第29回日本生物学的精神医学会・第37回日本神経精神薬理学会合同年会
    • Place of Presentation
      札幌
    • Year and Date
      2007-07-11
  • [Presentation] 第二世代抗精神病薬と認知機能との関連について-リスペリドンと他剤との比較-2007

    • Author(s)
      橋本亮太
    • Organizer
      第3回大阪中央精神科症例検討会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-05
  • [Presentation] Hyperplasia-associated gene of beta cell(HPGB)の機能解析2007

    • Author(s)
      池田和哉
    • Organizer
      第111回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-15
  • [Presentation] 膵b細胞増殖、インスリン分泌能におけるPACAP-RegIIIbシグナルの役割2007

    • Author(s)
      楠本慶介
    • Organizer
      第111回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-15
  • [Presentation] 中間表現型と遺伝子2007

    • Author(s)
      橋本亮太
    • Organizer
      第6回Schizophrenia研究会
    • Place of Presentation
      高知
    • Year and Date
      2007-05-19
  • [Remarks]

    • URL

      http://www.phs.osaka-u.ac.jp/homepage/b010/index.html

  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/psy/www/jp/labo/sp/index.htm

  • [Remarks]

    • URL

      http://www10.showa-u.ac.jp/~anat-1/index.html

URL: 

Published: 2010-06-11   Modified: 2016-04-21  

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