2009 Fiscal Year Final Research Report
Detection of a Novel Biomarker to Monitor Antiplatelet Therapy
| Project/Area Number |
18209021
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Keio University |
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Principal Investigator |
MURATA Mitsuru Keio University, 医学部, 教授 (50174305)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 抗血小板薬 / 血小板機能 / モニタリング / 臨床検査 / 血栓症 / 遺伝子ターゲティング / トランスクリプトーム解析 / プロテオーム解析 |
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| Research Abstract |
Although there are wide inter-individual variations in platelet sensitivity to antiplatelet drugs, antiplatelet therapy is currently not monitored with laboratory tests. In this study, to identify biomarker(s) of the effects of antiplatelet drugs, we performed comprehensive studies and candidate approaches on blood samples from patients receiving antiplatelet therapy. Both the comprehensive studies and candidate approaches showed that plasma levels of glycocalicin, known as fragments of extracellulardomain of a platelet receptor glycoprotein Ib alpha, were associated with platelet response to aspirin. This study also developed a facile protocol for quantitative analysis of glycocalicin.
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[Journal Article] Association of Asn221Ser mutation in tissue factor pathway inhibitor-βwith plasma total tissue factor pathway inhibitor level.2009
Author(s)
Ishikawa J, Okada H, Kato H, Takeshita S, Honda S, Kawasaki T, Suehisa E, Tsuji H, Madoiwa S, Sakata Y, Kojima T, Murata M, Ikeda Y, Kokubo Y, Okamura T, Tomoike H, Miyata T
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Journal Title
Blood coagulation and Fibrinolysis Vol20No1
Pages: 22-26
Peer Reviewed
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[Journal Article] Pregnancy-induced thrombocytopenia and TTP, and the risk of foetal death, in Upshaw-Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients.2009
Author(s)
Fujimura Y, Matsumoto M, Kokame K, Isonishi A, Soejima K, Akiyama N, Tomiyama J, Natori K, Kuranishi Y, Imamura Y, Inoue N, Higasa S, Seike M, Kozuka T, Hara M, Wada H, Murata M, Ikeda Y, Miyata T, George JN
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Journal Title
British Journal of Haematology 144(5)
Pages: 742-754
Peer Reviewed
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