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2008 Fiscal Year Final Research Report

Molecular mechanism of Mycoplasma gliding

Research Project

  • PDF
Project/Area Number 18209013
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionOsaka City University

Principal Investigator

MIYATA Makoto  Osaka City University, 大学院・理学研究科, 教授 (50209912)

Project Period (FY) 2006 – 2008
Keywordsマイコプラズマ / 滑走運動 / ATPアーゼ / 結合対象 / シアル酸 / 分子構造 / 数学モデル / 細胞骨格構造
Research Abstract

ヒト肺炎の原因菌などとして知られるマイコプラズマは菌体の片側に膜突起を形成し,固形物表面を滑るように動く,"滑走運動"を行う.本研究計画では,この現象のメカニズムに迫るため,装置とそれをささえる構造,そしてそれらの構成部品を単離し,それらの構造を明らかにした.また,マイコプラズマが滑走時に宿主細胞上のどんな構造をつかんでいるかをつきとめ,メカニズムを説明するモデルの提案を行った.

  • Research Products

    (62 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (27 results) (of which Peer Reviewed: 15 results) Presentation (35 results)

  • [Journal Article] Unique centipede mechanism of Mycoplasma gliding.2010

    • Author(s)
      Miyata M
    • Journal Title

      Annual Review of Microbiology 64(印刷中)

    • Peer Reviewed
  • [Journal Article] Molecular shape and binding force of Mycoplasma mobile's leg protein Gli349 revealed by an AFM study.2010

    • Author(s)
      Lesoil C, Nonaka T, Sekiguchi H, Osada T, Miyata M, Afrin R, Ikai A
    • Journal Title

      Biochemical and Biophysical Research Communications 391

      Pages: 1312-1317

    • Peer Reviewed
  • [Journal Article] Triskelion structure of Gli521 protein involved in gliding mechanism of Mycoplasma mobile.2010

    • Author(s)
      Nonaka T, Adan-Kubo J, Miyata M
    • Journal Title

      Journal of Bacteriology 192

      Pages: 636-642

    • Peer Reviewed
  • [Journal Article] 病原細菌, マイコプラズマのユニークな滑走運動2010

    • Author(s)
      宮田真人
    • Journal Title

      化学と生物 48

      Pages: 176-181

  • [Journal Article] 病原細菌, マイコプラズマのユニークな滑走運動を支える細胞骨格2010

    • Author(s)
      宮田真人中根大介
    • Journal Title

      生物の科学遺伝 2010.3号

      Pages: 47-51

  • [Journal Article] Regions on Gli349 and Gli521 protein molecules directly involved in movements of Mycoplasma mobile gliding machinery suggested by inhibitory antibodies and mutants.2009

    • Author(s)
      Uenoyama A, Seto S, Nakane D,, Miyata M
    • Journal Title

      Journal of Bacteriology 191

      Pages: 1982-1985

    • Peer Reviewed
  • [Journal Article] Cytoskeletal asymmetrical-dumbbell structure of a gliding mycoplasma, Mycoplasma gallisepticum, revealed by negative-staining electron microscopy.2009

    • Author(s)
      Nakane D, Miyata M
    • Journal Title

      Journal of Bacteriology 191

      Pages: 3256-3264

    • Peer Reviewed
  • [Journal Article] マイコプラズマ滑走運動の分子メカニズム2009

    • Author(s)
      宮田真人
    • Journal Title

      IFO RESEARCH COMMUNICATIONS 23

      Pages: 131-138

  • [Journal Article] マイコプラズマのひみつ-モータータンパク質も細胞骨格も使わない細胞運動-2009

    • Author(s)
      宮田真人, 実験室の厄介者
    • Journal Title

      生化学 81

      Pages: 31-34

  • [Journal Article] Mycoplasma pneumoniaeの滑走運動2009

    • Author(s)
      宮田真人中根大介
    • Journal Title

      生体の科学 60

      Pages: 90-102

  • [Journal Article] うごめくバイ菌, マイコプラズマのユニークな運動メカニズム2008

    • Author(s)
      宮田真人
    • Journal Title

      現代化学 5

      Pages: 27-32

  • [Journal Article] Centipede and inchworm models to explain Mycoplasma gliding2007

    • Author(s)
      Miyata M
    • Journal Title

      Trends in Microbiology 16

      Pages: 6-12

    • Peer Reviewed
  • [Journal Article] Molecular mechanism of Mycoplasma gliding-a novel cell motility system2007

