2008 Fiscal Year Final Research Report
Development of the personalized prevention system for ischemic stroke by a genome-wide association study
| Project/Area Number |
18209023
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Mie University |
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Principal Investigator |
YAMADA Yoshiji Mie University, 生命科学研究支援センター, 教授 (90333286)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIHARA Sahoko 三重大学, 生命科学研究支援センター, 助教 (20378326)
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Toshio 独立行政法人理化学研究所, 基盤研究所, チームリーダ
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| Project Period (FY) |
2006 – 2008
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| Keywords | ゲノム / 関連解析 / オーダーメイド予防 / 脳血管障害 / アテローム血栓性脳梗塞 / 脳血栓 / 脳出血 / くも膜下出血 |
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| Research Abstract |
候補遺伝子アプローチによる300遺伝子多型の関連解析を行い、IL6遺伝子-572G→C、ABCA1遺伝子-14C→T、IRAK1遺伝子A→C、C→T(Ser532Leu)、ROS1遺伝子G→C(Cys2229Ser)が脳血栓の発症に、IL6遺伝子-572G→C、LIMK1遺伝子-428G→Aが脳出血の発症に、UCP3遺伝子-55C→T、TNF遺伝子-863C→A、KIAA0319L遺伝子G→A(Gly243Asp)、CYP3A4遺伝子13989A→G(Ile118Val)がくも膜下出血の発症にそれぞれ関連することを見出した。次に、3つの独立した集団で合計6341例(脳血栓992例および対照5349例)についてゲノム全領域関連解析を行い、脳血栓発症と強く関連するCELSR1遺伝子と2個のSNPs、A→G(Thr2268Ala, rs6007897)およびA→G(Ile2107Val, rs4044210)を同定した。
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[Journal Article] Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals2008
Author(s)
Yoshiji Yamada, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Kimihiko Kato, Takeshi Hibino, Kiyoshi Yokoi, Sachiro Watanabe, Sahoko Ichihara, Yukitoshi Aoyagi, Akitomo Yasunaga, Hyuntae Park, Masashi Tanaka, Yoshinori Nozawa
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Journal Title
Stroke 39
Pages: 2211-2218
Peer Reviewed
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[Journal Article] Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in Japanese individuals2008
Author(s)
Yoshiji Yamada, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Kiyoshi Yokoi, Hitoshi Matsuo, Sachiro Watanabe, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Sahoko Ichihara, Yukitoshi Aoyagi, Akitomo Yasunaga, Hyuntae Park, Masashi Tanaka, Yoshinori Nozawa
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Journal Title
J Med Genet 45
Pages: 216-221
Peer Reviewed
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[Journal Article] Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians2007
Author(s)
Noriyuki Fuku, Kyong Soo Park, Yoshiji Yamada, Yutaka Nishigaki, Young Min Cho, Hitoshi Matsuo, Tomonori Segawa, Sachiro Watanabe, Kimihiko Kato, Kiyoshi Yokoi, Yoshinori Nozawa, Hong Kyu Lee, Masashi Tanaka
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Journal Title
Am J Hum Genet 80
Pages: 407-415
Peer Reviewed
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[Journal Article] Genetic risk for ischemic and hemorrhagic stroke2006
Author(s)
Yoshiji Yamada, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Sahoko Ichihara, Kimihiko Kato, Takashi Kameyama, Kiyoshi Yokoi, Hitoshi Matsuo, Tomonori Segawa, Sachiro Watanabe, Yoshinori Nozawa
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Journal Title
Arterioscler Thromb Vasc Biol 26
Pages: 1920-1925
Peer Reviewed
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[Journal Article] Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study
Author(s)
Yoshiji Yamada, Noriyuki Fuku, Masashi Tanaka, Yukitoshi Aoyagi, Motoji Sawabe, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Kimihiko Kato, Sachiro Watanabe, Yoshinori Nozawa, Aki Hasegawa, Toshio Kojima
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Journal Title
Atherosclerosis (in press)
Peer Reviewed
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