2008 Fiscal Year Final Research Report
Development and diagnosis/therapy application of magnetic beads exhibiting surface/uptake affinity to cancer cells
| Project/Area Number |
18209019
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
ABE Masanori Tokyo Institute of Technology, 大学院・理工学研究科, 教授 (70016624)
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| Co-Investigator(Kenkyū-buntansha) |
HANDA Hiroshi 東京工業大学, 大学院・生命理工学研究科, 教授 (80107432)
KOUDA Eiichi 東邦大学, 医学部, 教授 (80101989)
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| Project Period (FY) |
2006 – 2008
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| Keywords | 医用磁性ビーズ / ハイパーサーミア / MR造影 / ナノカプセル |
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| Research Abstract |
病原性のないウイルスの外殻を作っているたんぱく質に由来する分子を自己組織化させて"ナノカプセル" を合成する反応中にその内部にフェライト粒子を内包させた。このナノカプセル・フェライトビーズは、がん細胞の表面に特異的に吸着あるいは内部に取り込まれる性質があることが示唆されたので、これによって抗がんハイパーサーミア用の発熱体およびMR 造影剤としての効率を高めることができると期待される。
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Research Products
(15 results)
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[Journal Article] SV40 vectors carrying minimal sequence of viral origin with exchangeable capsids2008
Author(s)
NAKANISHI, A., Chapellie, B., Maekawa, N., Hiramoto, M., Kuge, T., Takahashi, R-H., Handa, H., and Imai, T
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Journal Title
Virology 379
Pages: 110-117
Peer Reviewed
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[Journal Article] Presentation of functional foreign peptides on the surface of SV40 virus like particles2008
Author(s)
Takahashi, R-H., Kanesashi, S-N., Inoue, T., Enomoto, T., Kawano, M-A., Tsukamoto, H., Takeshita, F., Imai, T., Ochiya, T., Kataoka, K., Yamaguchi, Y. and Handa, H.
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Journal Title
J. Biotechnol 135
Pages: 385-392
Peer Reviewed
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[Journal Article] Identification of a chemical substructure that is immobilized to ferrite nanoparticles (FP)2007
Author(s)
Kosuke Nishio, Nobuyuki Gokon, Makoto Hasegawa, Yuji Ogura, Morihito Ikeda, Hiroki Narimatsu, Masaru Tada, Yuki Yamaguchi, Satoshi Sakamoto, Masanori Abe and Hiroshi Handa
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Journal Title
Colloids and Surfaces B : Biointerfaces 54, 2
Pages: 249-253
Peer Reviewed
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[Journal Article] The VP2/VP3 minor capsid ptotein of SV40 promotes the in vitro assembly of the major capsid protein VP1 into particles2006
Author(s)
Kawano, M., Inoue, T., Tsukamoto, H., Takaya, T., Enomoto, T., Takahashi, R. U., Yokoyama, N., Yamamoto, N., Nakanishi, A., Imai, T., Wada, T., Kataoka, K. and Handa, H
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Journal Title
J. Biol. Chem 281
Pages: 10164-10173
Peer Reviewed
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[Presentation] Heating ability of iron oxide nanoparticles at 120-900 kHz for magnetic anticancer hyperthermia2007
Author(s)
K. Okawa, T. Kanemaru, M. Tada, T. Nakagawa, Y. Hase, S. Nomura, M. Ikeda, K. Nishio, H. Handa, M. Abe
Organizer
The 1st International Symposium on Advanced Magnetic Materials (ISAMMA2007)
Place of Presentation
Jeju, Korea (invited)
Year and Date
20070328-0601
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[Book]2008
Author(s)
Hiroshi Handa, Masaaki Kawano, R. Holland Cheng
Total Pages
644
Publisher
World scientific, STRUCTURE BASED STUDY OF VIRAL REPLICATION
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