    • Author(s)
      Miyata M
    • Journal Title

      Cell Motility (Lenz, P., ed). Springer

      Pages: 137-175

    • Peer Reviewed
  • [Journal Article] Cytoskeletal "Jellyfish" structure of Mycoplasma mobile2007

    • Author(s)
      Nakane D, Miyata M
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America 104

      Pages: 19518-19523

    • Peer Reviewed
  • [Journal Article] マイコプラズマ滑走運動の分子メカニズム-ユニークな生体運動-2007

    • Author(s)
      宮田真人
    • Journal Title

      日本細菌学会雑誌 62

      Pages: 347-661

  • [Journal Article] 表面を・つかんではなす・マイコプラズマ2007

    • Author(s)
      宮田真人
    • Journal Title

      表面科学 28

      Pages: 198-203

  • [Journal Article] Identification of a novel nucleoside triphosphatase from Mycoplasma mobile: a prime candidate for motor of gliding motility2007

    • Author(s)
      Ohtani N, Miyata M
    • Journal Title

      Biochmical Journal 403

      Pages: 71-77

    • Peer Reviewed
  • [Journal Article] Cytoskeleton of mollicutes.2006

    • Author(s)
      Miyata M, Ogaki H
    • Journal Title

      Journal of Molecular Microbiology and Biotechnology 11

      Pages: 256-264

    • Peer Reviewed
  • [Journal Article] A microrotary motor powered by bacteria.2006

    • Author(s)
      Hiratsuka Y, Miyata M, Tada T,, Uyeda TQ
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America 103

      Pages: 13618-13623

    • Peer Reviewed
  • [Journal Article] Morphology of isolated Gli349, a leg protein responsible for glass binding of Mycoplasma mobile gliding revealed by rotary-shadowing electron microscopy.2006

    • Author(s)
      Adan-Kubo J, Uenoyama A, Arata T, Miyata M
    • Journal Title

      Journal of Bacteriology 188

      Pages: 2821-2828

    • Peer Reviewed
  • [Journal Article] 患者といっしょに歩き回るマイコプラズマ2006

    • Author(s)
      宮田真人
    • Journal Title

      化学療法の領域 23

      Pages: 267-272

  • [Journal Article] "walking pneumonia"の病原菌であるマイコプラズマは患者と同様に歩きまわる2006

    • Author(s)
      宮田真人
    • Journal Title

      感染・炎症・免疫 36

      Pages: 72-73

  • [Journal Article] 電顕に期待するもの(1)2006

    • Author(s)
      宮田真人
    • Journal Title

      細胞工学 25

      Pages: 1186-1187

  • [Journal Article] マイコプラズマの滑走運動-ここまでわかった未知の構造と生体運動メカニズム2006

    • Author(s)
      宮田真人
    • Journal Title

      顕微鏡 41

      Pages: 39-44

  • [Journal Article] マイコプラズマの細胞運動メカニズムATPで滑走するバクテリア2006

    • Author(s)
      宮田真人
    • Journal Title

      BioNics 3

      Pages: 52-58

    • Peer Reviewed
  • [Journal Article] Motor-substrate interactions in Mycoplasma. Motility explains non-Arrhenius temperature dependence.

    • Author(s)
      Chen J, Neu J, Miyata M, Oster G
    • Journal Title

      Biophysical Journal 97

      Pages: 2930-2938

    • Peer Reviewed
  • [Journal Article] Gliding motility of Mycoplasma mobile can occur by repeated binding to N-acetylneuraminyllactose (sialyllactose) fixed on solid surfaces.

    • Author(s)
      Nagai R, Miyata M
    • Journal Title

      Journal of Bacteriology 188

      Pages: 6469-6475

    • Peer Reviewed
  • [Presentation] Gliding motility of human pathogen, Mycoplasma pneumoniae2010

    • Author(s)
      宮田真人
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-03-29
  • [Presentation] 最小生物, マイコプラズマのユニークな滑走運動2010

    • Author(s)
      宮田真人
    • Organizer
      日本物理学会第65回年次大会
    • Place of Presentation
      岡山市
    • Year and Date
      2010-03-21
  • [Presentation] マイコプラズマのステップ2010

    • Author(s)
      中根大介, 西坂崇之, 宮田真人
    • Organizer
      2010年生体運動研究合同班会議
    • Place of Presentation
      東京都
    • Year and Date
      2010-01-11
  • [Presentation] マイコプラズマ'の全くユニークな滑走運動メカニズム2009

