2008 Fiscal Year Self-evaluation Report
Multidimensional approaches to molecular basis of schizophrenia
Project/Area Number |
18209012
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human genetics
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Research Institution | Kyushu University |
Principal Investigator |
FUKUMAKI Yasuyuki Kyushu University, 生体防御医学研究所, 教授 (90128083)
|
Project Period (FY) |
2006 – 2009
|
Keywords | 多因子病 / 精神疾患 / 関連解析 / 多型 / グルタミン酸 / 遺伝子改変マウス |
Research Abstract |
多数存在すると考えられる統合失調症感受性遺伝子を、ゲノムワイド探索とともに候補遺伝子探索の両面から統計遺伝学的な手法を用いてできるだけ同定し、可能なものについては細胞レベルや個体レベルでの解析を行うことにより、機能面での裏付けを得る。さらに再現性の高い遺伝子についてはそれら遺伝子の関わるネットワークを解析することにより、疾患の分子機構を遺伝子ネットワークの面から明らかにする。
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Research Products
(18 results)
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[Journal Article] Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia2009
Author(s)
Shibata, H., Tani, A., Chikuhara, T., Kikuta, R., Sakai, M., Ninomiya, H., Tashiro, N., Iwata, N., Ozaki, N., Fukumaki, Y.
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Journal Title
Psychiatric Res 167
Pages: 88-96
Peer Reviewed
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[Journal Article] Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia2009
Author(s)
Arai, S., Shibata, H., Sakai, M., Ninomiya, H., Iwata, N., Ozaki, N., Fukumaki, Y.
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Journal Title
Psychiatr. Genet 19
Pages: 6-13
Peer Reviewed
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[Journal Article] Heterozygous deletion of ITPR1, but not SUMF1 in spinocerebellar ataxia type 162008
Author(s)
Iwaki A., Kawano Y., Miura S., Shibata H., Matsuse D., Li W., Furuya H., Ohyagi Y., Taniwaki T., Kira J. and Fukumaki Y.
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Journal Title
J. Med. Genet. 45
Pages: 32-35
Peer Reviewed
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[Journal Article] Reversal of the expression pattern of Aldolase C mRNA in Purkinje cells and Ube 1x mRNA in Golgi cells by a dopamine D1 receptor agonist injections in the methamphetamine sensitized-rat cerebellum2008
Author(s)
Hamamura, M., Hirata, N., Sawada, K., Shuto, T., Shimazoe, T., Terada ,Y., Fukumaki, Y.
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Journal Title
J.Neural Transm. 115
Pages: 959-971
Peer Reviewed
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[Journal Article] Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3 and SLC1A6 with schizophrenia2007
Author(s)
Deng, X., Shibata, H., Takeuchi, N., Rachi, N., Sakai, M., Hideaki Ninomiya, H., Iwata, N., Ozaki, O. and Fukumaki, Y.
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Journal Title
Am. J. Med. Genet. 144B
Pages: 271-278
Peer Reviewed
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[Journal Article] Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia
Author(s)
Shibata, H., Aramaki, T., Sakai, M., Ninomiya, H., Tashiro, N., Iwata, N., Ozaki, O. and Fukumaki,Y.
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Journal Title
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[Presentation] Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A9, SLC6A5 with schizophrenia2007
Author(s)
Deng X, Sagata N, Takeuchi N,Tanaka M, Shibata H, Ninomiya H, Iwata N, Ozaki N, Fukumaki Y.
Organizer
The XVth World Congress of Psychiatric Genetics
Place of Presentation
New York,NY.
Year and Date
20070010-10
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[Presentation] Locus-wide association study of genes in the 5q33.1 region with schizophrenia2006
Author(s)
Fukumaki, Y., Goto, H., Shibata, H., Takaji, M., Ninomiya, N., Tashiro N. and Jarusuraisin, N.
Organizer
The XIVth World Congress of Psychiatric Genetics
Place of Presentation
Cagliari, Italy.
Year and Date
20060010-30
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[Remarks] ゲノムひろば(京都)ポスター展示(2006, 11/18,19)
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[Remarks] ミニゲノムひろば(福岡)ポスター展示 (2006, 12/10)
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[Remarks] 城南高等学校(福岡)教育講演 (2007, 11/24)
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[Remarks] ミニゲノムひろば(福岡)ポスター展示 (2007, 12/23)
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[Remarks] ゲノムひろば(名古屋)ポスター展示 (2008, 10/25,26)
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[Remarks] ミニゲノムひろば(福岡)講演、ポスター展示(2008, 12/21)