    • Author(s)
      宮田真人, 病原細菌
    • Organizer
      第55回生命機能研究科研究交流会
    • Place of Presentation
      吹田市
    • Year and Date
      2009-12-18
  • [Presentation] Mycoplasma gliding-a novel mechanism of bacterial surface motility-2009

    • Author(s)
      宮田真人
    • Organizer
      第4回人工筋肉コンファレンス-生体模倣, 人工筋肉とナノバイオに関する第5回国際会議
    • Place of Presentation
      豊中市
    • Year and Date
      2009-11-26
  • [Presentation] The Cytoskeletal structure of Mycoplasma gliding2009

    • Author(s)
      Miyata M
    • Organizer
      108th General Meeting of American Society for Microbiology
    • Place of Presentation
      Boston
    • Year and Date
      2009-06-04
  • [Presentation] Cytoskeletal structure of a gliding Mycoplasma, Mycoplasma gallisepticum, revealed by negative-staining electron microscopy and image averaging2009

    • Author(s)
      Nakane D, Miyata M
    • Organizer
      108th General Meeting of American Society for Microbiology
    • Place of Presentation
      Boston
    • Year and Date
      2009-06-02
  • [Presentation] 病原細菌, マイコプラズマの滑走運動-構造とメカニズム-2009

    • Author(s)
      宮田真人
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-03-29
  • [Presentation] マイコプラズマ滑走運動の分子メカニズム2009

    • Author(s)
      宮田真人
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-03-12
  • [Presentation] Tethered Mycoplasma2009

    • Author(s)
      Nakane D, Miyata M
    • Organizer
      BLAST X
    • Place of Presentation
      Cuernavaca
    • Year and Date
      2009-01-20
  • [Presentation] Molecular shapes of Gli123 and Gli521 involved in gliding motility of Mycoplasma mobile2009

    • Author(s)
      Nonaka T, Adan-Kubo J, Miyata M
    • Organizer
      BLAST X
    • Place of Presentation
      Cuernavaca
    • Year and Date
      2009-01-19
  • [Presentation] 病原細菌, マイコプラズマの滑走運動-構造とメカニズム-2008

    • Author(s)
      宮田真人
    • Organizer
      認定NPO法人第5回可視技術ワークショップ「バイオイメージングテクノロジーを用いた微生物多様性へのアプローチ」
    • Place of Presentation
      東京都
    • Year and Date
      2008-11-08
  • [Presentation] High-resolution quick imaging of Cytoskeletal architecture of Mycoplasma pneumoniae and Mycoplasma gallisepticum using conventional electron Microscopy2008

    • Author(s)
      Nakane D, Kenri T, Miyata M
    • Organizer
      17th IOM Congress
    • Place of Presentation
      Tianjin
    • Year and Date
      2008-07-11
  • [Presentation] Surviving strategies of Mycoplasma mobile by antigenic of Mvsp12008

    • Author(s)
      H.N. Wu, Miyata M
    • Organizer
      17th IOM Congress
    • Place of Presentation
      Tianjin
    • Year and Date
      2008-07-11
  • [Presentation] Molecular shapes of Gli521 and Gli123 involved in gliding motility of Mycoplasma mobile2008

    • Author(s)
      Nonaka T, Adan-Kubo J, Miyata M
    • Organizer
      17th IOM Congress
    • Place of Presentation
      Tianjin
    • Year and Date
      2008-07-11
  • [Presentation] Jellyfish structure of Mycoplasma mobile2008

    • Author(s)
      Nakane D, Miyata M
    • Organizer
      17th IOM Congress
    • Place of Presentation
      Tianjin
    • Year and Date
      2008-07-11
  • [Presentation] マイコプラズマ滑走装置とそれを支える構造2008

    • Author(s)
      宮田真人
    • Organizer
      日本顕微鏡学会第64回学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2008-05-21
  • [Presentation] マイコプラズマ滑走運動のメカニズム2008

    • Author(s)
      宮田真人
    • Organizer
      第17回北里研究所学会賞受賞者特別講演会
    • Place of Presentation
      東京都
    • Year and Date
      2008-01-29
  • [Presentation] Mycoplasma gliding; a novel mechanism of biomotility2007

    • Author(s)
      Miyata M
    • Organizer
      第30回日本分子生物学会年会第60回日本生化学会大会合同大会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-12-11
  • [Presentation] マイコプラズマ滑走運動2007

    • Author(s)
      宮田真人
    • Organizer
      第45回日本放線菌学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2007-10-05
  • [Presentation] Mycoplasma gliding-a novel mechanism of biological surface motility2007

    • Author(s)
      Miyata M
    • Organizer
      The International Conference on Science of Friction
    • Place of Presentation
      Irago
    • Year and Date
      2007-09-10
  • [Presentation] Mycoplasma glide with a novel mechanism2007

    • Author(s)
      Miyata M
    • Organizer
      The 7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji
    • Year and Date
      2007-08-27
  • [Presentation] Mycoplasma gliding-a novel mechanism of cell motility2007

    • Author(s)
      Miyata M
    • Organizer
      第40回日本発生生物学会第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡市
    • Year and Date
      2007-05-30
  • [Presentation] マイコプラズマの滑走運動-全く新しい生体運動メカニズム2007

    • Author(s)
      宮田真人
    • Organizer
      第44回レプトスピラシンポジウム
    • Place of Presentation
      大阪市
    • Year and Date
      2007-03-25
  • [Presentation] Isolation and characterization of P1 adhesin, leg protein of gliding motility of Mycoplasma pneumoniae2007

    • Author(s)
      Nakane D, Adan-Kubo J, Kenri T, Miyata M
    • Organizer
      BLAST IX
    • Place of Presentation
      Lauphlin
    • Year and Date
      2007-01-16
  • [Presentation] Jellyfish structure of gliding bacterium, Mycoplasma mobile2007

    • Author(s)
      Nakane D, Miyata M
    • Organizer
      BLAST IX
    • Place of Presentation
      Lauphlin
    • Year and Date
      2007-01-15
  • [Presentation] マイコプラズマの細胞骨格はくらげ構造か?2007

    • Author(s)
      中根大介, 宮田真人
    • Organizer
      2007年生体運動研究合同班会議
    • Place of Presentation
      金沢市
    • Year and Date
      2007-01-09
  • [Presentation] マイコプラズマの滑走運動-あらたな生体運動のメカニズム-2006

    • Author(s)
      宮田真人
    • Organizer
      第21回生体機能関連化学シンポジウム「若手フォーラム」
    • Place of Presentation
      京都市
    • Year and Date
      2006-09-27
  • [Presentation] Mapping of localization sites of cytadherence-rated and cytosketal proteins of Mycoplasma pneumoniae by fluorescent protein tapping2006

    • Author(s)
      Kenri T, Seto S, Horino A, Arakawa Y, Sasaki T, Miyata M
    • Organizer
      16th IOM Congress
    • Place of Presentation
      Cambridge
    • Year and Date
      2006-07-14
  • [Presentation] Morphology of isolated Mvsp1, a putative antigenic variation protein of Mycoplasma mobile2006

    • Author(s)
      Adan-Kubo J, Miyata M
    • Organizer
      16th IOM Congress
    • Place of Presentation
      Cambridge
    • Year and Date
      2006-07-14
  • [Presentation] Isolation and characterization of P1 adhesin involved in gliding motility of Mycoplasma pneumoniae2006

    • Author(s)
      Nakane D, Adan-Kubo J, Kenri T, Miyata M
    • Organizer
      16th IOM Congress
    • Place of Presentation
      Cambridge
    • Year and Date
      2006-07-13
  • [Presentation] Gliding ghost of Mycoplasma mobile2006

    • Author(s)
      Uenoyama A, Miyata M
    • Organizer
      16th IOM Congress
    • Place of Presentation
      Cambridge
    • Year and Date
      2006-07-13
  • [Presentation] Molecular mechanism of Mycoplasma gliding2006

    • Author(s)
      Miyata M, Uenoyama A, Adan-Kubo J, Nagai R, Ohtani N
    • Organizer
      16th IOM Congress
    • Place of Presentation
      Cambridge
    • Year and Date
      2006-07-10
  • [Presentation] 表面タンパク質の形態から考える滑走運動メカニズムとその進化的由来2006

    • Author(s)
      宮田真人
    • Organizer
      第33回日本マイコプラズマ学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2006-06-02
  • [Presentation] あたらしい生体運動メカニズム-マイコプラズマの滑走運動-2006

    • Author(s)
      宮田真人
    • Organizer
      第54回日本化学療法学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2006-05-19

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Published: 2011-06-18   Modified: 2016-04-21  

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